- This human study adds to understanding of the effects of exercise on fluoride (F) metabolism.
- F pharmacokinetics following no, light, moderate and vigorous exercise were compared in adults.
- Moderate exercise resulted in the highest maximum plasma F concentration (Cmax).
- Area Under the Curve for plasma F concentration against time was also highest with moderate exercise.
- Moderate exercise may increase the fraction of systemically absorbed F, producing a biological effect.
The literature is sparse in terms of the effect of exercise on the pharmacokinetics of fluoride (F) in humans. In a 4-treatment repeated measures cross-over study, we investigated F pharmacokinetics following no exercise (control) and three exercise intensity conditions (light, moderate and vigorous) in healthy adults. At a pre-experimental session, 8 participants (18-30y) residing in a non-fluoridated-area, underwent a VO2 max test to guide the three exercise intensities for the experimental sessions. Participants were on a F-free regime one week before and throughout the four experimental weeks. We measured urinary F excretion (UFE), maximum plasma concentration (Cmax), lag time of Cmax (Tmax), and Area Under the Curve (AUC) for plasma F concentration against time, following F ingestion then no, light, moderate and vigorous exercise. Results showed no statistically significant difference in Tmax among all sessions; whereas Cmax for moderate exercise (226.2 ng/ml) was significantly higher than for no (27.0 ng/ml; p < 0.001), light (105.6 ng/ml; p = 0.016) and vigorous (94.2 ng/ml; p = 0.008) exercise. Mean AUC over 0–90 min following F ingestion was also significantly higher in moderate exercise than for no (p < 0.001), light (p = 0.004) and vigorous (p = 0.001) exercise. Mean UFE over 0–14h was 638.8, 718.7, 574.6 and 450.5 ?g for no, light, moderate and vigorous exercise, with no statistically significant differences among different sessions. In conclusion, this human experimental study suggests that moderate exercise may increase the fraction of F absorbed systemically which is therefore available to produce a biological effect. Future studies should be conducted with larger samples, different age groups and using different F doses.
*Original abstract and text online at https://www.sciencedirect.com/science/article/pii/S0045653520319913
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Chronic exposure to fluoride is a public health problem worldwide. We explored the relationship between fluoride exposure, orthopedic injuries and bone formation markers alkaline phosphatase (ALP), bone Gla protein (BGP) in participants with coal-burning fluorosis in Hehua Village (coal-burning fluorosis endemic area) in Zhijin County of Guizhou Province and Zhangguan
The tissue distribution of fluoride in a fatal case of self-poisoning.
The purpose of this paper is to report a case of fluoride poisoning along with a discussion of poisoning characteristics, analytical procedures, and a review of previous reports of fatal intoxications with analytical data. A case of suicidal ingestion of 40 mL of a rust removal agent containing hydrofluoric acid
Effect of altitude on urinary, plasma and nail fluoride levels in children and adults in Nepal.
Highlights Several aspects of fluoride metabolism were examined in child-parent dyads living at a lower- and higher-altitudes in Nepal. Fluoride concentration of finger- and toe-nail was not related to either fluoride intake or altitude. In children, higher altitude leads to decreased urinary fluoride excretion when given the same fluoride dose.
Correlative study of fluoride content in urine, serum and urinary calculi
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