Tag: Lipid peroxidation
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Neuroligin-3 activates Akt-dependent Nrf2 cascade to protect osteoblasts from oxidative stress.
Introduction Osteoblasts are derived from mesenchymal progenitor cells and are the main functional cells for bone formation [[1], [2], [3]]. They are responsible for the synthesis, secretion and mineralization of bone matrix and can secrete various bioactive substances for bone formation and reconstruction [[1], [2], [3]]. In the pathogenesis of osteoporosis, uncontrolled reactive oxygen species […]
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Effects of chronic fluorosis on the brain.
Highlights Reviewing the mechanism of brain injury caused by chronic fluorosis is of great significance for protecting residents in fluorosis endemic areas. Abstract This article reviews the effects of chronic fluorosis on the brain and possible mechanisms. We used PubMed, Medline and Cochraine databases to collect data on fluorosis, brain injury, and pathogenesis. A large […]
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Self-recovery study of fluoride-induced ferroptosis in the liver of zebrafish (Danio rerio).
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Environmental Toxicity Assessment of Sodium Fluoride and Platinum-Derived Drugs Co-Exposure on Aquatic Organisms.
1. Introduction Fluoride is used in the production of fluoridated dental products as well as it is used in drinking water fluoridation processes [1,2]. The World Health Organization establishes an acceptable level for drinking water, which ranges from 0.7 to 1.0 mg/L-1. However, fluoride concentrations of up to 20 mg have been recorded in some […]
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Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy.
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A review of molecular mechanisms linked to potential renal injury agents in tropical rural farming communities.
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Impact of Chronic Sodium Fluoride Toxicity on Antioxidant Capacity, Biochemical Parameters, and Histomorphology in Cardiac, Hepatic, and Renal Tissues of Wistar Rats.
References 1. Ludlow M, Luxton G, Mathew T (2007) Effects of fluoridation of community water supplies for people with chronic kidney disease. Nephrol Dial Transplant 22:2763–2767. https://doi.org/10.1093/ndt/gfm477 Article PubMed Google Scholar 2. Council NR (2006) Fluoride in drinking water. National Academies Press, Washington, D.C. Google Scholar 3. Ahmed KM, Bhattacharya P, Hasan MA et al […]
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Evaluation of Metformin and Dehydrozingerone against fluorosis induced neurodevelopmental toxicity in preclinical models.
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Prospects for the Role of Ferroptosis in Fluorosis.
As a strong oxidant, fluorine can induce oxidative stress resulting in cellular damage. Ferroptosis is an iron-dependent type of cell death caused by unrestricted lipid peroxidation (LPO) and subsequent plasma membrane rupture. This article indicated a relationship between fluorosis and ferroptosis. Evidence of the depletion of glutathione (GSH) and increased oxidized GSH can be found […]
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3,4-Dihydroxybenzaldehyde mitigates fluoride-induced cytotoxicity and oxidative damage in human RBC.