- Fluoride can protect enamel from demineralisation and promote remineralization.
- A sodium fluoride/potassium nitrate/cocamidopropyl betaine dentifrice was examined.
- Compared to a NaF/KNO3/sodium lauryl sulphate/tetrasodium pyrophosphate dentifrice.
- Greater salivary fluoride/calcium ion concentration found with the test dentifrice.
- Formulation excipients may impact fluoride and calcium ion oral cavity retention.
OBJECTIVE: This exploratory, randomised, single-blind, crossover, study evaluated fluoride and calcium ion concentrations and pH following use of one of two 1450 ppm fluoride (NaF), 5% w/w KNO3 dentifrices: (1) test dentifrice (with cocamidopropyl betaine) with an orange juice (OJ) rinse; (2) test dentifrice with a deionized (DI) water rinse or (3) comparator dentifrice (with sodium lauryl sulphate and tetrasodium pyrophosphate) with an OJ rinse.
DESIGN: Eighteen participants used their assigned dentifrice, rinsed with DI water, then expectorate was collected. Sixty min post-brushing, participants rinsed with OJ or DI water then expectorate was collected. Saliva samples were collected pre-brushing and at 1, 5, 10, 15, 30 and 60 min post-brushing and following the 60 min OJ/DI water rinse. The pH of samples was taken.
RESULTS: Significant differences (p < 0.05) were found in salivary fluoride ion concentrations between test and comparator dentifrices at 30 and 60 min and following the 60 min OJ rinse, favouring the former. Significant differences were also found between test and comparator dentifrices for salivary calcium ion concentration at 1, 5 and 10 min (p < 0.0001), favouring the former, and between test or comparator + OJ rinse and test + water rinse (p < 0.005), favouring the latter. No pH differences were shown prior to OJ/water rinse. Products were generally well-tolerated.
CONCLUSIONS: Results confirmed that acid-labile fluoride is released from the oral cavity following a dietary acid challenge and showed that formulation excipients may impact on retention of such.
Editorial assistance with the preparation of manuscript drafts was provided by Juliette Allport, Leading Edge, and Eleanor Roberts, Beeline Science Communications Ltd., both funded by GSK Consumer Healthcare [GlaxoSmithKline]
*Read full text online at https://www.sciencedirect.com/science/article/pii/S0003996920302697#!
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Fluoride Levels in Saliva and Plaque following the Use of High Fluoride and Conventional Dentifrices- a Triple Blinded Randomised Parallel Group Trial.
Context: The comparison of fluoride levels in saliva and plaque following the use of conventional, 2800 and 5000 ppm dentifrices for different time intervals up to 24 hours has not been explored. Aim: The aim of the present study was to assess salivary and plaque fluoride levels at different time intervals
Total fluoride intake and excretion in children up to 4 years of age living in fluoridated and non-fluoridated areas.
Fractional fluoride retention is important during the early years of life when considering the risk of development of dental fluorosis. This study aimed to measure fractional fluoride retention in young children. The objectives were to investigate the relationships between fractional fluoride retention and total daily fluoride intake, age, and body
Salivary fluoride concentration and retention after rinsing with 0.05 and 0.2% sodium fluoride (NaF) compared with a new high F rinse containing 0.32% NaF.
Objective To compare salivary fluoride (F) concentration and F retention after rinsing with a new 0.32% sodium fluoride (NaF) rinse and conventional 0.05 and 0.2% NaF rinses. Methods Seventeen subjects (aged 22–26 years), with normal salivary secretion rates, participated in a double blind, cross-over study. In three separate sessions with a minimum washout
Fluorosis is linked to anaemia.
We report here a simple, easy-to-practice treatment procedure for anaemia, by focusing on withdrawal of fluoride consumption and promotion of nutrients through diet. The approach to improve nutrient intake as supplementation of iron and folic acid or iron tonic does not yield beneficial results. The reason being highly destructive F–
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