Abstract
Summary: Oral administration of sodium fluoride (NaF, 6 and 12 mg/kg body weight/day) to Swiss male albino mice for 30 days caused significant, dose-dependent reduction in DNA, RNA, and protein contents in cerebral hemisphere, cerebellum, and medulla oblongata of the brain. After 30 days of NaF treatment, followed by withdrawal of treatment for 30 days, partial but significant amelioration occurred. Administration of 2% black tea extract alone for 30 days did not cause any significant effect. However, concurrent administrations of NaF and black tea extract for 30 days cause significant amelioration in all parameters studied.
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Mitigation of sodium fluoride induced toxicity in mice brain by black tea infusion.
SUMMARY: In an extension of previous work on fluoride (F) toxicity in a group of 80 Swiss albino mice, the mitigating effects of polyphenols in black tea on the F-induced increase in glycogen, cholesterol, and total lipids in the cerebral hemisphere (CH), cerebellum (CB), and medulla oblongata (MO) regions of
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Black tea extract mitigation of NaF-induced lipid peroxidation in different regions of mice brains.
SUMMARY: As part of our investigation of fluoride toxicity effects in a group of 80 Swiss albino adult male mice, we examined the mitigating effects of black tea extract (BTE) on the F-induced enzymatic and non-enzymatic parameters of oxidative stress in the cerebral hemisphere (CH), cerebellum (CB), and medulla oblongata (MO) of the
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Public-health risks from tea drinking: Fluoride exposure.
Aims: Due to new evidence on fluoride neurotoxicity during early life, this study examined maternal exposure to fluoride through tea consumption in a low-fluoride region and measured fluoride releases from commercially available teas (tea bags and loose teas) to determine the need to limit fluoride exposure. Methods:
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Amelioration by black tea of sodium fluoride-induced changes in protein content of cerebral hemisphere, cerebellum and medulla oblongata in brain region of mice.
Oral administration of sodium fluoride (NaF, 6 and 12 mg/kg body weight/day) to Swiss strain male albino mice for 30 days caused significant dose-dependant reduction in the content of acidic, basic, neutral, and total protein in cerebral hemisphere, cerebellum and medulla oblongata region of brain. After 30 days of NaF
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T for target organ, timing, and fluoride exposure.
Background: The brain is a main target organ for fluoride toxicity during early development. Based on recent epidemiological evidence, an approximate benchmark dose has been calculated for pregnant women at about 0.2 mg/L in water (or urine). This means that current limits for water-fluoride are too high, but tea has
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Fluoride content in tea and its relationship with tea quality.
J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected
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The Lancet: Fluoride Studies in a Patient with Arthritis
It is possible that fluoride intake from tea may be sufficient to cause fluorosis, and I report here a case which gives some evidence for this.
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Tea Intake Is a Risk Factor for Skeletal Fluorosis
A number of recent studies have found that heavy tea drinkers can develop skeletal fluorosis - a bone disease caused by excessive intake of fluoride.
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Exposure Pathways Linked to Skeletal Fluorosis
Excessive fluoride exposure from any source -- and from all sources combined -- can cause skeletal fluorosis. Some exposure pathways , however, have been specifically identified as placing individuals at risk of skeletal fluorosis. These exposure pathways include: Fluoridated Water for Kidney Patients Excessive Tea Consumption High-Fluoride Well Water Industrial Fluoride Exposure Fluorinated Pharmaceuticals (Voriconazole
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