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    An Editorial by David C. Bellinger, PhD, MSc Environmental epidemiology is a field replete with controversies, but the intensity of the debate inspired by the fluoridation of municipal water supplies to reduce dental caries is perhaps unrivaled. Governments, as well as individuals, differ in their assessments of water fluoridation as public policy.

  • Fluoride exposure during development affects both cognition and emotion in mice

    Highlights The developmental fluoride exposure to mice affects their emotional behaviors. The developmental fluoride declines both spatial and non-spatial cognition of mice. The high fluoride reduces the exercise tolerance of mice. Previous studies have suggested that sodium fluoride (NaF) may have adverse effects on neurodevelopment. In the present study, we evaluated

  • Behavioral teratology in rats exposed to fluoride.

    A study was conducted of behavioral differences in Wistar rat pups born of dams drinking water containing 1.0, 5.0, and 25 mg F/L from the day of conception. A control group drank tap water containing 0.6 mg F/L. Among 18 litters in the 25 mg/L group, four of the dams

  • SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.

    Rationale: Potential adverse effects of fluoride on neurodevelopment has been extensively explored and mitochondria have been recognized as critical targets. Mitochondrial biogenesis serves a crucial role in maintaining mitochondrial homeostasis and salubrious properties of resveratrol (RSV) has been well-defined. However, the molecular mechanisms governing mitochondrial biogenesis in developmental fluoride neurotoxicity

  • Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada.

    Key Points Question  Is maternal fluoride exposure during pregnancy associated with childhood IQ in a Canadian cohort receiving optimally fluoridated water? Findings  In this prospective birth cohort study, fluoride exposure during pregnancy was associated with lower IQ scores in children aged 3 to 4 years. Meaning  Fluoride exposure during pregnancy may be associated

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    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

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    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out