FLUORIDE ACTION NETWORK PESTICIDE PROJECT

Return to FAN's Pesticide Homepage

Return to CTFT Index Page


CTFT = Chlorotrifluorotoluene,4-,Alpha,Alpha,Alpha- Chemical intermediate in pesticides. NTP.


National Toxicology Program


NTP CHEMICAL REPOSITORY
4-CHLORO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE -IDENTIFIERS =========== *CATALOG ID NUMBER: 000019 *CAS NUMBER: 98-56-6 *BASE CHEMICAL NAME: CHLOROTRIFLUOROTOLUENE,4-,ALPHA,ALPHA,ALPHA- *PRIMARY NAME: 4-CHLORO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE *CHEMICAL FORMULA: C7H4ClF3 *STRUCTURAL FORMULA: ClC6H4CF3 *WLN: GR DXFFF *SYNONYMS: 4-CHLOROBENZOTRIFLUORIDE P-CHLOROBENZOTRIFLUORIDE P-CHLOROTRIFLUOROMETHYLBENZENE P-CHLORO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE (P-CHLOROPHENYL)TRIFLUOROMETHANE P-(TRIFLUOROMETHYL)CHLOROBENZENE -PHYSICAL CHEMICAL DATA ====================== *PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid REPOSITORY: Clear liquid *MOLECULAR WEIGHT: 180.56 *SPECIFIC GRAVITY: 1.34 [058] *DENSITY: 1.353 g/mL [205,269,275] *MP (DEG C): -36 [269,275] *BP (DEG C): 136-138 C [269,275] *SOLUBILITIES: WATER : <1 mg/mL @ 20 C (RAD) DMSO : >=100 mg/mL @ 20 C (RAD) 95% ETHANOL : >=100 mg/mL @ 20 (RAD) METHANOL : Not available ACETONE : >=100 mg/mL @ 20 (RAD) TOLUENE : Not available OTHER SOLVENTS: Not available *VOLATILITY: Vapor pressure: 1 mm Hg @ 0 C; 5 mm Hg @ 24.7 C [038] Vapor density : 6.24 [451] *FLAMMABILITY(FLASH POINT): The flash point data of this chemical is 47 C (117 F) [205,269,275,451]. It is combustible. Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used [058]. *UEL: Not available LEL: Not available *REACTIVITY: This chemical reacts vigorously with oxidizing materials such as permanganates and dichromates [058]. It is incompatible with strong bases [269]. It is also incompatible with sodium dimethyl sulfonate [066]. *STABILITY: This chemical is sensitive to heat and light [058]. *OTHER PHYSICAL DATA: Refractive index: 1.4463 @ 20 C [205,269,275]; 1.4431 @ 30 C [047] Freezing point: -36 C [062] Aromatic odor [062] Vapor pressure: 10 mm Hg @ 37.1 C, 20 mm @ 50.6 C, 760 mm Hg @ 152.2 C [038] -TOXICITY ======== *NIOSH REGISTRY NUMBER: XS9145000 *TOXICITY: (abbreviations) typ. dose mode specie amount units other LC50 ihl mus 20 gm/m3 LC50 ihl rat 22 gm/m3 LD50 orl mus 11500 mg/kg LD50 orl rat 13 gm/kg *AQTX/TLM96: Not available *SAX TOXICITY EVALUATION: THR: Only slightly toxic to experimental animals by skin contact and oral routes. *CARCINOGENICITY: Status: NTP Carcinogenesis Studies; selected, January 1988 *MUTATION DATA: test lowest dose | test lowest dose ---------- ------------------ | ------------ ----------------- dns-hmn:emb 1 gm/L | *TERATOGENICITY: Not available *STANDARDS, REGULATIONS & RECOMMENDATIONS: OSHA: None ACGIH: None NIOSH Criteria Document: None NFPA Hazard Rating: Health (H): None Flammability (F): None Reactivity (R): None *OTHER TOXICITY DATA: Standards and Regulations: DOT-IMO: Flammable or Combustible liquid; Label: Flammable liquid Status: EPA TSCA Chemical Inventory, 1986 EPA TSCA Test Submission (TSCATS) Data Base, March 1988 -OTHER DATA (Regulatory) ======================= *PROPER SHIPPING NAME (IATA): Chlorobenzotrifluorides *UN/ID NUMBER: UN2234 *HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III *LABELS REQUIRED: Flammable liquid *PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L *SPECIAL PROVISIONS: None *USES: This compound is used as a dye intermediate, chemical intermediate, solvent and dielectric fluid. *COMMENTS: Not available -HANDLING PROCEDURES =================== *ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes and respiratory system [058,269]. It is also extremely destructive to tissue of the mucous membranes [269]. It is harmful if swallowed, inhaled or absorbed through the skin [269]. High vapor concentrations cause anesthesia [058]. When heated to decomposi- tion it emits toxic fumes of hydrogen fluoride, hydrogen chloride and possibly organic fluorides [058]. It also emits toxic fumes of carbon dioxide and carbon monoxide [269]. *MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. *RECOMMENDED GLOVE MATERIALS: GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical: This chemical has not been tested for permeation by Radian Corporation; however, the GlovES+ expert system was used to extrapolate permeation test information from compounds in the same chemical class. The GlovES+ system uses permeation data from literature sources; therefore, extra safety margins should be used with the estimated protection time(s). If this chemical makes direct contact with your glove, or if a tear, puncture or hole develops, replace them at once. The GlovES+ expert system is a tool that can help people better manage protection from chemicals, however this tool cannot replace sound judgment nor make technical decisions. Our GlovES+ expert system is designed to offer initial advice and assistance in glove selection while the final glove selection should be made by knowledgeable individuals based on the specific circumstances involved. Glove Type Model Number Thickness Estimated Protection Time Nitrile Edmont 37-165 0.60 mm 240 min PVA Edmont 15-552 0.07 mm 480 min Viton North F-091 0.25 mm 480 min Unknown North Silvershield 0.10 mm 480 min *RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH- approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. Splash proof safety goggles should be worn while handling this chemical. Alternatively, a full face respirator, equipped as above, may be used to provide simultaneous eye and respiratory protection. *OTHER: Not available *STORAGE PRECAUTIONS: You should store this material in a refrigerator. *SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. *DISPOSAL AND WASTE TREATMENT: Not available -EMERGENCY PROCEDURES ==================== *SKIN CONTACT: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. *INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Respirator Recommendation. *EYE CONTACT: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. *INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. *SYMPTOMS: Symptoms of exposure to this compound include local irritation to skin, eyes and respiratory system, central nervous system depression and dermatitis due to defatting of the skin [058]. Other symptoms include coughing, wheezing, a burning sensation, laryngitis, shortness of breath, headache, nausea, vomit- ing, lung irritation, chest pain, edema (which may be fatal), and irritation to mucous membranes [269]. -SOURCES ======= *SOURCES: [015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects of Chemical Substances. Microfiche Ed. National Institute for Occupational Safety and Health. Cincinnati, OH. Quarterly Updates. XS9145000. [026] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed. Chapman and Hall. New York. Vol. 2, p. 102, #C-20174. [038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds. Industrial and Engineering Chem. 39(4):517-550. 1947. p. 525. [047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on Organic Compounds. CRC Press, Inc. Boca Raton, FL. 1985. Vol. I, p. 262, #B02386. [058] Information Handling Services. Material Safety Data Sheets Service. Microfiche Ed. Bimonthly Updates. October/November 1988. 6607-007, G-09. [062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987. p. 264. [066] Bretherick, L. Handbook of Reactive Chemical Hazards. 3rd Ed. Butterworths. London. 1985. pp. 652, 1531. [082] U.S. Environmental Protection Agency, Office of Toxic Substances. Toxic Substances Control Act Chemical Substance Inventory: 1985 Edition. 5 Vols. U.S. Environmental Protection Agency. Washington, D.C. January 1986. Listed. [110] Oak Ridge National Laboratory. Environmental Mutagen Information Center (EMIC), Bibliographic Data Base. Oak Ridge National Laboratory. Oak Ridge, TN. Not listed. [120] Oak Ridge National Laboratory. Environmental Teratogen Information Center (ETIC), Bibliographic Data Base. Oak Ridge National Laboratory. Oak Ridge, TN. Not listed. [205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed. McGraw-Hill Book Company. New York. 1985. p. 7-202, #c92. [269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data. Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985. p. 377, #B. [275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI. 1988. p. 326, #C2,640-2. [451] National Fire Protection Association. Fire Protection Guide on Hazardous Materials. 9th Ed. National Fire Protection Association. Quincy, MA. 1986. p. 325M-25. [610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to Industrial Chemicals Covered Under Major Federal Regulatory and Advisory Programs. Roytech Publications, Inc. Burlingame, CA. 1990. Section 3, p. 33. [620] United States National Toxicology Program. Chemical Status Report. NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990. Listed. -------------------------------------------------------------

Return to NTP Home Page
NTP welcomes your e-mail comments and suggestions.
Please send them to: NTP Webmaster (ntpwm@niehs.nih.gov)
Last revised: 25 July 2001