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  • Integrated transcriptomic and proteomic analysis indicated that neurotoxicity of rats with chronic fluorosis may be in mechanism involved in the changed cholinergic pathway and oxidative stress.

    Highlights Chronic fluorosis decreased learning and memory of rats and induced neurotoxicity. Thirteen corresponding DEGs and DAPs (cor-DEGs-DAPs) were identified. Most of cor-DEGs-DAPs were related to neurodegenerative changes and oxidative stress response The neurotoxicity by high fluoride involved in the changes in cholinergic pathway and oxidative stress. Background To reveal the

  • Fluoride-induced brain damages in suckling mice

    In order to reveal mechanisms of brain damages resulted from fluoride toxicity, we treated adult female mice of Swiss Albinos strain by 500 ppm NaF (226 ppm F?) in their drinking water from the 15th day of pregnancy until the day 14 after delivery. All mice were sacrificed on day 14 after

  • Black tea amelioration of sodium fluoride-induced alterations of DNA, RNA, and protein contents in the cerebral hemisphere, cerebellum, and medulla oblongata regions of mouse brain.

    Summary: Oral administration of sodium fluoride (NaF, 6 and 12 mg/kg body weight/day) to Swiss male albino mice for 30 days caused significant, dose-dependent reduction in DNA, RNA, and protein contents in cerebral hemisphere, cerebellum, and medulla oblongata of the brain. After 30 days of NaF treatment, followed by withdrawal

  • The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats

    Objective: Explore the effect and possible mechanisms of fluorine exposure of pregnant rats passing through placental barriers on the learning and memory capabilities of baby rats. Method: Open field behavior and a water maze test were used to observe the effects on the spontaneous behavior and learning and memory on baby

  • Changed expressions of N-methyl-D-aspartate receptors in the brains of rats and primary neurons exposed to high level of fluoride

    Expressions of N-methyl-d-aspartic acid receptors (NMDARs) in the brains of rats and primary neurons exposed to high fluoride were investigated. Sprague-Dawley rats were divided randomly into a fluorosis group (50 ppm fluoride in the drinking water for 6 months) and controls (<0.5ppm fluoride) and the offspring from these rats sacrificed

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