Abstract

Highlights

• Several aspects of fluoride metabolism were examined in child-parent dyads living at a lower- and higher-altitudes in Nepal.
• Fluoride concentration of finger- and toe-nail was not related to either fluoride intake or altitude.
• In children, higher altitude leads to decreased urinary fluoride excretion when given the same fluoride dose.
• In parents, altitude has no significant impact on the proportion of fluoride intake excreted in urine.
• Higher altitude results in higher plasma fluoride concentration in parents when exposed to the same amount of fluoride.

INTRODUCTION: A greater prevalence of dental fluorosis has been reported in higher- versus lower-altitude communities. This study, for the first time, examined several aspects of fluoride metabolism in children, aged 4-5 years, and their parent, living at lower altitude (<78 m) and higher altitude (>1487) areas in Nepal.

METHODS: The study assessed total daily fluoride intake (TDFI), 24 h urinary fluoride excretion (UFE), and fluoride concentrations of toe- and finger-nail (FC_toenail, FC_fingernail) in children and parents as well as fluoride concentration of plasma (FC_plasma) in parents. Fractional urinary fluoride excretion (FUFE) was calculated as the ratio between UFE and TDFI. FC_toenail, FC_fingernail and FC_plasma were normalised for TDFI by dividing the variables by TDFI and the ratio was reported as the percentage.

RESULTS: In total, 89 children and 80 parents took part in the study: 42 children and 41 parents from the lower altitude area; 47 children and 39 parents from the higher altitude area. Fluoride concentration of drinking water was significantly (P <0.001) higher at lower altitude (0.395 mg F/l) than at higher altitude (0.104 mg F/l). TDFI was significantly (p <0.001) higher in both children and parents living in lower altitude than those living at higher altitude. There was a statistically significant (p = 0.044) difference in the mean FUFE of children living at lower altitude (53%) and higher altitude (46%). However, no significant difference in FUFE was found between parents living at lower altitude (47%) compared with higher altitude (41%). In both children and parents, no statistically significant differences in normalised FC_toenail, FC_fingernail were found between the two altitude areas. However, normalised FC_plasma was statistically significantly (P = 0.005) higher in parents living at higher altitude (0.15%) compared with those living at lower altitude (0.11%).

CONCLUSION: The results suggest that higher altitude living results in decreased urinary fluoride excretion, and consequently increased fluoride retention in children for a given dose (amount) of fluoride.

Graphical abstract

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*Original abstract online at https://www.sciencedirect.com/science/article/abs/pii/S0946672X19303645?via%3Dihub

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