The study was conducted on 25 healthy women residing in optimum fluoride areas, who were to deliver normally through vaginal route, to correlate the maternal and cord plasma fluoride levels and evaluate the placental transfer of fluoride. A wide variation was found in the maternal and cord plasma fluoride levels. In only 8 percent of the cases the fluoride levels in cord plasma were higher than maternal plasma. It was deduced that the placenta allows passive diffusion of fluoride from mother to foetus and does not act as a barrier.
Serum ionic fluoride concentrations are related to renal function and menopause status but not to age in a Japanese general population
BACKGROUND: There have been no studies in which fasting serum ionic fluoride (SIF) concentrations in a general population were investigated despite the fact that SIF has various activities in humans. METHODS: A total of 332 healthy subjects (167 men and 165 women aged 40 to 69years) were selected from residents of
Effect of vitamin D on chronic behavioral and dental toxicities of sodium fluoride in rats.
SUMMARY: Adult female Wistar rats were treated daily for 60 days with sodium fluoride (500 ppm NaF = 226 ppm fluoride ion) in drinking water, alone or in combination with vitamin D (200 IU/kg by oral intubation). Throughout the period, food intake was measured daily. Body weight gain, exploratory motor
Fluoride effects on glutathione peroxidase and lipid peroxidation in rats.
SUMMARY: Eight-week old male Wistar rats weighing 180 g were given sodium fluoride in drinking water at a concentration of 5 and 25 mg F–/L for 12 weeks. Control animals received tap water containing 0.3 mg F–/L. The activity of glutathione peroxidase and the concentration of malondialdehye (MDA) were determined in kidney,
Serum and urine fluoride concentration: relationships to age, sex and renal function in a non-fluoridated population
Serum and urine fluoride levels were determined in 250 healthy subjects (15-90 years, 122 men and 128 women) residing in Catalonia, Spain, and in 150 patients (20-81 years, 84 men and 66 women) with chronic renal failure undergoing regular dialysis treatment, living in the same geographical area, to determine normal
Inorganic plasma fluoride concentrations and its renal excretion in certain physiological and pathological conditions in man
In a study involving 2200 patients the inorganic plasma fluoride concentration (IPFC) increased with increasing age. In a fluoridated (1 ppm) community this increase was more pronounced than in a low fluoride (0.2 ppm) community. The mean renal clearance of fluoride and the daily amounts excreted also increased slightly until
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