Transplacental passage of fluorides was studied in 25 randomly selected neonates. Blood samples collected simultaneously from the mother and the umbilical cord showed that average fluoride concentration in the cord blood was 60% of that in mother’s blood. When concentration in the mother’s blood exceeded 0.4 ppm, the placenta acted as a selective barrier.
Placental transfer of fluoride in the human fetus at low and high F-intake.
In a previous investigation it was established that in pregnant women drinking water with a medium fluoride concentration, 0.5-0.6 ppm F, the mean F-value of the placenta is significantly higher than that in the cord blood or the maternal blood. The findings under such conditions suggest that the placenta accumulates
Exposure to excessive fluoride during hemodialysis
Discussion These data indicate that a patient maintained by hemodialysis in a community using fluoridated water may be exposed to a fluoride concentration higher than that present in tap water if the deionizer is allowed to become exhausted while the patient is being dialyzed. The concentration reached 520 uM in the
Biochemistry of Fluorosis X - Comparative Study of the Fluoride Levels in Biological Fluids.
The fluoride content of drinking water is directly correlated with the serum and saliva fluoride. Serum fluoride levels are also directly related to those of saliva, but not to urinary fluoride. These interrelations are so close that a mathematical formula can be devised for the calculation of fluoride in body fluids.
Correlation between plasma and nail fluoride concentrations in rats given different levels of fluoride in water.
Changes in plasma and nail fluoride concentrations in rats given different concentrations of fluoride in drinking water were investigated. Six groups of weanling male Wistar rats were provided drinking water containing NaF at 0, 7, 14, 28, 56, or 100 ppm F- for 42 days. The nails were clipped on
Modulation of fluoride toxicity in rats by calcium carbonate and by withdrawal of fluoride exposure.
In order to assess the effect of calcium on the toxic effects of fluoride, adult female Wistar rats were treated with sodium fluoride (NaF, 500 ppm in drinking water) alone or in combination with calcium carbonate (CaCO3, 50 mg/kg by oral intubation) daily for 60 days. Food, water and fluoride
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