Abstract
Volatile anesthetic agents, such as sevoflurane, are increasingly used for long-term sedation in intensive care units worldwide, with improved clinical outcomes reported in recent studies due to favorable pharmacological properties. Despite possible renal toxicity related to the production of plasma inorganic fluoride and concerns related to reversible impairment of renal concentrating abilities, renal injury associated with sevoflurane sedation has rarely been reported in the intensive care unit setting. We hereby report 3 cases of nephrogenic diabetes insipidus associated with prolonged sevoflurane sedation using the AnaConDa device and review the possible mechanisms of renal toxicity.
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Deterioration of renal function in ICR-derived glomerulonephritis (ICGN) mice by subacute administration of fluoride in drinking water.
Sodium fluoride was administered at 0, 25, 50, 100, and 150 ppm F in drinking water for 4 weeks to Institute of Cancer Research (ICR) derived glomerulonephritis (ICGN) mice. Fluoride was also administered to ICR mice at 0 and 150 ppm. Blood was sampled from the tail artery of each
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Newburgh-Kingston caries-fluorine study. XIII. Pediatric findings after ten years
The onset of menstruation in girls was selected as an index of the rate of sexual maturation, since the menarche is an event which is usually readily dated. The distribution of ages at the nearest birthday at which menstruation first occurred is shown in Table 5. The average age at
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Evaluation of the toxicity of fluorine in Antarctic krill on soft tissues of Wistar rats
Antarctic krill are a potential food source for humans and animals, but krill are known to contain high levels of fluorine (F). In this study, we investigated the toxicity of F in Antarctic krill using Wistar rats. There were three experimental groups: The control group were fed a basal diet,
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Fluoride in drinking water exacerbates glomerulonephritis and induces liver damage in ICR-derived glomerulonephritis mice
To evaluate the effects of fluoride on the kidney and the liver of ICR-derived glomerulonephritis (ICGN) mice by using laboratory tests and pathological examinations, fluoride was administered to the ICGN mice at 0, 25, 50, 100, and 150 ppm in drinking water for 4 weeks and to the ICR mice,
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Chronic toxicity of dietary sodium monofluorophosphate in growing rats, with special reference to kidney changes.
MATERIAL AND METHODS: Male white rats weighing about 100 grams at the start of the experiments were used in the study. They were raised in a standardized way by the Anticimex Co., Stockholm on pellets containing about 28 ppm fluoride and tap water containing about 0.1 ppm fluoride. In a four-week
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Fluoride & Kidney Stones
It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium
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Fluoride Gels & Kidney Function
Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each
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Fluoride as a Cause of Kidney Disease in Animals
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing in
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Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
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Kidney: A potential target for fluoride toxicity
The kidneys are the organ responsible for clearing fluoride from the body. In the process of doing so, the kidneys are exposed to concentrations of fluoride that exceed, by a factor of 50, the concentration of fluoride in human blood. As such, the kidney have long been considered a potential
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