To investigate the effect of coal-burning endemic fluorosis on children’s physical development and intellectual level so as to provide data support for the protection of children’s healthy growth in fluorosis areas.
Ninety children with coal-burning endemic fluorosis were selected for the study, which were divided into heavy fluorosis area group, middle fluorosis area group and light disease area group. 30 children in each group. Another 30 children were selected from non-fluorosis areas as normal group. The index of physical development and intellectual level of each group were compared.
Dental fluorosis and urinary fluoride concentration of fluorosis area groups were higher than that of normal group (P<0.05); index of height, weight and vital capacity in normal group children’s was significantly better than that of other 3 groups (P<0.050); intelligence quotient (IQ) index in fluorosis groups was lower than that of normal group (P<0.05).
The coal-burning endemic fluorosis may have a serious impact on children’s physical growth and intellectual level, active preventive measures should be attached to protect children’s health.
Fluoride exposure, dopamine relative gene polymorphism and intelligence: A cross-sectional study in China.
Highlights Urine fluoride was inversely associated with IQ. IQ of children with high-activity MAOA genotype was lower than IQ of those with low-activity or female heterozygote genotype. DAT1 and MAOA gene polymorphism modify the effects of UF on IQ. UF, ANKK1, COMT and MAOA have a high-dimensional interaction on
Investigation on children’s growth and development under long-term fluoride exposure
Objective To study the influence on children’s growth by long-term high fluoride exposure. Methods Case group was selected in high fluoride areas and control group was selected in non-high fluoride areas. The difference of children’s growth levels were analyzed between 2 groups. Results The IQ of case group was significantly lower than that of control
The relationships between thyroid-stimulating hormone and/or dopamine levels in peripheral blood and IQ in children with different urinary iodine concentrations.
Highlights TSH is not related IQ in children with different urinary iodine concentrations. Dopamine in plasma is unrelated to IQ in children with adequate or excessive iodine. Dopamine has positive correlation with intelligence in iodine deficiency group. The interaction between dopamine in plasma and TSH is not related to
Pharmacological implications of ipriflavone against environmental metal-induced neurodegeneration and dementia in rats.
Long-term exposure to environmental neurotoxic metals is implicated in the induction of dementia and cognitive decline. The present study aims to illustrate the therapeutic role of ipriflavone as a synthetic isoflavone against environmental metal–induced cognitive impairment in rats. Dementia was induced by a mixture of aluminum, cadmium, and fluoride for 90
The effects of high levels of fluoride and iodine on intellectual ability and the metabolism of fluoride and iodine.
The authors carried out a study on the intellectual abilities and fluoride/iodine metabolism of children living in a high fluoride-high iodine area. Among the results: the percentage of the general population living in this fluoride/iodine-contaminated region that suffered from goiter (clinical thyroid enlargement) was 3.8%, the rate of children already showing some thyroid
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Fluoride Affects Learning & Memory in Animals
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Fluoride & IQ: 69 Studies
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
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Fluoride's Direct Effects on Brain: Animal Studies
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