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Neurotoxicity induced by Fluoride in Rat Cerebral Cortex
In cerebral cortex of the rats, treated with 100 ppm of sodium fluoride, there was disorganization of granular cell layer. The granule cells were accumulated in the form of clumps. Some pyramidal neurons showed chromatolysis (Fig. 2) and were shrunken with vacuolation around them (Fig. 4). The nuclei of some pyramidal neurons were eccentric in […]
Effect of fluoride on brain of albino-rabbit – An experimental study.
From Table 1: Gross and brain cyto-architecture changes of experimental animals at the end of 16 weeks. Changes in Brain Cytoarchitecture: The neurones lost their angular or pyramidal shape and acquired a plump, ovoid, rounded, or characteristic “ballooned” appearance (Figure 1). The nucleus was displaced to the periphery or axonal base and was shrunken, pyknotic, […]