Return to Flufenpyr-ethyl
Adverse Effects
ACTIVITY:
Herbicide (pyridazinone)
CAS Name
for
Flufenpyr:
[2-chloro-4-fluoro-5-[5-methyl-6-oxo-4-(trifluoromethyl)-1(6H)-pyridazinyl]phenoxy]acetic
acid
NOTES:
This compound is normally used as a salt or an ester, the identity
of which should be stated, e.g. flufenpyr-ethyl [188489-07-8].
Structure
for Flufenpyr:
Adverse
Effects:
Anemia
Blood
Endocrine: Thymus
Kidney
Liver |
Environmental
Effects:
As
of Dec 2003: no data available
|
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
108853 |
US Tolerances: |
180.595 |
Registered
use in
(includes only a limited list of countries)
|
US |
US
Maximum Residue Levels permitted
in food commodities
|
Corn,
Soybean, Sugarcane
On
September
19, 2003, US EPA established its first-time tolerance
for Flufenpyr-ethyl. |
Other
Information |
Manufacturers: |
Valent
Sumitomo |
Other
Names: |
S-3153;
ET-751 2.5% EC Herbicide;
ET-751 Technical |
Of
special interest: |
PAN
Data |
August,
2001 - IR-4:
New
Products/Transitional Solution List - This
list contains brief descriptions of numerous new pest control
materials that have been introduced over the last several years.
Additionally, it contains information on some "older"
crop protection chemicals that are believed to have room for
new uses. This List includes:
Flufenpyr-ethyl
|
2003
- US EPA 2003 work
plan for registration of 19 conventional pesticides; 6 of
the 19 are fluorinated. They are Butafenacil,
Flonicamid,
Flufenpyr-ethyl, Noviflumuron,
Quinoxyfen, Trifloxysulfuron |
Chemical
|
Pesticide
Type |
Uses
|
Registrant |
Comments |
Flufenpyr-ethyl |
Herbicide |
Corn,
Soybean, Sugarcane |
Valent |
USDA
vulnerable pest/crop |
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click here
to see full list of FR entries.
|
Published
Date |
Docket
Identification Number |
Details |
Sept
19, 2003
|
OPP-2003-0166
|
Valent
- Flufenpyr-ethyl
- Pesticide
tolerances. FINAL RULE.
-- No
tolerances have been previously established for the residues
and the combined residues of flufenpyr-ethyl, in or on raw agricultural
commodities.
-- C. Conditions
Confirmatory storage stability data for the metabolite S-3153
acid- 4-OH in field corn forage and stover and an
enforcement
method for measuring both parent and metabolite are required.
Tolerances
are established for residues of the herbicide, flufenpyr-ethyl;
acetic acid |
Commodity |
Parts
per million |
Corn,
field, grain
Soybean, seed
Sugarcane, cane |
0.01 |
Tolerances
are established for residues of the herbicide flufenpyr-ethyl;
acetic acid, and its metabolite,
S-3153 acid-4-OH; [2-chloro-4-hydroxy-5-[5-methyl-6- oxo-4-
(trifluoromethyl)-1-(6H)-pyridazinyl]-phenoxy]-acetic
acid, free and conjugated, in or on the following commodities: |
Corn,
field, forage
Corn, field, stover |
0.05 |
Some
excerpts from Table 1.--Subchronic, Chronic, and Other
Toxicity |
Study
type
[Guideline No.] |
Results |
Note:
no results were identified from rat studies |
90-Day oral toxicity rodents
(mouse) - [870.3100] |
NOAEL
= 395 mg/kg/day (M) LOAEL = 908 mg/kg/ day, based
on increased absolute and relative liver weights and increased
incidence of hepatic centrilobular vacuolation in male
mice |
28-Day
oral toxicity rodents
(mouse) - [870.3100] |
NOAEL
= 448/629 mg/kg/ day M/F LOAEL = 1,009/1,213 M/ F mg/kg/day,
based on increased incidence of
hepatic centrilobular vacuolation |
90-Day oral toxicity in non/ rodents
(dog) - [870.3150] |
NOAEL
= 300 mg/kg/day M/F LOAEL = 1,000 M/F mg/ kg/day, based
on decreased body weight gains, food consumption, and
food efficiency and increased incidence of vomiting |
Prenatal
developmental in nonrodents
(rabbit) - [870.3700] |
Maternal
NOAEL = 100 mg/kg/day LOAEL = 300 mg/kg/day, based
on increased maternal mortality, clinical signs, decreased
food consumption and necropsy findings Developmental
NOAEL = 1,000 mg/kg/ day LOAEL not identified |
Prenatal developmental in nonrodents
(rabbit) - [870.3700] |
Maternal
NOAEL = 100 mg/kg/day LOAEL = 200 mg/kg/day,
based on increased mortality Developmental NOAEL
= 1,000 mg/kg/ day HDT LOAEL not identified |
Carcinogenicity
rodents
(mouse) - [870.4200] |
NOAEL
= 39.9 - 43.7 mg/kg/day M/F LOAEL = 401.8 - 447.9 mg/kg/day
M/F, based on liver toxicity in
both sexes and mild anemia in males No evidence of carcinogenicity |
Some
excerpts from Table 2.-Summary of Toxicological Dose and
Endpoints for Flufenpyr-ethyl for Use in Human Health
Risk Assessment1 |
Note:
no results were identified from rat studies |
--Chronic
dietary (all populations)
-- Short-term inhalation (1-30 days)
--Intermediate-term inhalation (1-6 months)
-- Long-term inhalation (>6 months) |
Carcinogenicity
study - mice.
NOAEL = 40 mg/kg/day
LOAEL = 401.8 mg/kg/day based on
liver toxicity (hepatocyte necrosis) in both sexes and
mild anemia in males |
Short-term
Incidental oral (1-30 days) and (1-6 months) |
Developmental toxicity study - rabbit
NOAEL = 100 mg/kg/day LOAEL = 300 mg/kg/day, based
on clinical signs, decreased food consumption and necropsy
findings |
|
|