|
Return
to Flutolanil Index Page
Activity: Fungicide
(benzanilide)
Structure:
Adverse
Effects:
Body
Weight Decrease
Bone
Brain
Cholesterol
Endocrine:
Thyroid
Eye
Liver
Spleen
Environmental
As
of February 16, 2005, this fungicide is permitted in
or on 43 food commodities
in the United States - see list at bottom of page.
|
Body
Weight Decrease (click
on for all fluorinated pesticides)
A rabbit developmental
study with a maternal NOEL of 5 mg/kg/day and a maternal LOEL
of 25 mg/kg/day based on histopathological finds in the liver
and a developmental NOEL of 25 mg/kg/day and a developmental LOEL
of 125 mg/kg/day based on increased skeletal
variations... Reproductive
and developmental toxicity... A rat developmental study with a
maternal NOEL of 25 mg/kg/day and with a maternal LOEL of 125
mg/kg/day based on decreased body weight
gain initially and a developmental NOEL of 25 mg/kg/day
and a developmental LOEL of 125 mg/kg/day based on decreased
fetal body weight, delayed development [mainly delays in
ossification in the skull, vertebrae, sternebrae, and appendages],
and an increase in the incidence of extra ribs. A rabbit developmental
study with a maternal NOEL of 5 mg/kg/day and a maternal LOEL
of 25 mg/kg/day based on histopathological finds in the liver
and a developmental NOEL of 25 mg/kg/day and a developmental LOEL
of 125 mg/kg/day based on increased skeletal variations.
Ref: Federal Register. June 23, 1998. [PF-813;
FRL-5795-1]
http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
Bone
(click
on for all fluorinated pesticides)
A rabbit developmental
study with a maternal NOEL of 5 mg/kg/day and a maternal LOEL
of 25 mg/kg/day based on histopathological finds in the liver
and a developmental NOEL of 25 mg/kg/day and a developmental LOEL
of 125 mg/kg/day based on increased skeletal
variations... Reproductive and developmental toxicity...
A rat developmental study with a maternal NOEL of 25 mg/kg/day
and with a maternal LOEL of 125 mg/kg/day based on decreased body
weight gain initially and a developmental NOEL of 25 mg/kg/day
and a developmental LOEL of 125 mg/kg/day based on decreased fetal
body weight, delayed development [mainly delays
in ossification in the skull, vertebrae, sternebrae, and appendages],
and an increase in the incidence of extra
ribs. A rabbit developmental study with a maternal NOEL
of 5 mg/kg/day and a maternal LOEL of 25 mg/kg/day based on histopathological
finds in the liver and a developmental NOEL of 25 mg/kg/day and
a developmental LOEL of 125 mg/kg/day based on increased
skeletal variations.
Ref: Federal Register. June 23, 1998. [PF-813;
FRL-5795-1] http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
Brain
(click on for all fluorinated
pesticides)
Chronic toxicity. A
1-year dog chronic feeding study with a NOEL was 40 ppm [1.29
mg/kg/day in males and 1.14 mg/kg/day in females] and a LOEL of
800 ppm [27.75 mg/kg/day in males and 26.82 mg/kg/day in females]
based on increased alkaline phosphatase, kidney, and liver weight
in both sexes, increased cholesterol in males, decreased T2, T4
and ALT values in both sexes, and increased
incidences of microscopic lesions in the brain,
eye,
kidney, spinal cord, sciatic nerve and liver.
Federal Register: June 23, 1998 [Page 34176-34184].
Notice of Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
Cholesterol
(click on for all fluorinated
pesticides)
Chronic toxicity. A
1-year dog chronic feeding study with a NOEL was 40 ppm [1.29
mg/kg/day in males and 1.14 mg/kg/day in females] and a LOEL of
800 ppm [27.75 mg/kg/day in males and 26.82 mg/kg/day in females]
based on increased alkaline phosphatase, kidney, and liver weight
in both sexes, increased cholesterol in
males, decreased T2, T4 and ALT values in both sexes, and
increased incidences of microscopic lesions in the brain, eye,
kidney, spinal cord, sciatic nerve and liver.
Ref: Federal Register: June 23, 1998 [Page
34176-34184]. Notice of Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
Endocrine:
Thyroid
(click on for all fluorinated
pesticides)
Subchronic toxicity.
A 84-day rat feeding study with a No Observed Effect Level ( NOEL)
less than 100 ppm [6.0 mg/kg/day] for males and a NOEL of 100
ppm [7.2 mg/kg/day] for females and with a Lowest Observed Effect
Level (LOEL) of 100 ppm [6.8 mg/kg/day] for males based on suppression
of thyroxine (T4) level and a LOEL of 400 ppm [28.8 mg/kg/day]
for females based on hematology and clinical chemistry findings.
A 13-week mouse feeding study with a NOEL of 100 ppm [18.2 mg/kg/day
for males and 24.5 mg/kg/day for females] and a LOEL of 400 ppm
[64.2 mg/kg/day for males and 91.3 mg/kg/day for females] based
on histopathology of the liver, spleen and thyroid.
A 13-week dog dietary study with a NOEL of 50 ppm [1.70 mg/kg/day
for males and 1.67 mg/kg/day for females] and a LOEL of 200 ppm
[6.90 mg/ kg/day for males and 7.20 mg/kg/day for females] based
on evidence that the bio-transformation capacity of the liver
has been exceeded, (as indicated by increase in LDH, liver weight,
ALK and hepatomegaly), globulin and spleen pigment in females,
decreased T4 and [[Page 34180]] ALT
values in both sexes, decreased albumin in males, and decreased
serum glucose in females. A 21-day rabbit dermal study with the
dermal irritation NOEL of 1,000 mg/kg/day for males and females
and a systemic NOEL of 20 mg/kg/day for males and 150 mg/kg/day
for females and a systemic LOEL of 150 mg/kg/day for males
and 1,000 mg/kg/day for females based on clinical chemistry data
(decreased T4 and FT4 levels in both
sexes) and centrilobular hepatocytomegaly in females.
Ref: Federal Register: June 23, 1998 [Page
34176-34184]. Notice of Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
Eye
(click on for all fluorinated
pesticides)
Chronic toxicity. A
1-year dog chronic feeding study with a NOEL was 40 ppm [1.29
mg/kg/day in males and 1.14 mg/kg/day in females] and a LOEL of
800 ppm [27.75 mg/kg/day in males and 26.82 mg/kg/day in females]
based on increased alkaline phosphatase, kidney, and liver weight
in both sexes, increased cholesterol in males, decreased T2, T4
and ALT values in both sexes, and increased incidences of microscopic
lesions in the brain, eye, kidney,
spinal cord, sciatic nerve and liver.
Federal Register: June 23, 1998 [Page 34176-34184].
Notice of Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
Liver
(click
on for all fluorinated pesticides)
A rabbit developmental
study with a maternal NOEL of 5 mg/kg/day and a maternal LOEL
of 25 mg/kg/day based on histopathological finds in the liver
and a developmental NOEL of 25 mg/kg/day and a developmental LOEL
of 125 mg/kg/day based on increased skeletal variations.
Ref: Federal Register. June 23, 1998. [PF-813;
FRL-5795-1]
http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
Subchronic
toxicity. A 84-day rat feeding study with a No Observed Effect
Level ( NOEL) less than 100 ppm [6.0 mg/kg/day] for males and
a NOEL of 100 ppm [7.2 mg/kg/day] for females and with a Lowest
Observed Effect Level (LOEL) of 100 ppm [6.8 mg/kg/day] for males
based on suppression of thyroxine (T4) level and a LOEL of 400
ppm [28.8 mg/kg/day] for females based on hematology and clinical
chemistry findings. A 13-week mouse feeding study with a NOEL
of 100 ppm [18.2 mg/kg/day for males and 24.5 mg/kg/day for females]
and a LOEL of 400 ppm [64.2 mg/kg/day for males and 91.3 mg/kg/day
for females] based on histopathology of the liver, spleen
and thyroid. A 13-week dog dietary study with a NOEL of 50 ppm
[1.70 mg/kg/day for males and 1.67 mg/kg/day for females] and
a LOEL of 200 ppm [6.90 mg/ kg/day for males and 7.20 mg/kg/day
for females] based on evidence that the bio-transformation capacity
of the liver has been exceeded, (as indicated by increase in LDH,
liver weight, ALK and hepatomegaly), globulin and
spleen pigment in females, decreased T4 and [[Page 34180]]
ALT values in both sexes, decreased albumin in males, and decreased
serum glucose in females. A 21-day rabbit dermal study with the
dermal irritation NOEL of 1,000 mg/kg/day for males and females
and a systemic NOEL of 20 mg/kg/day for males and 150 mg/kg/day
for females and a systemic LOEL of 150 mg/kg/day
for males and 1,000 mg/kg/day for females based on clinical
chemistry data (decreased T4 and FT4 levels in both sexes) and
centrilobular
hepatocytomegaly
in females.
Ref:
Federal Register: June 23, 1998 [Page 34176-34184]. Notice of
Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
Spleen
(click
on for all fluorinated pesticides)
Subchronic
toxicity. A 84-day rat feeding study with a No Observed Effect
Level ( NOEL) less than 100 ppm [6.0 mg/kg/day] for males and
a NOEL of 100 ppm [7.2 mg/kg/day] for females and with a Lowest
Observed Effect Level (LOEL) of 100 ppm [6.8 mg/kg/day] for males
based on suppression of thyroxine (T4) level and a LOEL of 400
ppm [28.8 mg/kg/day] for females based on hematology and clinical
chemistry findings. A 13-week mouse feeding study with a NOEL
of 100 ppm [18.2 mg/kg/day for males and 24.5 mg/kg/day for females]
and a LOEL of 400 ppm [64.2 mg/kg/day for males and 91.3 mg/kg/day
for females] based on histopathology of the liver, spleen
and thyroid. A 13-week dog dietary study with a NOEL of 50 ppm
[1.70 mg/kg/day for males and 1.67 mg/kg/day for females] and
a LOEL of 200 ppm [6.90 mg/ kg/day for males and 7.20 mg/kg/day
for females] based on evidence that the bio-transformation capacity
of the liver has been exceeded, (as indicated by increase in LDH,
liver weight, ALK and hepatomegaly), globulin and
spleen pigment in females, decreased T4 and [[Page 34180]]
ALT values in both sexes, decreased albumin in males, and decreased
serum glucose in females. A 21-day rabbit dermal study with the
dermal irritation NOEL of 1,000 mg/kg/day for males and females
and a systemic NOEL of 20 mg/kg/day for males and 150 mg/kg/day
for females and a systemic LOEL of 150 mg/kg/day for males and
1,000 mg/kg/day for females based on clinical chemistry data (decreased
T4 and FT4 levels in both sexes) and centrilobular hepatocytomegaly
in females.
Ref:
Federal Register: June 23, 1998 [Page 34176-34184]. Notice of
Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/Flutolanil.FR.June.23.1998.htm
| Environmental
(click
on for all fluorinated pesticides)
Flutolanil
is very persistent
and moderately mobile
Aqueous Photolysis: Flutolanil
degraded slowly, 8% over the 30-day study. No half-life
was indicated.
Aerobic Soil Metabolism: Flutolanil
had a half-life in sandy loam of 300 days.
Anaerobic Aquatic
Metabolism: Flutolanil had a half-life
of >13 years.
Ref:
December 19, 2002. New York State Department of Environmental
Conservation. Letter - Registration of a Major Label Change
- Flutolanil (Moncoat).
http://www.fluoridealert.org/pesticides/Flutolanil.NYDEC.Dec.2002.htm
"Flutolanil
66332-96-5 Banned. Low degradability.
1995."
Definition: "Banned. A substance
which for health or environmental reasons by an authority
decision is either no longer approved for any area of application,
or for which an approval or registration has been denied
from the first instance."
Ref: Euopean Commission.
Appendix 5. Substances which may not be included as active
ingredients in approved pesticide products, Chapter 15,
Section 2, subsection one.
http://www.kemi.se/lagar_eng/pdf/app5_8.pdf
|
| A
February
16, 2005,
check at the Code
of Federal Regulations for Flutolanil: this fungicide is
permitted in or on 43 food
commodities in the United States.
The
following list identifies these crops for which EPA has set
pesticide tolerances. |
| [Code
of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.484]
[Page 474]
TITLE 40--PROTECTION OF ENVIRONMENT
CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)
PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE
CHEMICALS
IN FOOD--Table of Contents
Subpart C_Specific Tolerances
Sec. 180.484 Flutolanil (N-(3-(1-methylethoxy)phenyl)-2-(trifluoromethyl)
benzamide); tolerances for residues.
(a) General. (1) Permanent tolerances. Tolerances are established
for residues of flutolanil, N-(3-(1-methylethoxy)phenyl)-2-
(trifluoromethyl)benzamide, and its
metabolites converted to 2-
(trifluoromethyl) benzoic acid and calculated as flutolanil
in or on the
following raw agricultural commodities: |
| Commodity |
As
of
October 3,
2003
PPM |
As
of
February 16,
2005
PPM |
CFR |
| Cattle,
fat |
0.10 |
0.10 |
180.484
|
| Cattle,
kidney |
1.00 |
1.00 |
180.484
|
| Cattle,
liver |
2.00 |
2.00 |
180.484
|
| Cattle,
meat byproducts |
0.05 |
0.05 |
180.484
|
| Cattle,
meat |
0.05 |
0.05 |
180.484
|
| Egg |
0.05 |
0.05 |
180.484
|
| Goat, fat |
0.10 |
0.10 |
180.484
|
| Goat, kidney |
1.00 |
1.00 |
180.484
|
| Goat, liver |
2.00 |
2.00 |
180.484
|
| Goat, meat
byproducts |
0.05 |
0.05 |
180.484
|
| Goat, meat |
0.05 |
0.05 |
180.484
|
| Goat, milk |
Not
Listed |
0.05 |
180.484
|
| Hog, fat |
0.10 |
0.10 |
180.484
|
| Hog, kidney |
1.00 |
1.00 |
180.484
|
| Hog, liver |
2.00 |
2.00 |
180.484
|
| Hog, meat
byproducts |
0.05 |
0.05 |
180.484
|
| Hog, meat |
0.05 |
0.05 |
180.484
|
| Hog, milk |
Not
Listed |
0.05 |
180.484
|
| Horse,
fat |
0.10 |
0.10 |
180.484
|
| Horse,
kidney |
1.00 |
1.00 |
180.484
|
| Horse,
liver |
2.00 |
2.00 |
180.484
|
| Horse,
meat byproducts |
0.05 |
0.05 |
180.484
|
| Horse,
meat |
0.05 |
0.05 |
180.484
|
| Horse,
milk |
Not
Listed |
0.05 |
180.484
|
| Milk |
0.05 |
0.05 |
180.484
|
| Peanut
hay |
15.0 |
15.0 |
180.484
|
| Peanut
meal |
1.0 |
1.0 |
180.484
|
| Peanut |
0.5 |
0.5 |
180.484
|
| Potato
|
0.20 |
0.20 |
180.484
|
| Potato,
wet peel |
0.30 |
0.30 |
180.484
|
| Poultry
(including turkeys), fat |
0.05 |
0.05 |
180.484
|
| Poultry
(including turkeys), meat byproducts |
0.05 |
0.05 |
180.484
|
| Poultry
(including turkeys), meat |
0.05 |
0.05 |
180.484
|
| Rice, bran |
10.0 |
10.0 |
180.484
|
| Rice, grain |
7.0 |
7.0 |
180.484
|
| Rice, hulls |
25.0 |
25.0 |
180.484
|
| Rice, straw |
10.0 |
10.0 |
180.484
|
| Sheep,
fat |
0.10 |
0.10 |
180.484
|
| Sheep,
kidney |
1.00 |
1.00 |
180.484
|
| Sheep,
liver |
2.00 |
2.00 |
180.484
|
| Sheep,
meat |
0.05 |
0.05 |
180.484
|
| Sheep,
meat byproducts |
0.05 |
0.05 |
180.484
|
| Sheep,
milk |
Not
Listed |
0.05 |
180.484
|
| (2)
Time-limited tolerances. Time-limited tolerances are established
for the residues of the fungicide flutolanil
N-(3-(1-
methylethoxy)phenyl)-2-(trifluoromethyl)benzamide and
its metabolites
converted to 2-(trifluoromethyl) benzoic acid and calculated
as
flutolanil in or on the following agricultural commodities: |
| Commodity |
PPM |
Expiration/
Revocation Date |
Rice, grain
|
2.0
|
12/31/00 |
| Rice, straw |
8.0 |
12/31/00 |
| Rice, bran |
3.0 |
12/31/00 |
| Rice, hulls |
7.0 |
12/31/00 |
| (b)
Section 18 emergency exemptions. [Reserved]
(c) Tolerances with regional registrations. [Reserved]
(d) Indirect or inadvertent residues. [Reserved] |
|
