BACKGROUND: Recent studies have reported an inverse association between fluoride exposure and IQ in children, but most were ecological in design. Few involved personal measures of exposure or adjusted for confounders.
METHODS: This study utilized archived urine samples and data from offspring who participated in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) pregnancy and birth cohort project to study concurrent fluoride exposure and its association with cognitive outcomes in 565 children ages 7-15 years old. Generalized Additive Models (GAM) were used to test the association between specific gravity-adjusted urinary fluoride levels and total score from the Wechsler Abbreviated Scale of Intelligence (WASI), adjusting for child’s sex, child’s age, gestational age, birth weight, birth order, maternal intelligence score, maternal age, maternal education, marital status, maternal education, maternal smoking history, family possessions, and cohort. GAM were also re-run after stratifying by sex (NMales = 298, NFemales = 267).
RESULTS: Concurrent urinary fluoride was not significantly associated with WASI scores in children, and sex did not modify the association.
CONCLUSIONS: The results of this cross-sectional study do not support the hypothesis that concurrent fluoride exposure has an impact on cognitive function among children aged 7-15 years.
This abstract was presented in ORAL SESSION 14 at the virtual 32nd Conference of ISEE.
B. Thomas, Cornell University Ithaca NY
Lin, Brown University Providence RI
Peterson, University, University of Michigan, Ann Arbor, MI
N. Sanchez, Drexel University, Philadelphia, PA,
Basu, McGill University, Montreal, QC, CANADA
Martinez-Mier, Indiana University, Indianapolis, IN
Mercado-Garcia, Instituto Nacional de Slaud Publica, Cuernavaca, MEXICO
Schnaas, Instituto Nacional de Slaud Publica, Cuernavaca, MEXICO
Till, York University, Toronto, ON, CANADA
Hernandez-Avila, Instituto Nacional de Slaud Publica, Cuernavaca, MEXICO
Hu, University of Washington, Seattle, WA
Tellez-Rojo, Instituto Nacional de Slaud Publica, Cuernavaca, MEXICO