Excerpt:
Methods: Male rats received sodium fluoride in their drinking water (1 ppm – tap water; 50 ppm; 100 ppm) for 30 days. After this period, different groups of animals were tested in openfield habituation (two 5-min sessions 24 h apart) and in the twoway active avoidance (two sessions of 30 trials with 10-s of tone – conditioned stimulus – and 5-s of 0.3mA shock delivery – unconditioned stimulus – at final 5 s of CS). Food and water intake, body weight gain and dental fluorosis were also recorded…
Discussion: Thirty days of sodium fluoride administration to rats induced impairment in habituation and two-way active avoidance. Possible mechanisms of these impairments can be the reduction of some subunits of nicotinic receptors and altered hippocampal calcium current found after chronic NaF treatment (Long et al., 2002). In conclusion, the present study reinforces the clinical impression that sodium fluoride has a potential memory impairment effect, which deserves further studies.
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Effect of different doses of chronic exposure of fluoride on rat learning and memory behavior
Objective: Explore the effect of different doses of chronic exposure of fluoride on rat learning and memory behavior. Method: Selected 46 Wistar rats, randomly divided them into a control group, low-fluoride group, and high-fluoride group, had them respectively drink tap water (control group), 100 mg/L (low-fluoride group), and 200 mg/L
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Fluoride Developmental Neurotoxicity- Overview of Evidence and Evaluation of Risk at Exposures Due to Artificial Fluoridation.
The topic of fluoride developmental neurotoxicity has received great attention recently due to the publication of several high-profile studies and because of the questions these raise about the safety of water fluoridation, a long-established public health measure to reduce tooth decay. The recent studies have found associations between fluoride exposures
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The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats
Objective: Explore the effect and possible mechanisms of fluorine exposure of pregnant rats passing through placental barriers on the learning and memory capabilities of baby rats. Method: Open field behavior and a water maze test were used to observe the effects on the spontaneous behavior and learning and memory on baby
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Fluoride exposure and cognitive neurodevelopment: Systematic review and dose-response meta-analysis.
Many uncertainties still surround the possible harmful effect of fluoride exposure on cognitive neurodevelopment in children. The aim of this systematic review and meta-analysis was to characterize this relation through a dose-response approach, by comparing the intelligence quotient (IQ) scores in the highest versus the lowest fluoride exposure category with
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Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content
Objective: Explore the brain mechanism of the effect of fluorosis on learning and memory behavior. Method: A method combining behavioral observation and biochemical testing was used to study the effects of long-term drinking different concentrations of sodium fluoride on mouse learning and memory behavior and changes in content of brain
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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