SUMMARY: Brain tissues for neurohistopathological study were obtained at
autopsy from albino rabbits that had been subcutaneously injected for 15
weeks with 0, 5, 10, 20, and 50 mg of sodium fluoride in 1 mL of aqueous solu-
tions/kg bw/day. Neuropathological changes occurred with loss of the mo-
lecular layer and glial cell layer in the brain tissues of rabbits exposed to the
three higher fluoride doses. The Purkinje neurones exhibited chromatolysis
and acquired a “ballooned” appearance. Nissl substance showed various de-
grees of decrease and even complete loss. Fragmented particles were re-
tained in the perinuclear zone. The perikaryon showed vacuolization, and
spheroid bodies were present in the neuroplasm. These cytoplasmic inclu-
sions appeared as various sized ovoid bodies or elongated eosinophilic
masses due to which the nucleus was shifted to the periphery. These neuro-
toxic changes in the brain suggested that there was a direct action of fluoride
upon the nerve tissue which was responsible for central nervous system
problems such as tremors, seizures, and paralysis indicating brain dysfunc-
tion seen at the two highest doses.
Molecular mechanism of brain impairment caused by drinking-acquired fluorosis and selenium intervention
This study investigated the molecular mechanism of brain impairment induced by drinking fluoridated water and selenium intervention. Results showed that the learning and memory of rats in NaF group significantly decreased. Moreover, the number of apoptotic cells, the expression levels of Cytc mRNA and protein, and the expression levels of
Reduction of CAMKII expression in the hippocampus of rats from ingestion of fluoride and/or lead.
Co-existing as environmental pollutants in certain areas of China where lead (Pb) is mined, fluoride (F) and Pb pose serious risks to the human central nervous system (CNS). Calcium/calmodulin-dependent protein kinase II (CaMKII) expression, which is involved in the process of learning and memory, has an important role in CNS
Toxin-induced blood vessel inclusions caused by the chronic administration of Aluminum and Sodium fluoride and their implications for dementia
Until our knowledge of the etiology of Alzheimer's dementia, as well as related conditions involving mental impairments, is greatly extended, no line of investigation should be ignored. We believed that the possible contributions of aluminum exposure to neural impairments deserved further study. In coming to this opinion we were mindful
Effect of sodium fluoride on the cerebellar cortex of adult albino rats and the possible protective role of vitamin B6: a light and electron microscopic study
Introduction: Sodium fluoride (NaF) toxicity has been a subject of extensive studies over the last years because of their environmental persistence and world widespread distribution. Its toxicity on many organs has received considerable attention, but its neurotoxicity has not been entirely studied. Aim of the Work: Studying the histological changes occurring
Studies on sural nerve biopsies in endemic skeletal fluorosis
Sural nerve biopsies from 13 patients with radiologically confirmed skeletal fluorosis were studied for myelinated fibre densities, frequency distribution oftheir diameters, and single teased nerve fibre preparations. It was observed that most of the biopsies showed a marked reduction in myelinated fibre densities with more than half of them in:volving
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
Fluoride & IQ: The 64 Studies
As of December 2019, a total of 72 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 64 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
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