Tag: RNA
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Fluoride Alters Signaling Pathways Associated with the Initiation of Dentin Mineralization in Enamel Fluorosis Susceptible Mice.
References 1. Fejerskov O, Larsen MJ, Josephsen K, Thylstrup A (1979) Effect of long-term administration of fluoride on plasma fluoride and calcium in relation to forming enamel and dentin in rats. Scand J Dent Res 87(2):98–104 CAS PubMed Google Scholar 2. Vieira A, Hancock R, Dumitriu M, Schwartz M, Limeback H, Grynpas M (2005) How […]
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Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis.
1. Introduction Fluorine is one of the most common halogens, which usually exists in the environment as compounds. Fluorine or fluoride enters the human body primarily through drinking water, food, and air. Once absorbed into the bloodstream, it is easily transported throughout the body in the form of ions. More than 90% of absorbed fluoride […]
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Preliminary screening of fluorine-stained osteoblastic apoptosis-related microRNA.
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Widespread genetic switches and toxicity resistance proteins for fluoride
Abstract Most riboswitches are metabolite-binding RNA structures located in bacterial messenger RNAs where they control gene expression. We have discovered a riboswitch class in many bacterial and archaeal species whose members are selectively triggered by fluoride but reject other small anions, including chloride. These fluoride riboswitches activate expression of genes that encode putative fluoride transporters, […]
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Expression levels of brain nicotinic acetylcholine receptor mRNA and protein in coal-burning type of fluorosis rats.
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Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.
Highlights Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/PTHrP feedback loop during endochondral ossification. Abstract Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride […]
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Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes.
Excerpts: Apoptosis, characterized by nuclear fragmentation, chromatic condensation, and caspase activation, is a major molecular mechanism to eliminate cells (Oropesa-.vila et al. 2017 ). Apoptosis is observed widely in liver diseases (Cui et al. 2018 ; Potz et al. 2016 ). Fluoride, as an exogenous toxicant, has been reported to cause apoptosis in the liver […]
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Effect of fluoride exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosis regulators in PC12 cells.
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Role of IL-17 pathways in immune privilege: a RNA deep sequencing analysis of the mice testis exposure to fluoride
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Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride.
Discussion The objective of this study was to investigate the effects of F oral exposure on T [testosterone] biosynthesis and the neuroendocrine regulation of the HPT axis in male mice. T is one of the endpoint parameters inHTP axis. In this study, reduced serum T concentration replicates our prior report of F-induced decrease in T […]