Abstract
OBJECTIVE: To investigate the pathogenesis of brain damage by fluoride intoxication, phospholipid content, and fatty acid composition in rat brain with fluorosis were annlysed.
METHODS: Wistar rats were fed with NaF in various amounts and time periods to produce the animal model with chronic fluorosis. Phospholipid content and fatty acids composition were analysed using high performance liquid chromatography and gas chromatography, respectively.
RESULTS: All animals fed with high amount of fluoride suffered from chronic fluorosis. The total brain phospholipid content was lower in the rat treated with fluoride, which mainly influenced phosphatidylethanolamine, phosphatidylcholin, and phosphatidylserine. No modifications were detected in fatty acid and aldehyde compositions of individual phospholipid classes.
CONCLUSION: The metabolism of brain phospholipid might be interfered by fluoride accumulated in brain tissue, which is related with the degeneration of neuron. The changes of brain phospholipid could be involved in the pathogenesis of chronic fluorosis.
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Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain
In order to investigate the molecular mechanism(s) underlying brain dysfunction caused by chronic fluorosis, neuronal nicotinic acetylcholine receptors (nAChRs) in the brain of rats receiving either 30 or 100 ppm fluoride in their drinking water for 7 months were analyzed in the present study employing ligand binding and Western blotting.
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Learning and memory obstacles and changes in brain tissue growth inhibitors from brick tea fluoride and aluminum poisoning of rats
Objective: Explore the active mechanisms of growth inhibitors (somatostatin, SS) participating in learning and memory obstacles from brick tea fluoride and aluminum poisoning of rats. Method: Based on the tea-drinking habits of herders, a rat chronic brick tea fluoride and aluminum poisoning animal model was established, and randomly divided into
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Effects of fluoride on anxiety and depression in mice
The aim of this study was to evaluate the effects of fluoride on anxiety and depression in mice. Control and study groups were formed with ten 4-month-old male Swiss mice in each group. For 90 days, mice in the control group were given drinking water containing 0.3 ppm fluoride while the study group
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Beneficial effects of Emblica officinalis on fluoride-induced toxicity on brain biochemical indexes and learning-memory in rats
AIMS: The present study was aimed to investigate the effects of Emblica officinalis against fluoride-induced alterations in the behavioral and biochemical abnormalities in rats. DESIGN: The healthy adult albino rats of Wistar strain (Rattus norvegicus) weighed 200-250 g were used for experiments. The animals were divided into three groups. Group I,
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Pathological changes in the tissues of rats (albino) and monkeys (macaca radiata) in fluorine toxicosis
1. Stomach, duodenum, small intestine, kidney, liver, spleen, skin, heart, aorta, lungs, brain, pancreas, adrenals, thyroid and parathyroid of rats and monkeys suffering from chronic fluorosis have been histologically examined. 2. Fluorine has not been found to have any effect on the heart muscle, aorta, skin and parathyroids, whereas it has
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