This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause.
as of November 6, 2020
- Pioneer biomonitoring study on rural children to address As and F– co-exposure.
- High dental Fluorosis found in relation to urinary As and F– levels in children.
- Oxidative stress was found associated with lowered intelligence quotient levels.
- No significant difference was observed in the case of genetic polymorphism.
Arsenic (As), and fluoride (F–) are potent contaminants, widely disturbed through drinking water and responsible for various health implications in the exposed population. We aimed to investigate the effects of these two contaminants on dental fluorosis and intelligence quotient (IQ) with the induction of oxidative stress in rural children under the co-exposed scenario. A total of 148 children (5 to 16 years old) from the exposed and control group were incorporated in the study, and samples of biological matrices were collected. Dental fluorosis through Dean’s index and IQ with the help of the Wechsler scale of intelligence (WISC-IV) patterned test were measured. We also monitored malondialdehyde (MDA) and its probable association with antioxidants activity (SOD, CAT, and GR) as a biomarker for oxidative stress. GSTM1/T1 polymorphism was estimated to find their role in the urinary As metabolism. Mean urinary concentration of As (2.70 vs. 0.016 ug/L, P<0.000) and F– (3.27 vs. 0.24 mg/L, P<0.000) were quite higher in the exposed group as well as the frequency of dental fluorosis. The rate of children with lowered IQ cases was less in control than the exposed group. Additionally, lower concentrations of antioxidants (SOD, CAT, and GR) were found suggesting high susceptibility to fluoride toxicity. The percentage for null genotype carriers for GSTT1 was higher in exposure than the control group. The findings indicated that F– was accounted for high variations associated with dental fluorosis, lower intelligence quotient, and higher oxidative stress in children under the co-exposure scenario.
*Original abstract online at https://www.sciencedirect.com/science/article/abs/pii/S0013935120310653?via%3Dihub
Investigation and evaluation on intelligence and growth of children in endemic fluorosis and arsenism areas.
“This study investigated the effects of arsenism and fluorosis on the mental ability (MA) and growth of children living in areas endemic for arsenism, fluorosis , or both. The children were divided into high arsenic/fluoride group (group 1), high fluoride group (group 2), high arsenic group (group 3), and control
Protections against toxicity in the brains of rat with chronic fluorosis and primary neurons exposed to fluoride by resveratrol involves nicotinic acetylcholine receptors.
Highlights Fluorosis decreased learning and memory of rats and increased oxidative stress. The changes above may be associated with the lower expressions of a7 and a4 nAChRs. RSV attenuated the toxic effect by fluorosis, which might involve stimulating nAChRs. Protection of Resveratrol (RSV) against the neurotoxicity induced by high level of
OP V – 2 Prenatal fluoride exposure and neurobehavior among children 1–3 years of age in Mexico
Background/aim Recent studies report an inverse association between fluoride (F) exposure and IQ in children, but few included individual measures of exposure or assessed associations with prenatal exposure using a prospective study design. Methods This study utilised the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohort and archived pregnancy samples
The relationships between thyroid-stimulating hormone and/or dopamine levels in peripheral blood and IQ in children with different urinary iodine concentrations.
Highlights TSH is not related IQ in children with different urinary iodine concentrations. Dopamine in plasma is unrelated to IQ in children with adequate or excessive iodine. Dopamine has positive correlation with intelligence in iodine deficiency group. The interaction between dopamine in plasma and TSH is not related to
Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico
Background: Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures of fluoride exposure, addressed the impact of prenatal exposures or involved more than 100 participants. OBJECTIVE: Our aim was to estimate the association of prenatal exposure to fluoride with
Related Studies :
Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
Fluoride & IQ: 68 Studies
As of February 2021, a total of 76 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 68 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
Diagnostic Criteria for Dental Fluorosis: The TSIF ("Total Surface Index of Fluorosis")
The traditional criteria (the "Dean Index") for diagnosing dental fluorosis was developed in the first half of the 20th century by H. Trendley Dean. While the Dean Index is still widely used in surveys of fluorosis -- including the CDC's national surveys of fluorosis in the United States -- dental
Severe Dental Fluorosis: Perception and Psychological Impact
[caption id="attachment_8879" align="aligncenter" width="550"] Severe fluorosis - Photograph by David Kennedy, DDS[/caption] In its severe forms, dental fluorosis causes highly disfiguring brown and black staining of the teeth, which can cause chronic embarrassment and social anxiety for the impacted child. In 1984, a panel from the National Institute of Mental Health (NIMH) warned
Related FAN Content :