Anemia or Anaemia: a
deficiency of red blood cells
aplastic anaemia, aplastic
anemia - anemia characterized by pancytopenia
resulting from failure of the bone marrow; can be caused
by neoplasm or by toxic exposure
erythroblastosis fetalis
- severe anemia in newborn babies; the result of Rh incompatibility
between maternal and fetal blood; typically occurs when
the child of an Rh-negative mother inherits Rh-positive
blood from the father; can be diagnosed before birth by
amniocentesis
congenital pancytopenia,
Fanconi's anaemia, Fanconi's anemia -
a rare congenital anemia characterized by pancytopenia and
hypoplasia of the bone marrow
favism
- anemia resulting from eating fava beans; victims have
an inherited blood abnormality and enzyme deficiency
haemolytic anaemia, hemolytic
anemia - anemia resulting from destruction
of erythrocytes
hyperchromic anaemia, hyperchromic
anemia - anemia characterized by an
increase in the concentration of corpuscular hemoglobin
hypochromic anaemia, hypochromic
anemia - anemia characterized by a
decrease in the concentration of corpuscular hemoglobin
hypoplastic anaemia, hypoplastic
anemia - anemia resulting from inadequately
functioning bone marrow; can develop into aplastic anemia
iron deficiency anaemia,
iron deficiency anemia
- a form of anemia due to lack of iron in the diet or to
iron loss as a result of chronic bleeding
ischaemia, ischemia
- local anemia in a given body part sometimes resulting
from vasoconstriction or thrombosis or embolism
macrocytic anaemia, macrocytic
anemia - anemia in which the average
size of erythrocytes is larger than normal
microcytic anaemia, microcytic
anemia - anemia in which the average
size of erythrocytes is smaller than normal
malignant anaemia, malignant
anemia, pernicious anaemia, pernicious anemia -
a chronic progressive anemia of older adults; thought to
result from a lack of intrinsic factor (a substance secreted
by the stomach that is responsible for the absorption of
vitamin B12)
refractory anaemia, refractory
anemia - any of various anemic conditions
that are not successfully treated by any means other than
blood transfusions (and that are not associated with another
primary disease)
crescent-cell anaemia, crescent-cell
anemia, drepanocytic anaemia, drepanocytic anemia, sickle-cell
anaemia, sickle-cell anemia, sickle-cell disease -
a congenital form of anemia occurring mostly in blacks;
characterized by abnormal blood cells having a crescent
shape
blood disease, blood disorder
- a disease or disorder of the blood
Ref: http://www.thefreedictionary.com/Anemia
|
The
use of high doses increases the likelihood that potentially
significant toxic effects will be identified. Findings of
adverse effects in any one species do not necessarily indicate
such effects might be generated in humans. From a conservative
risk assessment perspective however, adverse findings in
animal species are assumed to represent potential effects
in humans, unless convincing evidence of species specificity
is available.
--
Food and Agricultural Organization of the United Nations
|
Note:
This is not an exhaustive list.
When time allows more information will be added.
Acifluorfen,
sodium -
Herbicide - CAS No. 62476-59-9
-- Increased liver
and kidney weights occurred in chronic rat, mouse, and dog studies
and were accompanied by microscopic liver and kidney changes in
the chronic rat and dog studies. Anemia
was present in chronic rat and dog studies. Stomach ulcers
were found in chronic rat and mouse studies. Testicular atrophy
occurred in the chronic rat study. Increased mortality occurred
in the high-dose group in rat and mouse studies.
Ref:
January 15, 2002. Preliminary Human Health Risk Assessment. MEMORANDUM
SUBJECT: SODIUM ACIFLUORFEN. HED Chapter for the Reregistration
Eligibility Decision Document. US EPA, Office of Prevention, Pesticides
and Toxic Substances. http://www.fluorideaction.org/pesticides/acifluorfen.na.a.red.jan.02.pdf
Benthiavalicarb-isopropyl
- Fungicide -
CAS
No. 177406-68-7
• In the 13-week
feeding study with mice, the dose levels were 0, 50, 200,
7,000, or 20,000 ppm. The NOAEL was 200 ppm (equivalent to 33.0
mg/kg/day and 45.2 mg/kg/day in males and females, respectively,
based on systemic
toxicity of decreased body weights, anemias,
and generalized liver toxicity at 7,000 ppm.
Ref: March 9, 2005. Petition
for the establishment of Tolerances on Imported Grapes and Tomatoes.
Federal Register: March 9, 2005.
Chlorfenapyr
-
Acaracide, Insecticide - CAS No. 122453-73-0
-- MRID No. 42770219
(1993)-- 90-Day oral toxicity rats.
NOAEL = 24.1 mg/kg/day. LOAEL = 48.4, based on spongiform myelopathy
in the brain and spinal cord of male rats,
decreased body weight gain and increased relative liver weight
in males and females, increased absolute liver weight in females,
and decreased hemoglobin in females.
-- MRID No. 43492837 (1994). Combined chronic/ carcinogenicity
in rat. NOAEL = 15 mg/kg/day, males.
LOAEL = 30.8 mg/kg/day, males, based on
anemia. NOAEL = 3.6 mg/kg/day, females LOAEL = 18.6 mg/kg/day,
females, based on decreased body weight/
body weight gain.
Ref:
Federal Register: September 26, 2003. Chlorfenapyr; Pesticide
Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/chlorfenapyr.fr.sept26.2003.htm
Clodinafop-propargyl
-
Herbicide - CAS No. 105512-06-9
Clodinafop-propargyl induces anaemia in
all tested species, peroxisome proliferation in rodents
and increases in inflammation with indications of immunosuppression
and fat reduction in dogs. The dose levels at which severe effects
were seen in rats and mice in the longest studies do not warrant
classification. However, severe effects were seen in dogs at a
dose level requiring classification with R48/22.
Ref: Classification of clodinafop-propargyl
with R48/22. The Netherlands, May 2005.
http://www.fluorideaction.org/pesticides/clodinafop-prop.may.2005.html
Cryolite
- Insecticide - CAS No. 15096-52-3
-- CHRONIC FLUORINE
POISONING OCCURS AMONG MINERS OF CRYOLITE/ LOSS OF WEIGHT, ANOREXIA,
ANEMIA, WASTING ... AND DENTAL DEFECTS
ARE AMONG COMMON FINDINGS IN CHRONIC FLUORINE POISONING. THERE
MAY BE AN EOSINOPHILIA, AND IMPAIRMENT OF GROWTH IN YOUNG WORKERS.
SYMPTOMS OF INTOXICATION INCLUDE GASTRIC, INTESTINAL, CIRCULATORY,
RESP AND NERVOUS COMPLAINTS AND SKIN RASHES. [Sax, N.I. Dangerous
Properties of Industrial Materials. 6th ed. New York, NY: Van
Nostrand Reinhold, 1984. 1427]
-- Chronic poisoning: Intake of more than 6 mg of fluoride per
day results in fluorosis. Symptoms are weight loss, brittleness
of bones, anemia, weakness, general
ill health, stiffness of joints. ... /Fluoride/ [Dreisbach, R.
H. Handbook of Poisoning. 9th ed. Los Altos, California: Lange
Medical Publications, 1977. 207]
Ref: TOXNET from Hazardous Substances Data
Bank for ALUMINUM SODIUM FLUORIDE (Cryolite).
http://www.fluoridealert.org/pesticides/cryolite.toxnet.hsdb.htm
Diflufenzopyr
- Herbicide - CAS No. 109293-97-2
Dietary exposure. EPA
has established the reference dose (RfD) for diflufenzopyr at
0.26 milligrams/kilogram/day (mg/kg/day). This RfD is based on
bone marrow compensated hemolytic anemia
observed in the 1- year dog feeding study with a NOAEL of 26 mg/kg/day
and an uncertainty factor of 100.
Ref: Federal Register: December 12, 2001
(Volume 66, Number 239) [Notices] [Page 64257-64262]. Notice of
Filing a Pesticide Petition to Establish a Tolerance fora Certain
Pesticide Chemical in or on Food. http://www.fluoridealert.org/pesticides/diflufenzopyr.fr.dec12.2001.htm
Etoxazole
- Acaricide - CAS No. 153233-91-1
-- Subchronic toxicity.
Effects observed at high dose levels consisted primarily of
anemia and histological changes in the adrenal
gland, liver and kidneys.
Ref: August 13, 2003. [Federal Register:
August 13, 2003 (Volume 68, Number 156)] [Notices]. Etoxazole;
Notice of Filing a Pesticide Petition to Establish a Tolerance
for a Certain Pesticide Chemical in or on Food.
http://www.fluorideaction.org/pesticides/etoxazole.fr.aug.13.2003.htm
Floransulam
- Herbicide - CAS No. 145701-23-1
Short
term toxicity. Target / critical effect:
Anemia, hepatotoxicity
, renal hypertrophy epithelial cells, collecting ducts,
adrenal vacuolation(dog ) Lowest
relevant oral NOAEL / NOEL: 1 y & 90 d dog (oral feed) ; 5 mg/kg
bw/d;...
Ref: September 18, 2002 - Review report
for the active substance florasulam. European Commission Health
& Consumer Protection Directorate-General.
http://www.fluoridealert.org/pesticides/florasulam.eu.sept.2002.pdf
Flufenpyr-ethyl
- Herbicide - CAS No. 188489-07-8
-- 870.4200. Carcinogenicity
rodents (mouse). NOAEL = 39.9 - 43.7 mg/kg/day M/F LOAEL = 401.8
- 447.9 mg/kg/day M/F, based on liver toxicity in both sexes and
mild anemia in males No evidence
of carcinogenicity.
Ref:
Federal Register: September 19, 2003. Flufenpyr-Ethyl; Pesticide
Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/flufenpyr-ethyl.fr.sept2003.htm
-- Mice.
In a 4-week study, CD-1 mice were fed pure flufenpyr- ethyl
at dose levels of 0, 300, 1,000, 3,000, and 7,000 ppm. Effects
were slight anemia, changes
in blood biochemistry...
-- Mice. In a 13-week study, flufenpyr-ethyl
technical was administered to mice at dose levels of 0, 300, 1,000,
3,000, and 7,000 ppm. Slight anemia and
blood biochemistry changes
were noted...
Ref:
Federal Register: June 25, 2003 (Volume 68, Number 122)] [Notices]
[Page 37813-37820]. Flufenpyr-ethyl; Notice of Filing a Pesticide
Petition to Establish a Tolerance for a Certain Pesticide Chemical
in or on Food.
http://www.fluorideaction.org/pesticides/flufenpyr-ethyl.fr.june.03.htm
Flumioxazin
- Herbicide - CAS No. 103361-09-7
-- Subchronic toxicity.
Subchronic toxicity studies conducted with flumioxazin technical
in the rat (oral and dermal), mouse and dog indicate a low level
of toxicity. Effects observed at high dose levels consisted primarily
of anemia and histological changes
in the spleen, liver and bone marrow related
to the anemia.
-- Rats. A 90-day subchronic toxicity study was conducted in rats,
with dietary intake levels of 0, 30, 300, 1,000 and 3,000 ppm
flumioxazin technical (98.4% purity). The NOAEL of 300 ppm was
based on decreased bwts; anemia;
increases in absolute and/or relative liver, kidney, brain, heart,
and thyroid weights, and histological changes in the spleen, liver,
and bone marrow related to the anemia.
-- A second 90-day subchronic toxicity study was conducted with
a sample of flumioxazin technical of typical purity (94.8%) at
dietary concentrations of 0, 30, 300, 1,000, and 3,000 ppm. The
NOAEL was 30 ppm based on anemia and related
hematological changes; increases in liver, heart, kidney,
and thyroid weights; and histological changes in the spleen, liver,
and bone marrow related
to the anemia.
Ref: Federal Register: February 14, 2001
[Notices] [Page 10292-10301]. Notice of Filing a Pesticide Petition
to Establish a Tolerance for a Certain Pesticide Chemical in or
on Food.
http://www.fluoridealert.org/pesticides/flumioxazin.fr.feb.14.2001.htm
Fluorouracil
- Former
insect Chemosterilant; now used as a pharmaceutical
- CAS No. 51-21-8
Major toxic effects
result from myelosuppressive action. Clinical effects are leukopenia,
thrombocytopenia, and anemia. Loss
of hair, occasionally progressing to total alopecia, nail changes,
dermatitis, and increased pigmentation and atrophy of skin may
occur.
Ref: TOXNET profile from Hazardous Substances
Data Base for FLUOROURACIL.
http://www.fluoridealert.org/pesticides/fluorouracil.toxnet.hsdb.htm
Fluthiacet-methyl
- Herbicide - CAS No. 117337-19-6
Carcinogenicity in
rats. NOAEL males = 2.1 mg/kg/day LOAEL in males = 130 mg/kg/day
NOAEL in females = 2.5 mg/kg/day LOAEL in females = 154 mg/kg/day.
In males there were decreased body weight, liver toxicity,
pancreatic toxicity and microcytic anemia.
In females there were liver toxicity,
uterine toxicity and slight microcytic anemia.
In males only at 130 and 219 mg/kg/day there was respectively,
an increase in the trend toward pancreatic exocrine adenomas and
pancreatic islet cell adenomas.
Ref: Federal Register. December 21, 2001.
Fluthiacet-methyl; Pesticide Tolerance. Final Rule.
http://www.epa.gov/fedrgstr/EPA-PEST/2001/December/Day-21/p31497.htm
Fluvalinate
- Acaricide, Insecticide - CAS No. 69409-94-5
Dietary administration
of 2.5 mg/kg/day to rats for 13 weeks produced anemia
in blood parameters (decreased hematocrit,
hemaglobin, and red blood cells).
The NOEL was 1.0 mg/kg/day. Dietary administration of 30 mg/kg/day
(LOEL) to rats for 3 months produced decreased hemoglobin, hematocrit,
and red blood cell count in rats. The NOEL was 3 mg/kg/day...
EPA believes that there is sufficient evidence for listing fluvinate
on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based
on the available developmental, dermal, and hematological toxicity
data for this chemical.
Ref:
USEPA/OPP. Support Document for the Addition of Chemicals from
Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active
Ingredients to EPCRA Section 313. U. S. Environmental Protection
Agency, Washington, DC (1993). As cited by US EPA in: Federal
Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition
of Certain Chemicals; Toxic Chemical Release Reporting; Community
Right-to-Know; Proposed Rule.
Indoxacarb
- Insecticide - CAS No. 173584-44-6
A mammalian chronic
feeding Lowest Observable Effect Concentration (LOEC) Ms. was
exceeded at the highest predicted vegetation residue level. Residue
levels under field conditions will be lower as no foliar precipitation
wash-off or dilution due to growth was factored into the screening
modeling. Furthermore, the most sensitive reported end points
are used for the Department's risk assessments. In this case the
threshold exceeded was for hemolytic
effects, specifically anemia. While
these effects would reduce an individual animal's fitness should
they feed exclusively on treated vegetation, lethal or reproductive
effect thresholds are not reached and population level effects
are unlikely.
Ref: March 21, 2002 letter from N.Y. State
Department of Conservation, Division of Solid & Hazardous Materials,
Bureau of Pesticides Management Pesticide, Product Registration
Section to E.I. du Pont de Nemours and Company, Inc. Re: Registration
of DuPontTM AvauntŪ Insecticide (EPA Reg. No. 352-597) Containing
the New Active Ingredient Indoxacarb.
http://www.fluoridealert.org/pesticides/indoxacarb.ny.mar.21.2002.htm
--
**52425-047 162215 "Chronic
Toxicity Study of DPX-JW062-106 (50% DPX-KN128, 50% DPX-KN127)
One Year Feeding Study in Dogs" (Mertens, J. 831-WIL Research
Laboratories, Inc. Ashland, Ohio. Study HLO 885-96, 11/19/97).
DPX-JW062-106 technical (Batch DPX-JW062- 106, 47.5% DPX-KN128)
was administered orally (via the feed) to 5 Beagle dogs/sex/dose
at levels of 0, 40, 80, 640 and 1280 ppm for 52 weeks. There was
a treatment-related decrease in body weight, body weight gain
and food consumption in 1280 ppm dogs during the first three months
of the study. Reduced mean hemoglobin, RBC count and hematocrit
was noted in the 80, 640 and 1280 ppm groups during all periods
tested; increased Heinz bodies in these groups indicated hemolysis.
Increased mean reticulocyte counts and MCV and decreased corpuscular
hemoglobin concentration, erythrocyte morphologic changes and
increased mean platelet counts indicated responses to hemolytic
anemia. Significantly decreased RBC counts were also reported
in 40 ppm males at week 25 and 51. Females at 40 ppm also showed
reductions in RBC, but the differences were not statistically
significant. Mean liver weights were increased in males (640 and
1280 ppm groups) and females (1280 ppm only). Microscopic changes
in groups 40 ppm and above included increased pigment (hemosiderin)
in liver Kupffer cells, kidney tubule epithelium, spleen and bone
marrow and increased extramedullary hematopoiesis in the spleen
and bone marrow hyperplasia. NOEL (M/F)=40 ppm (males: 1.1 mg/kg/day;
females: 1.3 mg/kg/day based on biologically
significant hemolytic anemia at 80 ppm and above). Acceptable.
Kellner, 1/12/99.
Ref:
March
11, 1999: Summary
of Toxicology Data - Indoxycarb.
California EPA Department of Pesticide Regulation, Medical Toxicology
Branch.
http://www.fluorideaction.org/pesticides/indoxacarb.ca.epa.1999.pdf
Novaluron
- Insecticide - CAS
No. 116714-46-6
From
Table 2.--Summary of Toxicological Dose and Endpoints for novaluron
for Use in Human Risk Assessment:
--
Chronic
dietary (All populations);
Long-term inhalation (>6 months) and
Long-term dermal (>6months).
Combined chronic toxicity carcinogenicity feeding in rat LOAEL
= 30.6 mg/kg/day based on erythrocyte damage and turnover resulting
in a regenerative anemia.
Re: June 2, 2004. Novaluron; Pesticide Tolerance.
Final Rule. Federal Register.
http://www.fluoridealert.org/pesticides/novaluron.fr.june.2.2004.htm
Oxyfluorfen
- Herbicide - CAS No. 42874-03-3
Human
Health Assessment. Toxicity, Oxyfluorfen is of low acute oral,
dermal, and inhalation toxicity. The primary toxic effects are
alterations in blood parameters (anemia)
and in the liver. Oxyfluorfen is classified as a possible human
carcinogen based on combined hepatocellular adenomas/carcinomas
in the mouse carcinogenicity study. A cancer potency factor (Q1*)
was used to estimate human risk. The FQPA Safety Factor for protection
of infants and children was reduced to 1X for all population subgroups
as there was no increased susceptibility in animals due to pre-
or post-natal exposure to oxyfluorfen.
-- Toxicity was similar for subchronic and
chronic rat, mouse, and dog studies in both sexes. Oxyfluorfen
inhibits heme production, which
results in a variety of anemias. Heme is the part of the
hemoglobin molecule that contains iron and binds oxygen. In the
1997 subchronic rat study which used the current 98% a.i. formulation,
the red blood cell count was normal, but the red blood cell mass
was decreased due to the small size of the red blood cells, presumably
because of inhibition of the protoporphyrinogen oxidase enzyme.
The anemia was generally mild in other studies, with varying
hematologic abnormalities described in the rat, mouse, and dog
studies.
-- It should be noted that older
toxicity studies with oxyfluorfen used technical material of approximately
71% or 85% purity. The newer toxicity studies used a technical
material of approximately 98% purity, which is the basis for the
current registrations of oxyfluorfen. The newer technical material
has similar impurities to the older technical material, but in
reduced concentrations. Toxicity was less severe for studies with
the 98% product than for the 71% product; however,
one mammal developmental study with the 98% technical was submitted
in which animals experienced the most severe anemia and related
hematologic effects of any of the mammalian studies. When
there were studies with both the new and old technical material,
preference for an endpoint for risk assessment purposes was generally
given to the newer, 98% technical material (current registrations).
Ref: US EPA Reregistration Eligibility Decision (RED) OXYFLUORFEN.
EPA738-R-02-014 October 2002.
http://www.epa.gov/oppsrrd1/REDs/oxyfluorfen_red.pdf
Picolinafen
- Herbicide - CAS No. 137641-05-5
-- In the rat 2-generation
reproduction study, reproduction function, reproductive parameters
and litter parameters were not influenced by treatment in the
first and second generation (P1/P2) parental animals at any dose
level up to and including 500 ppm (equal to 39 and 42 mg/kg bw/d
in males and females, respectively), the highest dose tested.
Hematological findings, increased
spleen weights, and histopathological findings indicative of
regenerative hemolytic anemia were noted for P1/P2 males
and females at 250 ppm (equal to 19 and 21 mg/kg bw/d for males
and females, respectively) and above. Hematological findings including
lower red blood cell count, hemoglobin,
and hematocrit were also noted for male and female second
generation (F2) pups at 250 ppm and above on lactation day 21
(only time point evaluated). Although the hematological findings
noted in the F2 offspring may be secondary to maternal toxicity,
a direct treatment-related effect cannot be dismissed; therefore,
these findings were considered to be toxicologically relevant.
The NOAEL for parental and offspring toxicity was 50 ppm (equal
to 3.7 and 4.0 mg/kg bw/d in males and females, respectively).
On the basis of the parental and offspring NOAELs in the rat 2-generation
reproductive toxicity study (one litter/generation), there was
no indication that neonates were quantitatively more sensitive
than adults to the toxic effects of picolinafen.
-- Hematological and histopathological findings indicative of
regenerative hemolytic anemia were noted
in all species tested. The most sensitive species appears
to be the rat. The most appropriate NOAEL for regenerative hemolytic
anemia is 50 ppm (equal to 2.4 and 3.0 mg/kg bw/d for males and
females, respectively), as determined in the 2-year rat dietary
study. The MOE for regenerative hemolytic anemia is 171 compared
to the ADI.
Ref:
February 17, 2003 - Canada. Picolinafen. Regulatory Note REG2003-02.
Alternative Strategies and Regulatory Affairs Division, Pest Management
Regulatory Agency.
http://www.fluorideaction.org/pesticides/picolinafen.canada.feb.2003.pdf
Primisulfuron-methyl
- Fungicide,
Herbicide - CAS
No. 86209-51-0
In a 90-day dog feeding
study, reduced thyroid weights accompanied by colloid depletion
and parafollicular hyperplasia and anemia were observed at the
LOEL of 25 mg/kg/day. The NOEL was 0.625 mg/kg/day. In a 1-year
dog study, dietary administration of 250/125 mg/kg/day (LOEL:
the dose was changed after week 10 in the study) produced thyroid
hyperplasia, anemia, increased
platelet levels, vacuolar changes, and increased absolute
and relative liver weights. The NOEL was 25 mg/kg/day. In an 18-month
study in mice, dietary administration of 1.7 mg/kg/day produced
increased absolute and relative liver weights in females. No NOEL
was established...
Ref:
USEPA/OPP. Support Document for the Addition of Chemicals from
Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active
Ingredients to EPCRA Section 313. U. S. Environmental Protection
Agency, Washington, DC (1993). As cited by US EPA in: Federal
Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition
of Certain Chemicals; Toxic Chemical Release Reporting; Community
Right-to-Know; Proposed Rule.
Sodium
bifluoride - Insecticide, Former US EPA
List 3 Inert -
CAS No.
1333-83-1
Effects of Overexposure.
Inhalation of dust or mist may cause severe mucous membrane irritation,
burns and, with prolonged or repeated exposure, may
cause fluorosis. Eye and skin exposure causes irritation
and burns. Product may be absorbed through the skin and
produce signs of fluorosis such as
weight loss, brittleness of bones, anemia,
weakness and stiffness of joints. Ingestion is harmful
due to acid burns and fluoride poisoning. Internal bleeding may
develop. Effects may not be immediately apparent, especially with
dilute solutions.
Ref:
Material Safety Data Sheet for Sodium bifluoride. Rev. March 29,
1996. Chemtech Products, Inc., St. Louis MO 63131
http://www.fluorideaction.org/pesticides/sodium.bifluoride.msds.1996.pdf
CHRONIC EXPOSURE -
Hydrogen fluoride and hydrofluoric acid are extreme irritants
to any part of the body that they contact. The main route of exposure
to hydrogen fluoride is inhalation, followed by dermal contact
for acute exposure and ingestion for chronic exposure. Symptoms
of the chronic effects of hydrofluoric acid include weight
loss, malaise, anemia, leukopenia,
discoloration of teeth, and osteosclerosis.
Ref:
Hazardous Substances Data Bank for SODIUM HYDROGEN DIFLUORIDE
CASRN:
1333-83-1 http://www.fluorideaction.org/pesticides/sodium.bifluoride.toxnet.htm
Sodium
fluorosilicate
(Sodium Hexafluorosilicate) - Insecticide;
Wood Preservative; EPA List 3 Inert - CAS No. 16893-85-9
Toxicological Data
Human Data Chronic exposure to sodium hexafluorosilicate dust
at levels above the eight-hour TWA can result in severe calcification
of the ribs, pelvis, and spinal column ligaments; effects on the
enzyme system; pulmonary fibrosis; stiffness; irritation of the
eyes, skin, and mucous membranes; weight loss; anorexia; anemia;
cachexia; wasting; and dental effects. Long-term or repeated exposure
to the skin can result in skin rash. A probable oral lethal dose
of 50-500 mg/kg, classified as very toxic, has been reported for
a 150-pound (70-kg) person receiving between 1 teaspoon and 1
ounce of sodium hexafluorosilicate.
Ref:
Review of Toxicological Literature. October 2001. Sodium Hexafluorosilicate
[CASRN 16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4].
Prepared for Scott Masten, Ph.D. National Institute of Environmental
Health Sciences P.O. Box 12233 Research Triangle Park, North Carolina
27709. Contract No. N01-ES-65402. Submitted by Karen E. Haneke,
M.S. (Principal Investigator) Bonnie L. Carson, M.S. (Co-Principal
Investigator) Integrated Laboratory Systems P.O. Box 13501 Research
Triangle Park, North Carolina 27709.
http://www.fluoridealert.org/pesticides/fluorosilicates.nih.2001.pdf
Sulfentrazone -
Herbicide - CAS No. 122836-35-5
Subchronic toxicity.
A 90-day subchronic toxicity study was conducted in rats, with
dietary intake levels of 0, 3.3, 6.7, 19.9, 65.8, 199.3, or 534.9
mg/kg/day for males and 0, 4, 7.7, 23.1, 78.1, 230.5, or 404.3
mg/kg/day for females respectively. NOAELs of 19.9 mg/ kg/day
in males and 23.1 mg/kg/day in females were based on clinical
anemia.
Ref: Federal Register, March 7, 2003 (Volume
68, Number 45)] [Notices] [Page 11096-11100]. Notice of Filing
Pesticide Petitions to Establish Tolerances for a Certain Pesticide
Chemical in or on Food.
http://www.fluoridealert.org/pesticides/sulfentrazone.fr.mar.7.2003.htm
-- 90-Day oral toxicity
rodents (rats) - [870.3100] NOAEL = 19.9 milligrams/kilogram/day
(mg/ kg/day) for males and 23.1 mg/kg/ day for females LOAEL =
65.8 mg/kg/ day for males and 78.1 mg/kg/day for females based
on clinical signs of anemia (reduced
hematocrit, hemoglobin, mean cell volume, and mean cell hemoglobin
values during treatment)
-- Chronic toxicity dogs - [870.4100] NOAEL = 24.9 mg/kg/day for
males and 29.6 mg/kg/day for females LOAEL = 61.2 mg/kg/ day for
males and 61.9 mg/kg/day for females based on compensated normochromic
microcytosis
Ref:
Federal Register: September 24, 2003. Sulfentrazone; Pesticide
Tolerances. Final Rule.
http://www.fluorideaction.org/pesticides/sulfentrazone.fr.sept24.03.htm
•
Normochromic definition:
Being normal
in colour; referring especially to red blood cells that possess
the normal quantity of haemoglobin.
• Microcytosis definition:
a blood disorder characterized by the presence of microcytes (abnormally
small red blood cells) in the blood; often
associated with anemia.
Trifloxysulfuron-sodium
- Herbicide - CAS No. 199119-58-9
90-Day oral toxicity
in nonrodents (dogs). NOAEL: 19.8/19.6
mg/kg/day (M/F) LOAEL: 164.2/167.3 mg/kg/day (M/F):
M = decreased
body weight gain (20%), slight hematological effects, clinical
chemistry changes suggesting hepatotoxicity, decreased thymus
weight, thymic atrophy, increased glycogen in liver, hemorrhage
in mesenteric lymph nodes; F = decreased body weight gain (44%),
anemia
with extramedullary hematopoiesis in liver/ spleen and
myeloidhyperplasia in bone marrow, clinical chemistry changes
suggesting hepatotoxicity, decrease thymus
weight, thymic atrophy and hyaline tubular change in kidney.
Ref:
Federal Register: September 17, 2003 (Volume 68, Number 180)]
Rules and Regulations. Trifloxysulfuron; Pesticide Tolerance.
Final Rule.
http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm
Triflumizole
- Fungicide - CAS No. 68694-11-1
--
Chronic toxicity nonrodents (dog): LOAEL = Males: 34.10 mg/kg/day;
Females: 35.17 mg/ kg/daybased on increased alkaline phosphatase
activity and a mild, macrocytic anemia in
males, increased absolute and relative liver weights in
both sexes, and on macroscopic findings in the liver of both sexes.
Ref: Federal Register: June 12, 2002. Triflumizole;
Pesticide Tolerance. Final Rule. http://www.fluoridealert.org/pesticides/triflumizole.fr.june12.2002.htm
Trifluralin
- Herbicide - CAS No. 1582-09-8
• Long term toxicity (Annex IIA, point 5.5). Target/critical
effect. Body weight
reduction, anemia,
liver & kidney
effects (mouse, rat). (page 46).
Ref: March 14, 2005.
European
Food Safety Authority:
Conclusion regarding the peer review
of the pesticide risk assessment of the active substance trifluralin.
EFSA Scientific Report (2005) 28, 1-77.
http://www.fluoridealert.org/pesticides/trifluralin.eu.long.2005.pdf
Triflusulfuron-methyl
- Herbicide - CAS No. 126535-15-7
Two 90-day studies
were conducted in the rat. In one study, rats were fed dosages
of 6.2, 127, 646, or 965 mg/kg/day (males) or 7.54, 150, 774,
or 1,070 mg/kg/day (females). Triflusulfuron methyl exhibited
subchronic toxicity at dietary concentrations of 2,000 ppm (127
and 150 mg/kg/day for males and females) or greater in the form
of decreased body weights, decreased body weight gains, decreased
food efficiency, increased mean relative liver weights, and regenerative
anemia. The NOAEL was 6.2 mg/kg/day
(males) and 7.54 mg/kg/day (females).
Ref: Federal Register: August 8, 2001 (Volume
66, Number 153)] [Notices] [Page 41593-41597]. Notice of Filing
a Pesticide Petition to Establish a Tolerance for a Certain Pesticide
Chemical in or on Food.
http://www.fluoridealert.org/pesticides/triflusulfuron.m.fr.aug8.01.htm
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