Transplacental passage of fluorides was studied in 25 randomly selected neonates. Blood samples collected simultaneously from the mother and the umbilical cord showed that average fluoride concentration in the cord blood was 60% of that in mother’s blood. When concentration in the mother’s blood exceeded 0.4 ppm, the placenta acted as a selective barrier.
Renal osteodystrophy in patients on long-term hemodialysis with fluoridated water
Serum and bone fluoride concentrations of ten patients maintained on long-term hemodialysis with fluoridated water (1 ppm, i.e., 50uM) were correlated with duration of treatment and the occurrence of clinical, radiological, and histological manifestations of bone disease. Two patients had symptomatic renal osteodystrophy when accepted on the program, whereas six
Inorganic plasma fluoride concentrations and its renal excretion in certain physiological and pathological conditions in man
In a study involving 2200 patients the inorganic plasma fluoride concentration (IPFC) increased with increasing age. In a fluoridated (1 ppm) community this increase was more pronounced than in a low fluoride (0.2 ppm) community. The mean renal clearance of fluoride and the daily amounts excreted also increased slightly until
Fluoride exposure and sleep patterns among older adolescents in the United States: a cross-sectional study of NHANES 2015–2016.
Abstract Background Fluoride from environmental sources accumulates preferentially in the pineal gland which produces melatonin, the hormone that regulates the sleep-wake cycle. However, the effects of fluoride on sleep regulation remain unknown. This population-based study examined whether chronic low-level fluoride exposure is associated with sleep patterns and daytime sleepiness among older adolescents
Correlation between plasma and nail fluoride concentrations in rats given different levels of fluoride in water.
Changes in plasma and nail fluoride concentrations in rats given different concentrations of fluoride in drinking water were investigated. Six groups of weanling male Wistar rats were provided drinking water containing NaF at 0, 7, 14, 28, 56, or 100 ppm F- for 42 days. The nails were clipped on
Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers.
Long-term occupational exposure to low level of fluoride can induce oxidative stress and apoptosis in many cells, including lymphocyte. However, the underlying mechanism remains unclear. Hence, this study was designed to explore the potential oxidative stress and apoptosis of long-term occupational exposure to low level of fluoride in aluminum smelter
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