Adverse Effects
Trifloxysulfuron sodium
CAS No.
199119-58-9

 
 

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Activity: Herbicide (Sulfonylurea)
Structure for "Trifloxysulfuron"



Adverse Effects:
Anemia
Bladder
Blood

Body Weight Decrease
Bone
CNS
Endocrine: Testicular
Endocrine: Thymus
Heart
Kidney
Liver
Lung
Lymph Node
Spleen
Environmental

On September 3, 2003, US EPA approved 49 food tolerances for residues of trifloxysulfuron, which were requested by Syngenta Crop Protection, Inc. - see list of food commodities below.

Anemia (click on for all fluorinated pesticides)

90-Day oral toxicity in nonrodents (dogs). NOAEL: 19.8/19.6 mg/kg/day (M/F) LOAEL: 164.2/167.3 mg/kg/day (M/F): M = decreased body weight gain (20%), slight hematological effects, clinical chemistry changes suggesting hepatotoxicity, decreased thymus weight, thymic atrophy, increased glycogen in liver, hemorrhage in mesenteric lymph nodes; F = decreased body weight gain (44%), anemia with extramedullary hematopoiesis in liver/ spleen and myeloidhyperplasia in bone marrow, clinical chemistry changes suggesting hepatotoxicity, decrease thymus weight, thymic atrophy and hyaline tubular change in kidney.
Ref: Federal Register: September 17, 2003 (Volume 68, Number 180)] Rules and Regulations. Trifloxysulfuron; Pesticide Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm

Bladder (click on for all fluorinated pesticides)

Chronic toxicity dogs NOAEL: 51.1/45.3 mg/kg/day (M/F) LOAEL: 123/121 mg/kg/day (M/F): M = gray- white foci in lungs, fibrous thickening of lung pleura, equivocal decreased body weight gain; F = equivocal increased incidence and severity of chronic urinary bladder inflammation.
Ref: Federal Register: September 17, 2003 (Volume 68, Number 180)] Rules and Regulations. Trifloxysulfuron; Pesticide Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm

Blood (click on for all fluorinated pesticides)

-- The main hazards associated with repeat exposure to product are systemic effects (effects on liver, haematopoietic system and testes). No worker exposure data were available for trifloxysulfuron sodium or ENVOKE HERBICIDE. NOHSC used UK POEM to estimate mixer/loader and applicator exposure. The repeat dose risk assessment indicated that workers should wear elbow- length PVC gloves when preparing spray.
-- Dogs were given trifloxysulfuron at doses of 0, 50, 200 or 500 mg/kg bw/day in gelatin capsules for 28 days. There were no mortalities, changes in food consumption, clinical signs of toxicity or effects on body weight gain. A white material in the faeces of animals at 500 mg/kg bw/day was confirmed by analysis to be the test material. Red blood cell count, haematocrit, haemoglobin, platelet counts and clotting times, plasma bilirubin, protein and albumin were lower and globulin and chloride were higher in both sexes at 500 mg/kg bw/day. Plasma bilirubin was also lower in females at 200 mg/kg bw/day and plasma potassium and calcium were lower in males at 500 mg/kg bw/day...
Ref: August 2002 -
Evaluation of the new active Trifloxysulfuron-sodium in the product ENVOKE HERBICIDE. Public Release Summary. National Registration Authority for Agricultural and Veterinary Chemicals 2002 ISSN1443-1335.
http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Eval.02.pdf

-- Subchronic toxicity. Trifloxysulfuron-sodium technical was evaluated in a number of subchronic studies. In a 3-month rat feeding study the NOAEL was 65.7 mg/kg with hematologic and liver effects noted. In a 3-month mouse feeding study, the NOAEL was 67.9 mg/kg. Effects seen were adaptive liver effects. In a 3-month feeding study in dogs the NOAEL was 19.6 mg/kg and hematopoietic and liver effects were seen. In a 28-day dermal (rat) study, the NOAEL was 100 mg/kg. In this study only body weight effects were noted, and only occurred at 1,000 mg/kg.
-- Chronic toxicity. Trifloxysulfuron-sodium technical was not oncogenic in rats or mice. In a 12-month feeding study in dogs fed diets containing trifloxysulfuron-sodium that resulted in average (sexes combined) daily test substance intakes of 0, 1.67, 6.71, 15.0, 48.2 or 122 mg/kg/day, all animals survived... There was a tendency for a decrease in the erythrocyte count, hemoglobin concentration and hematocrit for both sexes at 122 mg/kg/day at the end of treatment, and for males throughout the treatment period... Administration of trifloxysulfuron-sodium to dogs for 12 months caused a tendency for decrease in red blood cell parameters in both sexes at 122 mg/kg/day. There was neither histopathological nor functional evidence for compound related neurotoxicity. Based on the effects at 48.2 and 122 mg/kg/day, the NOAEL was established at 15.0 mg/kg/day for males and 14.9 mg/kg/day for females.
Ref: Federal Register: March 21, 2003. Trifloxysulfuron-sodium; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food.
http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Mar21.03.htm

Body Weight Decrease (click on for all fluorinated pesticides)

-- In the rat teratology study, 300 and 1,000 mg/kg/day caused maternal toxicity consisting of reduced body weight and food consumption. Developmental toxicity was secondary to maternal toxicity and consisted of slightly reduced fetal body weights and an increase in minor skeletal anomalies and variations. The NOAELs for maternal and developmental toxicity were both 30 mg/kg/day...
-- Chronic toxicity. Trifloxysulfuron-sodium technical was not oncogenic in rats or mice. In a 12-month feeding study in dogs fed diets containing trifloxysulfuron-sodium that resulted in average (sexes combined) daily test substance intakes of 0, 1.67, 6.71, 15.0, 48.2 or 122 mg/kg/day, all animals survived... The body weight gain was decreased by 16% in males at 122 mg/kg/ day. The 33% decrease at 48.2 mg/kg/day was mainly due to one male that gained significantly less weight than the other animals of this group. There was a tendency for a decrease in the erythrocyte count, hemoglobin concentration and hematocrit for both sexes at 122 mg/kg/day at the end of treatment, and for males throughout the treatment period. In female dogs treated with 48.2 and 122 mg/kg/day, the mean absolute and relative liver weights were increased, and a tendency for an increase in relative liver weight was noted for males at the same dose levels. The maximum tolerance dose (MTD) was achieved at 122 mg/kg/day based on the decrease in the body weight gain in males at 48.2 and 122 mg/kg/day. Administration of trifloxysulfuron-sodium to dogs for 12 months caused a tendency for decrease in red blood cell parameters in both sexes at 122 mg/kg/day. There was neither histopathological nor functional evidence for compound related neurotoxicity. Based on the effects at 48.2 and 122 mg/kg/day, the NOAEL was established at 15.0 mg/kg/day for males and 14.9 mg/kg/day for females.
-- In a 90-day subchronic neurotoxicity study in rats, trifloxysulfuron-sodium was not neurotoxic when administered in the diet for 13 weeks at concentrations resulting in average daily test substance intakes of 0, 112, 472, or 967 mg/kg/day for males or 0, 134, 553 or 1,128 mg/kg/day for females... Based on body weight effects, the NOAEL was established at 112 mg/kg/day for male rats and 553 mg/kg/day for female rats.
Ref: Federal Register: March 21, 2003. Trifloxysulfuron-sodium; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food.

http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Mar21.03.htm

90-Day oral toxicity in nonrodents (dogs). NOAEL: 19.8/19.6 mg/kg/day (M/F) LOAEL: 164.2/167.3 mg/kg/day (M/F): M = decreased body weight gain (20%), slight hematological effects, clinical chemistry changes suggesting hepatotoxicity, decreased thymus weight, thymic atrophy, increased glycogen in liver, hemorrhage in mesenteric lymph nodes; F = decreased body weight gain (44%), anemia with extramedullary hematopoiesis in liver/ spleen and myeloidhyperplasia in bone marrow, clinical chemistry changes suggesting hepatotoxicity, decrease thymus weight, thymic atrophy and hyaline tubular change in kidney.
Ref: Federal Register: September 17, 2003 (Volume 68, Number 180)] Rules and Regulations. Trifloxysulfuron; Pesticide Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm

Bone (click on for all fluorinated pesticides)

-- In the rat teratology study, 300 and 1,000 mg/kg/day caused maternal toxicity consisting of reduced body weight and food consumption. Developmental toxicity was secondary to maternal toxicity and consisted of slightly reduced fetal body weights and an increase in minor skeletal anomalies and variations. The NOAELs for maternal and developmental toxicity were both 30 mg/kg/day...
Ref: Federal Register: March 21, 2003. Trifloxysulfuron-sodium; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food.
http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Mar21.03.htm

-- Prenatal developmental in rodents (rats). Maternal NOAEL: 300 mg/kg/day Maternal LOAEL: 1,000 mg/kg/day based on decreased food consumption during treatment, decreased body weight gain during post-treatment. Developmental NOAEL: 300 mg/kg/day Developmental LOAEL: 1,000 mg/kg/day based on slight decrease in fetal weight, increased skeletal anomalies, increased poor/absent skeletal ossification.
-- 90-Day oral toxicity in nonrodents (dogs). NOAEL: 19.8/19.6 mg/kg/day (M/F) LOAEL: 164.2/167.3 mg/kg/day (M/F): M = decreased body weight gain (20%), slight hematological effects, clinical chemistry changes suggesting hepatotoxicity, decreased thymus weight, thymic atrophy, increased glycogen in liver, hemorrhage in mesenteric lymph nodes; F = decreased body weight gain (44%), anemia with extramedullary hematopoiesis in liver/ spleen and myeloid hyperplasia in bone marrow, clinical chemistry changes suggesting hepatotoxicity, decrease thymus weight, thymic atrophy and hyaline tubular change in kidney.
Ref: Federal Register: September 17, 2003 (Volume 68, Number 180)] Rules and Regulations. Trifloxysulfuron; Pesticide Tolerance. Final Rule.

http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm

CNS (click on for all fluorinated pesticides)

• Note from FAN: We are including this under CNS even though no information was presented to clarify the lesions.

Acute dietary (general population) NOAEL = 600 mg/kg UF = 100. Acute RfD =6.0 mg/kg... Special FQPA SF = 1 aPAD = acute RfD/Special FQPA SF = 6.0 mg/kg. Acute Neurotoxicity Studies in Rats. LOAEL = 2,000 mg/kg based on decreased motor activity on day 1 and histopathological lesions in nervous system tissues of males and females.
Ref: Federal Register: September 17, 2003 (Volume 68, Number 180)] Rules and Regulations. Trifloxysulfuron; Pesticide Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm

Endocrine: Testicular (click on for all fluorinated pesticides)

-- The main hazards associated with repeat exposure to product are systemic effects (effects on liver, haematopoietic system and testes). No worker exposure data were available for trifloxysulfuron sodium or ENVOKE HERBICIDE. NOHSC used UK POEM to estimate mixer/loader and applicator exposure. The repeat dose risk assessment indicated that workers should wear elbow- length PVC gloves when preparing spray.
-- Dogs were given trifloxysulfuron at doses of 0, 50, 200 or 500 mg/kg bw/day in gelatin capsules for 28 days. There were no mortalities, changes in food consumption, clinical signs of toxicity or effects on body weight gain. A white material in the faeces of animals at 500 mg/kg bw/day was confirmed by analysis to be the test material. Red blood cell count, haematocrit, haemoglobin, platelet counts and clotting times, plasma bilirubin, protein and albumin were lower and globulin and chloride were higher in both sexes at 500 mg/kg bw/day. Plasma bilirubin was also lower in females at 200 mg/kg bw/day and plasma potassium and calcium were lower in males at 500 mg/kg bw/day. Liver weights were higher in both sexes at 200 and 500 mg/kg bw/day. Thymus weights were marginally lower with one of two males and one of two females at 500 mg/kg bw/day having slight cortical atrophy in the thymus. Testes weight was lower in one of the two males at 500 mg/kg bw/day along with markedly reduced spermatogenesis and some single cell necrosis of tubular cells. This male also had slight follicular hypertrophy in the thyroid. Spleen weights were higher in females at 500 mg/kg bw/day with lymphoid hyperplasia observed in the spleen of males at 200 and 500 mg/kg bw/day and females at all doses. Pneumonia was observed in dogs at 500 mg/kg bw/day.
Ref: August 2002 -
Evaluation of the new active Trifloxysulfuron-sodium in the product ENVOKE HERBICIDE. Public Release Summary. National Registration Authority for Agricultural and Veterinary Chemicals 2002 ISSN1443-1335.

http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Eval.02.pdf

-- In a 2-year chronic toxicity and carcinogenicity study, rats were fed diets containing trifloxysulfuron-sodium that resulted in average (sexes combined) daily test substance intakes of 0, 2.08, 22.0, 91.0 or 464 mg/kg/day... At terminal sacrifice, the testes to body weight ratio was increased by 19% in the 464 mg/kg/day group. Microscopical examination revealed a non-dose responsive increase in the incidence of kidney tubular atrophy in the two top dose groups of female rats, and an increase in Leydig cell hyperplasia in high dose males only. Both treatment-related lesions occurred late in age/ treatment, and were not seen in animals sacrificed in the initial year of the study... In conclusion, the MTD (maximum tolerance dose) was reached or exceeded at 464 mg/kg/day for the 2-year rat feeding study. The NOAEL in males was 82.6 mg/kg/day based on the increased incidence of Leydig cell hyperplasia, and 23.7 mg/kg/day in females based on the increased incidence of kidney tubular atrophy. There was no evidence of a carcinogenic effect after 2 years of treatment with trifloxysulfuron-sodium in rats.
Ref: Federal Register: March 21, 2003. Trifloxysulfuron-sodium; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food.
http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Mar21.03.htm

Endocrine: Thymus (click on for all fluorinated pesticides)

-- Short Term Studies. Trifloxysulfuron applied to the skin of rats at doses of 0, 10, 100 or 1000 mg/kg bw/day for 28 days did not result in any deaths, abnormal clinical signs, skin irritation, changes in food consumption, macroscopic changes or microscopic lesions attributable to treatment. Body weight gain was lower in females at 1000 mg/kg/day and haemoglobin and phosphate were slightly lower in males at 1000 mg/kg bw/day. Thymus weights were lower in males at 100 and 1000 mg/kg bw/day and in females at 1000 mg/kg bw/day.
-- Dogs were given trifloxysulfuron at doses of 0, 50, 200 or 500 mg/kg bw/day in gelatin capsules for 28 days. There were no mortalities, changes in food consumption, clinical signs of toxicity or effects on body weight gain. A white material in the faeces of animals at 500 mg/kg bw/day was confirmed by analysis to be the test material. Red blood cell count, haematocrit, haemoglobin, platelet counts and clotting times, plasma bilirubin, protein and albumin were lower and globulin and chloride were higher in both sexes at 500 mg/kg bw/day. Plasma bilirubin was also lower in females at 200 mg/kg bw/day and plasma potassium and calcium were lower in males at 500 mg/kg bw/day. Liver weights were higher in both sexes at 200 and 500 mg/kg bw/day. Thymus weights were marginally lower with one of two males and one of two females at 500 mg/kg bw/day having slight cortical atrophy in the thymus. Testes weight was lower in one of the two males at 500 mg/kg bw/day along with markedly reduced spermatogenesis and some single cell necrosis of tubular cells. This male also had slight follicular hypertrophy in the thyroid. Spleen weights were higher in females at 500 mg/kg bw/day with lymphoid hyperplasia observed in the spleen of males at 200 and 500 mg/kg bw/day and females at all doses. Pneumonia was observed in dogs at 500 mg/kg bw/day.
Ref: August 2002 -
Evaluation of the new active Trifloxysulfuron-sodium in the product ENVOKE HERBICIDE. Public Release Summary. National Registration Authority for Agricultural and Veterinary Chemicals 2002 ISSN1443-1335.

http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Eval.02.pdf

Heart (click on for all fluorinated pesticides)

Prenatal developmental in nonrodents (rabbit). Maternal NOAEL: 100 mg/kg/day Maternal LOAEL: 250 mg/kg/day based on increased mortality, increased vaginal/ anal bleeding. Developmental NOAEL: 50 mg/kg/day Developmental LOAEL: 100 mg/kg/day based on abnormally shaped heart (one fetus at 100 mg/kg/day and 3 fetuses from 2 litters at 250 mg/kg/day)... In historical control data provided by the registrant, there were no reported instances of abnormally shaped hearts.
Ref: Federal Register: September 17, 2003 (Volume 68, Number 180)] Rules and Regulations. Trifloxysulfuron; Pesticide Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm

Kidney (click on for all fluorinated pesticides)

-- In a 2-year chronic toxicity and carcinogenicity study, rats were fed diets containing trifloxysulfuron-sodium that resulted in average (sexes combined) daily test substance intakes of 0, 2.08, 22.0, 91.0 or 464 mg/kg/day... At terminal sacrifice, the testes to body weight ratio was increased by 19% in the 464 mg/kg/day group. Microscopical examination revealed a non-dose responsive increase in the incidence of kidney tubular atrophy in the two top dose groups of female rats, and an increase in Leydig cell hyperplasia in high dose males only. Both treatment-related lesions occurred late in age/ treatment, and were not seen in animals sacrificed in the initial year of the study... In conclusion, the MTD was reached or exceeded at 464 mg/kg/day for the 2-year rat feeding study. The NOAEL in males was 82.6 mg/kg/day based on the increased incidence of Leydig cell hyperplasia, and 23.7 mg/kg/day in females based on the increased incidence of kidney tubular atrophy. There was no evidence of a carcinogenic effect after 2 years of treatment with trifloxysulfuron-sodium in rats.
Ref: Federal Register: March 21, 2003. Trifloxysulfuron-sodium; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food.
http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Mar21.03.htm

Liver (click on for all fluorinated pesticides)

-- The main hazards associated with repeat exposure to product are systemic effects (effects on liver, haematopoietic system and testes). No worker exposure data were available for trifloxysulfuron sodium or ENVOKE HERBICIDE. NOHSC used UK POEM to estimate mixer/loader and applicator exposure. The repeat dose risk assessment indicated that workers should wear elbow- length PVC gloves when preparing spray.
Ref: August 2002 -
Evaluation of the new active Trifloxysulfuron-sodium in the product ENVOKE HERBICIDE. Public Release Summary. National Registration Authority for Agricultural and Veterinary Chemicals 2002 ISSN1443-1335.

http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Eval.02.pdf

-- Subchronic toxicity. Trifloxysulfuron-sodium technical was evaluated in a number of subchronic studies. In a 3-month rat feeding study the NOAEL was 65.7 mg/kg with hematologic and liver effects noted. In a 3-month mouse feeding study, the NOAEL was 67.9 mg/kg. Effects seen were adaptive liver effects. In a 3-month feeding study in dogs the NOAEL was 19.6 mg/kg and hematopoietic and liver effects were seen. In a 28-day dermal (rat) study, the NOAEL was 100 mg/kg. In this study only body weight effects were noted, and only occurred at 1,000 mg/kg.
Ref: Federal Register: March 21, 2003. Trifloxysulfuron-sodium; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food.
http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Mar21.03.htm

Lymph node (click on for all fluorinated pesticides)

870.3150 90-Day oral toxicity in nonrodents (dogs). NOAEL: 19.8/19.6 mg/kg/day (M/F) LOAEL: 164.2/167.3 mg/kg/day (M/F): M = decreased body weight gain (20%), slight hematological effects, clinical chemistry changes suggesting hepatotoxicity, decreased thymus weight, thymic atrophy, increased glycogen in liver, hemorrhage in mesenteric lymph nodes; F = decreased body weight gain (44%), anemia with extramedullary hematopoiesis in liver/ spleen and myeloidhyperplasia in bone marrow, clinical chemistry changes suggesting hepatotoxicity, decrease thymus weight, thymic atrophy and hyaline tubular change in kidney.
Ref: Federal Register: September 17, 2003 (Volume 68, Number 180)]. Trifloxysulfuron; Pesticide Tolerance. Final Rule.

http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm

Lung (click on for all fluorinated pesticides)

-- Dogs were given trifloxysulfuron at doses of 0, 50, 200 or 500 mg/kg bw/day in gelatin capsules for 28 days... Pneumonia was observed in dogs at 500 mg/kg bw/day.
Ref: August 2002 -
Evaluation of the new active Trifloxysulfuron-sodium in the product ENVOKE HERBICIDE. Public Release Summary. National Registration Authority for Agricultural and Veterinary Chemicals 2002 ISSN1443-1335.
http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Eval.02.pdf

Chronic toxicity dogs NOAEL: 51.1/45.3 mg/kg/day (M/F) LOAEL: 123/121 mg/kg/day (M/F): M = gray- white foci in lungs, fibrous thickening of lung pleura, equivocal decreased body weight gain; F = equivocal increased incidence and severity of chronic urinary bladder inflammation.
Ref: Federal Register: September 17, 2003 (Volume 68, Number 180)] Rules and Regulations. Trifloxysulfuron; Pesticide Tolerance. Final Rule.
http://www.fluorideaction.org/pesticides/trifloxysulfuron.fr.sept.03.htm

Spleen (click on for all fluorinated pesticides)

-- Dogs were given trifloxysulfuron at doses of 0, 50, 200 or 500 mg/kg bw/day in gelatin capsules for 28 days. There were no mortalities, changes in food consumption, clinical signs of toxicity or effects on body weight gain. A white material in the faeces of animals at 500 mg/kg bw/day was confirmed by analysis to be the test material. Red blood cell count, haematocrit, haemoglobin, platelet counts and clotting times, plasma bilirubin, protein and albumin were lower and globulin and chloride were higher in both sexes at 500 mg/kg bw/day. Plasma bilirubin was also lower in females at 200 mg/kg bw/day and plasma potassium and calcium were lower in males at 500 mg/kg bw/day. Liver weights were higher in both sexes at 200 and 500 mg/kg bw/day. Thymus weights were marginally lower with one of two males and one of two females at 500 mg/kg bw/day having slight cortical atrophy in the thymus. Testes weight was lower in one of the two males at 500 mg/kg bw/day along with markedly reduced spermatogenesis and some single cell necrosis of tubular cells. This male also had slight follicular hypertrophy in the thyroid. Spleen weights were higher in females at 500 mg/kg bw/day with lymphoid hyperplasia observed in the spleen of males at 200 and 500 mg/kg bw/day and females at all doses. Pneumonia was observed in dogs at 500 mg/kg bw/day.
Ref: August 2002 -
Evaluation of the new active Trifloxysulfuron-sodium in the product ENVOKE HERBICIDE. Public Release Summary. National Registration Authority for Agricultural and Veterinary Chemicals 2002 ISSN1443-1335.
http://www.fluoridealert.org/pesticides/Trifloxysulfuron-s.Eval.02.pdf

Environmental (click on for all fluorinated pesticides)

Potential Ground Water Contaminant.
Ref: PAN Pesticides Database - Chemicals for Triflusulfuron-methyl.

http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC34661

A  February 16, 2005, check at the Code of Federal Regulations for Trifloxysulfuron-sodium this herbicide is permitted in or on 49 food commodities in the United States. The following list identifies these crops for which EPA has set pesticide tolerances. 
[Code of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.591]
[Page 516-517]

TITLE 40--PROTECTION OF ENVIRONMENT

CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)

PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE CHEMICALS
IN FOOD--Table of Contents

Subpart C_Specific Tolerances

Sec. 180.591 Trifloxysulfuron; tolerances for residues.
(a) General. Tolerances are established for residues of the
herbicide trifloxysulfuron, N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]
carbonyl]-3-(2,2,2-trifluoroethoxy)-2-pyridinesulfonamide in or on the
following raw agricultural commodities.
Commodity Parts per Million CFR
Almond 0.02 180.591
Almond, hulls 0.01 180.591

Fruit, citrus, Group 10

This group includes 43 commodities - see Ref 1 below.

0.03 180.591
Cotton, undelinted seed 0.05 180.591
Cotton, gin byproducts 1.0 180.591
Sugarcane 0.01 180.591
Tomato 0.01 180.591
(b) Section 18 emergency exemptions. [Reserved]
(c) Tolerances with regional registrations. [Reserved]
(d) Indirect or inadvertent residues. [Reserved]

(Ref 1) Fruit, citrus, group 10. This group includes 43 commodities

calamondin • citron, citrus • citrus • citrus hybrids • citrus hybrids, dried pulp • citrus hybrids, juice • citrus hybrids, oil • citrus, dried pulp • citrus, juice • citrus, meal • citrus, molasses • citrus, oil • fruit • fruit, citrus • fruit, citrus, dried pulp • fruit, citrus, except mandarin • fruit, citrus, postharvest • grapefruit • grapefruit, dried pulp • grapefruit, juice • grapefruit, oil • kumquat • lemon • lemon, dried pulp • lemon, juice • lemon, oil • lime • lime, dried pulp • lime, juice • lime, oil • mandarin, satsuma • orange, sour • orange, sour, dried pulp • orange, sour, juice • orange, sour, oil • orange, sweet • orange, sweet, dried pulp • orange, sweet, juice • orange, sweet, oil • pummelo • tangelo • tangerine

 
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