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Return to Adverse
Effects
ACTIVITY: Herbicide
(sulfonylurea)
CAS Name: N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(trifluoromethyl)-2-pyridinesulfonamide
Structure:
| Adverse
Effects:
Bone
Kidney
Liver
Reproductive/Developmental |
Regulatory
Information
(only comprehensive for the US) |
| US
EPA Registered: |
Pending |
Registered
use in
(includes only a limited list of countries) |
Hungary,
Japan, New Zealand, Taiwan |
| Japan's
Maximum Residue Levels (MRLs) |
Grape,
Grapefruit, Lemon, Lime, Natsudaidai (whole), Orange, Other
Citrus fruits, Sugarcane, Unshu orange |
| Other
Information |
| Molecular
Formula: |
C13H12
F3 N5O5S |
| Entry
Year: |
1989 |
| Inventing
Company: |
ISK
Biosciences |
| Other
Names: |
Flazasulfuron
25 WG
Katana 25% WG
Shibagen
OK-1166
SL-160
Technical Flazasulfuron Herbicide
|
| Of
special interest: |
| PAN
Data |
| March
10, 2004. EU: Commission Directive
2004/30/EC of 10 March 2004 amending Council Directive 91/414/EEC
to include benzoic acid, flazasulfuron and pyraclostrobin as
active substances (Text with EEA relevance). Official Journal
L 077 , 13/03/2004 P. 0050 - 0053. |
2004
- Trial information. Control
of Broadleaf Weeds with Flazasulfuron in Texas. University
of Georgia Coop Ext Service.
Initiation Date: 5-27-2004. Planned Completion Date: 7-26-2004. |
| November
27, 2003. EU: Review
report for the active substance flazasulfuron. SANCO/ 3051/99/-Final.
List of uses supported by available data: Citrus, Grapes, Olives.
COMMISSION WORKING DOCUMENT - DOES NOT NECESSARILY REPRESENT
THE VIEWS OF THE COMMISSION SERVICES. |
| February
18, 2002 -
European Commission
decision to extend provisional authorisation granted
for new active substances which included flazasulfuron |
| October
2001 - Glossary
of Pesticide Chemicals, A listing
of pesticides subject to analysis of residues in foods and feeds
by the US Food and Drug Administration. |
| Federal
Register |
| Date
Published |
Docket
No. |
Details |
| Nov
10, 2004 |
OPP-2004-0353 |
ISK
Biosciences
Corp. Product
registration application for new
active ingredient not included
in any previously registered products.
1.
File Symbol: 71512-RR. Applicant: ISK Biosciences Corporation,
7470 Auburn Road, Suite A, Concord, OH 44077. Product
Name: Technical Flazasulfuron
Herbicide. Active ingredient:
Flazasulfuron at 96.9%. Proposed
classification/Use: None. For manufacturing use only.
2.
File Symbol: 71512-RE. Applicant: ISK Biosciences Corp. Product
Name: Flazasulfuron 25 WG.
Active ingredient: Flazasulfuron
at 25%. Proposed classification/Use: None. For
use as a selective herbicide on professionally managed turf. |
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http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12798760&dopt=Abstract
Ecotoxicol
Environ Saf. 2003 Jul;55(3):271-277.
Pigments
as biomarkers of exposure to the vineyard herbicide flazasulfuron
in freshwater algae.
Couderchet
M, Vernet G.
Laboratoire
d'Eco-Toxicologie, Unite de Recherches Vigne et Vin de Champagne
(URVVC), UPRES
EA 2069, Universite de Reims Champagne-Ardenne, BP 1039, F-51687
Cedex 02, Reims, France
Abstract:
Weed control in Champagne vineyards has long relied on the
use of diuron and substituted triazines; these
compounds are now being replaced by flazasulfuron,
a sulfonylurea that is used at a much lower dosage.
The vineyards of Champagne are planted on steep slopes and
runoff is important, and even though low doses of these
herbicides are used, they may present some potential risk
for freshwater ecosystems. Therefore, the effects of the sulfonylurea
herbicide, flazasulfuron (formulated
as Katana) was investigated on the unicellular green
alga Scenedesmus obliquus. The pigment content of the algal
suspensions was followed as a biomarker of exposure to the
herbicide. The results demonstrate that flazasulfuron induced
a reduction in chlorophyll content at concentrations of 10&mgr;g/L,
while the increase of pigment content in the culture was reduced
with the lowest concentration tested (0.1&mgr;g/L). Among
the three pigments tested, chlorophyll a appeared to be the
most sensitive biomarker. In the algal
medium, flazasulfuron was slowly degraded (DT(50) approximately
8 days) in a compound that was tentatively identified. The
toxicity of this herbicide for the algae was comparable to
that of older herbicides which are used at a much higher rate.
Therefore, we may speculate that even if flazasulfuron comes
into contact with freshwater ecosystems, its effects on algae
will be less deleterious than that of traditional herbicides.
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