Abstract
HF exposure might produce adverse effects in industrial workers. A 3 mo. exposure of rats to HF at 10 mg/m3 8 h/day 5 days/wk resulted in increased blood serum concentrations of hydroxyproline and hydroxylysine and in enhanced urinary excretion of these amino acids and in changes of collagen fractions in the liver, lungs and skin. In all tissues studied (especially liver), soluble and insoluble collagen decreased. HF affected biosynthesis and maturation of collagen fibers.
-
-
The effects of the inhalation of hydrogen fluoride. II. The response following exposure to low concentration.
The effects of the inhalation of hydrogen-fluoride (7664-39-3) (HF) on several animals was investigated. Five rabbits, three guinea-pigs and two Rhesus-monkeys were exposed to atmospheric HF at a concentration of 0.0152 milligrams per liter for 6 hours a day. This was repeated for 30 days until a total of 309
-
Effect of chronic exposure to sodium fluoride and 7,12- dimethylbenz[a]anthracene on some blood parameters and hepatic, renal, and cardiac histopathology in rats.
This study aimed to investigate the effects of both sodium fluoride (NaF) and 7,12-dimethylbenz[a]anthracene (DMBA), both separately and in combination, on some blood parameters and hepatic, renal, and cardiac histopathology in rats. Forty male Wistar albino rats, weighing 250–300 g, were randomly divided into one control and three experimental groups
-
Effect of Fluoride on the Expression of 8-Hydroxy-2'-Deoxyguanosine in the Blood, Kidney, Liver, and Brain of Rats.
Excessive exposure of fluoride not only leads to damage on bone, but also has an adverse effect on soft tissues. Oxidative DNA damage induced by fluoride is thought to be one of the toxic mechanisms of fluoride effect. However, the dose–response of fluoride on oxidative DNA damage is barely studied
-
Influence of extended exposure to sodium fluoride and caffeine on the activity of carbohydrate metabolism enzymes in rat blood serum and liver.
A 50-day study of the influence of fluoride (F) and caffeine on carbohydrate metabolism enzymes was conducted on 18 male Sprague-Dawley rats, 4.5 months old, housed in separate cages at 22–25°C on a 12-hr light/dark cycle. The rats were divided into three groups with six rats in each group: control,
-
Protective effect of resveratrol on sodium fluoride-induced oxidative stress, hepatotoxicity and neurotoxicity in rats
Protective effect of resveratrol on sodium fluoride-induced oxidative stress, hepatotoxicity and neurotoxicity were studied in rats. A total of 28 Wistar albino male rats were used. Four study groups were randomly formed with seven animals in each. The groups were treated for 21 days with distilled water (control group), with
Related Studies :
-