Abstract

SUMMARY: Adult female Wistar rats were treated daily for 60 days with sodium fluoride (500 ppm NaF = 226 ppm fluoride ion) in drinking water, alone or in combination with vitamin D (200 IU/kg by oral intubation). Throughout the period, food intake was measured daily. Body weight gain, exploratory motor activity (EMA) rota-rod motor coordination, dental structure, brain acetylcholinesterase (AchE) activity, and serum fluoride and serum calcium concentration were determined 24 hr after the last treatment. Serum fluoride concentration increased markedly in the NaF-treated animals and was accompanied by decreased food intake, reduced body weight gain, impairment of EMA and motor coordination, dental lesions, inhibition of brain AchE activity, and hypocalcemia. Administration of vitamin D along with NaF prevented hypocalcemia. However, the toxic action fluoride on motor coordination, brain AchE activity, and the teeth was not prevented in these animals, probably because vitamin D is not able to decrease the level of fluoride in the serum. Therefore, vitamin D has only limited value as a protective dietary factor against chronic toxic effects of fluoride.

• Related Studies :

  • Modulation of fluoride toxicity in rats by calcium carbonate and by withdrawal of fluoride exposure.

    In order to assess the effect of calcium on the toxic effects of fluoride, adult female Wistar rats were treated with sodium fluoride (NaF, 500 ppm in drinking water) alone or in combination with calcium carbonate (CaCO3, 50 mg/kg by oral intubation) daily for 60 days. Food, water and fluoride

  • The association of fluoride in drinking water with serum calcium, vitamin D and parathyroid hormone in pregnant women and newborn infants.

    Background: Chronic exposure to fluoride in drinking water causes an increase in plasma fluoride levels that is related to a reduction in calcium transport across the renal tubule endoplasmic reticulum and plasma membrane. In the present study, it was hypothesised that varying levels of fluoride present in drinking

  • Renal osteodystrophy in patients on long-term hemodialysis with fluoridated water

    Serum and bone fluoride concentrations of ten patients maintained on long-term hemodialysis with fluoridated water (1 ppm, i.e., 50uM) were correlated with duration of treatment and the occurrence of clinical, radiological, and histological manifestations of bone disease. Two patients had symptomatic renal osteodystrophy when accepted on the program, whereas six

  • Effect of fluoride on reactive oxygen species and bone metabolism in postmenopausal women.

    A study was made of the effects of fluoride (F) on the antioxidant defense systems of postmenopausal women residing in a fluorotic and a nonfluorotic village in Chitoor district, Andhra Pradesh, India. Twenty-five postmenopausal women (approximately 10 years postmenopause, mean age 57 years) residing in endemic fluorotic Adharam and nonfluorotic

  • Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats

    Spontaneous motor activity, rota-rod performance (motor co-ordination), body weight gain, food intake, activities of total cholinesterase (blood) and acetylcholinesterase (brain), and dental structure were determined in adult female rats treated with a very high dose of sodium fluoride (500 ppm in drinking water) alone and in combination with calcium carbonate

• Related FAN Content :

  • Nutrient Deficiencies Enhance Fluoride Toxicity

    It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,

  • Fluoride & Rickets

    One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid (unmineralized bone) content of bone. When bones have too much osteoid, they become soft and prone to fracture -- a condition known as osteomalacia. When osteomalacia develops during childhood, it is called "rickets." The potential for fluoride

  • Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients

    Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,

  • Fluoride & IQ: 67 Studies

    As of May 2020, a total of 75 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 67 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or

  • Annapolis: Water Fluoridation Linked to Death of Dialysis Patient

    EVENING CAPITAL (Annapolis, Maryland) November 29, 1979 Fluoride Linked to Death by Mary Ann Kryzankowicz Staff Writer Fluoride poisoning has been definitely linked to the death of a 65-year-old kidney dialysis patient who became ill during a blood cleaning process Nov 11. State Medical Examiner Dr. (illegible) Guard has ruled that Lawrence Blake, 65, of Arundel