Abstract
Catecholamine concentrations were determined in newborn rats treated with large doses of sodium fluoride (10 mg/kg) for varying periods of time. When fluoride treatment was started on day 5 after birth and continued daily to day 35 of life, decreased catecholamine concentrations were observed in the heart, kidney and liver. Daily fluoride treatment from day 15 through day 35 after birth failed to influence cardiac, kidney or liver catecholamines. Neither treatment regimen affected adrenal epinephrine or norepinephrine levels. These experiments suggest that fluoride may be affecting catecholamine biosynthetic mechanisms which are developing during days 5–10 of life.
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NOTE:
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•• Supported in part by Grant No. GM 15190 from the National Institutes of Health.
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•• Author’s Present address: Woo Suk University Medical School, Seoul, Changraku, Myun Ryun Dong, Seoul, Korea.
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Effect of chronic exposure to sodium fluoride and 7,12- dimethylbenz[a]anthracene on some blood parameters and hepatic, renal, and cardiac histopathology in rats.
This study aimed to investigate the effects of both sodium fluoride (NaF) and 7,12-dimethylbenz[a]anthracene (DMBA), both separately and in combination, on some blood parameters and hepatic, renal, and cardiac histopathology in rats. Forty male Wistar albino rats, weighing 250–300 g, were randomly divided into one control and three experimental groups
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The clinical features of 160 cases of acute sodium silicon fluoride poisoning.
160 cases of acute sodium silicon fluoride poisoning due to accidental intake are reported in this paper. Owing to the great amount of the chemical taken, the onset was abrupt and the digestive symptoms were prominent and severe. Twelve cases had acute gastritis or acute ulceration as shown by gastroscopy.
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Influence of supplementary vitamins and minerals on lipid peroxidation and redox state in heart, kidney and liver of rats exposed to fluoride.
The effect of fluoride (F) and supplementary vitamins and minerals on lipid peroxidation (LPO) and redox state (RS) in heart , kidney and liver of 40 (4 groups of 10) male Wistar rats were studied. One group of rats was left untreated as control, group 1 was received 5 mg/l
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A fatality due to ingestion of hydrofluoric acid.
We report a fatal case of hydrofluoric acid (HF) ingestion with suicidal intent. Quantitation using an ion-selective electrode for fluoride in fresh bile, gastric contents, kidney, liver, skeletal muscle, urine, and vitreous humor yielded 6.5, 39.0, 10.0, 6.0, 4.5, 5.0, and 4.5 ppm, respectively. In addition to the unfixed specimens,
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Effects of melatonin and epiphyseal proteins on fluoride-induced adverse changes in antioxidant status of heart, liver, and kidney of rats
Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart,
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