Abstract
In 26 adolescents between 13–15 years of age living in a region with increased fluoride concentration in drinking water (3 ppm = 3 mg NaF/l) bone density-measurements by an I-125 profile scanner as well as measurements of thyroid function by means of numerous in vitro tests (T3U, T4, FT4-Index, RIA-T3, rT3, hTg, TSH, thyroglobulin and microsomal thyroid antibodies) have been done. Comparing 19 adolescents of same age from a region with low fluoride concentration in the drinking water (0,1–0,2 ppm) the study showed no influence of fluoride content of drinking water on skeleton mineralization and on thyroid function. There was found only–not depending on fluoride concentration–an increased bone density in females that was interpreted as a physiological difference between males and females.
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Medical aspects of excessive fluoride in a water supply
A 10-year study of 116 persons in Bartlett and 121 in Cameron, Tex., was conducted to determine if prolonged exposure to fluoride in the water supply of Bartlett had produced detectable physiological effects. Bartlett's water contained about 8 p.p.m. F until 1952, when an experimental defluoridation unit was installed, reducing the
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Association between low-to-moderate fluoride exposure and bone mineral density in Chinese adults: Non-negligible role of RUNX2 promoter methylation.
Highlights RUNX2 promotor methylation is positively related to excessive fluoride (F) exposure. Bone mineral density (BMD) is negatively related to excessive F exposure in women. BMD is negatively associated with RUNX2 promotor methylation in women. RUNX2 methylation mediates the association of excessive F exposure and BMD in women. Bone mineral density
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Bone fluoride in proximal femur fractures.
Bone fluoride concentration and bone mineral density (BMD) were evaluated in 51 female patients who had undergone hip arthroplasty due to proximal femur fracture. The hip fractures were divided into 42 neck and head fractures and 9 trochanteric fractures. BMD in the contralateral femoral neck and Ward triangle was determined
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Effects of fluoride on metamorphosis, thyroid and skeletal development in Bufo gargarizans tadpoles
This study examined the effects of chronic fluoride exposure on metamorphosis, thyroid and skeletal development in tadpoles of Chinese Toad, Bufo gargarizans. The tadpoles were exposed to fluoride concentrations either at 0, 1, 5, 10, or at 50 mg L(-1) from Gosner stage 26 to Gosner stage 42. Body weight,
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Fluorosis increases the risk of postmenopausal osteoporosis by stimulating interferon y
Estrogen deficiency in postmenopausal women frequently activates osteoclasts (OC), accelerates bone resorption, and leads to osteoporosis (OP). Previous studies have demonstrated that interferon y (IFNy) could increase bone resorption and may be involved in postmenopausal OP. Fluorosis also increased the risk of fractures and dental fluorosis, and fluoride may enhance osteoclast formation and
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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