SUMMARY: Brain tissues for neurohistopathological study were obtained at
autopsy from albino rabbits that had been subcutaneously injected for 15
weeks with 0, 5, 10, 20, and 50 mg of sodium fluoride in 1 mL of aqueous solu-
tions/kg bw/day. Neuropathological changes occurred with loss of the mo-
lecular layer and glial cell layer in the brain tissues of rabbits exposed to the
three higher fluoride doses. The Purkinje neurones exhibited chromatolysis
and acquired a “ballooned” appearance. Nissl substance showed various de-
grees of decrease and even complete loss. Fragmented particles were re-
tained in the perinuclear zone. The perikaryon showed vacuolization, and
spheroid bodies were present in the neuroplasm. These cytoplasmic inclu-
sions appeared as various sized ovoid bodies or elongated eosinophilic
masses due to which the nucleus was shifted to the periphery. These neuro-
toxic changes in the brain suggested that there was a direct action of fluoride
upon the nerve tissue which was responsible for central nervous system
problems such as tremors, seizures, and paralysis indicating brain dysfunc-
tion seen at the two highest doses.
Effects of drinking water fluorosis on L-type calcium channel of hippocampal neurons in mice.
Highlights Fluoride affects calcium metabolism in mice. Fluoride significantly increases the current peak of the LTCCs. Fluoride reduces the activation voltage of LTCCs. Fluoride delays the inactivation or deactivation of LTCCs. The study aimed to investigate the effects of drinking water fluorosis on L-type calcium channels (LTCCs) in mouse hippocampal neurons.
Decreased nicotinic receptors in PC12 cells and rat brains influenced by fluoride toxicity--a mechanism relating to a damage at the level in post-transcription of the receptor genes
In order to reveal mechanisms of the decreased nicotinic acetylcholine receptors (nAChRs) resulted from fluoride toxicity, we treated PC12 cells by different concentrations of fluoride (0.1-100 ppm) for 48 h, and exposed rats to high doses of fluoride (30 and 100 ppm) in their drinking water for 7 months. The
Effect of fluoride on calcium ion concentration and expression of nuclear transcription factor kappa-B p65 in rat hippocampus
The study investigated the neurotoxicity of drinking water fluorosis in rat hippocampus. Just weaning male Sprague-Dawley (SD) rats were given 15, 30, 60 mg/L NaF solution and tap water for 9 months. The calcium ion concentration ([Ca(2+)]) in synaptosomes was measured by double wavelength fluorescence spectrophotometer and the expression level
Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain
CONTEXT: Quercetin is a well known aglycone flavonoid that is widely found in different food sources. OBJECTIVE: In this study, the in vivo neuroprotective potential of quercetin against sodium fluoride-induced oxidative stress was evaluated. MATERIALS AND METHODS: Wistar rats were divided into five treatment groups and then subjected to daily
Determination of the contents of amino-acid and monoamine neurotransmitters in fetal brains from a fluorosis-endemic area.
The contents of five types of amino-acid neurotransmitters and three types of monoamine neurotransmitters in the brains of fetuses aborted through induced labor in a chronic fluorosis-endemic area were determined. Findings revealed that the content of the excitatory amino acid, aspartic acid, was significantly lower than in the fetuses from
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
Fluoride & IQ: 67 Studies
As of May 2020, a total of 75 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 67 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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