Abstract
Natural iodine deficiency and ambient air pollution with fluorine compounds were examined for their combined influence on the prevalence and severity of iodine-deficiency disorders. The excess intake of fluorine was shown to increase the incidence of thyroid diseases and to lower anthropometric indices in children. The preventive measures performed to eliminate iodine-deficiency disorders under intensive ambient air pollution with fluorine compounds were found to be insufficiently effective.
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Fluoride-induced thyroid cell apoptosis
In addition to causing skeletal and dental fluorosis, fluoride (F) in drinking water may damage other organs including the thyroid. The objective of this study was to explore the toxicity of F on immortalized human normal thyroid cells (Nthy-ori 3-1) exposed to 0, 0.1, 1, and 3 mmol/L of sodium
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[Thyroid gland pathology in children population exposed to the combination of iodine deficiency and fluoride pollution of environment].
The article presents results of study of the impact of iodine deficiency and technogenic fluoride on the state of the thyroid gland in children. On the example of two districts of the city of Bratsk there were executed dynamic investigations (2002 and 2012), including the estimation of the pollution of
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Taurine ameliorates renal oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride
Excessive exposure to fluoride poses several detrimental effects to human health particularly the kidney which is a major organ involved in its elimination from the body. The influence of taurine on fluoride-induced renal toxicity was investigated in a co-exposure paradigm for 45 days using five groups of eight rats each. Group I rats received
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[Expressions of iNOS and VEGF mRNAs in thyroid gland of rat with goiter induced by fluoride].
To investigate the mechanism of goiter caused by fluoride, goiter model of SD rats was produced by administering sodium fluoride in drinking water. Histological section of thyroid gland was made, and inducible nitric oxide synthase (iNOS) and vessel endothelial growth factor (VEGF) were determined by RT-PCR. Results showed that the
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Effect of sodium fluoride on the structure and function of the thyroid and ovary in albino rats (Rattus Norvegicus).
Objective: The objective was to investigate the effect of sodium fluoride (NaF) on the structure and function of the thyroid and ovary in albino rats. Method: Twenty-four female adult albino rats, 160–180 g body weight (bw), were divided into four groups of 6: the control group (I) received defluoridated water while the other
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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NRC (2006): Fluoride's Impact on the Thyroid Gland
Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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