Abstract
Catecholamine concentrations were determined in newborn rats treated with large doses of sodium fluoride (10 mg/kg) for varying periods of time. When fluoride treatment was started on day 5 after birth and continued daily to day 35 of life, decreased catecholamine concentrations were observed in the heart, kidney and liver. Daily fluoride treatment from day 15 through day 35 after birth failed to influence cardiac, kidney or liver catecholamines. Neither treatment regimen affected adrenal epinephrine or norepinephrine levels. These experiments suggest that fluoride may be affecting catecholamine biosynthetic mechanisms which are developing during days 5–10 of life.
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NOTE:
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•• Supported in part by Grant No. GM 15190 from the National Institutes of Health.
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•• Author’s Present address: Woo Suk University Medical School, Seoul, Changraku, Myun Ryun Dong, Seoul, Korea.
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The effects of fluoridated water on rat urine and tissue cAMP levels
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The physiologic and hygienic aspects of the absorption of inorganic fluorides
Physiologic and hygienic aspects of the absorption of inorganic fluorides are reviewed. Three basic shortcomings in fluoride research are noted: its intake into the system, assimilation, and excretion are subject to great variation between persons; in contrast to extensive biochemical advances in fluoride research, relatively little clinical data is available
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Effects of melatonin and epiphyseal proteins on fluoride-induced adverse changes in antioxidant status of heart, liver, and kidney of rats
Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart,
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Evaluation of serum lipoprotein and tissue antioxidant levels in sheep with fluorosis
The aim of this study was to evaluate serum lipoprotein and tissue antioxidant levels of sheep with and without fluorosis living in a volcanic area of Turkey. Fifteen Akkaraman sheep with fluorosis in the A?ri region north of Lake Van and 10 Akkaraman sheep without fluorosis in the Van region
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