Flufenpyr-ethyl
CAS No. 188489-07-8
 
 

Return to Flufenpyr-ethyl Adverse Effects

ACTIVITY: Herbicide (pyridazinone)

CAS Name for Flufenpyr: [2-chloro-4-fluoro-5-[5-methyl-6-oxo-4-(trifluoromethyl)-1(6H)-pyridazinyl]phenoxy]acetic acid

NOTES: This compound is normally used as a salt or an ester, the identity of which should be stated, e.g. flufenpyr-ethyl [188489-07-8].

Structure for Flufenpyr:

Adverse Effects:

Anemia
Blood

Endocrine: Thymus
Kidney
Liver

Environmental Effects:
As of Dec 2003: no data available 
Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 108853 
US Tolerances: 180.595
Registered use in
(includes only a limited list of countries)

US 
US Maximum Residue Levels permitted in food commodities

Corn, Soybean, Sugarcane

On September 19, 2003, US EPA established its first-time tolerance for Flufenpyr-ethyl. 

Other Information
Manufacturers: Valent
Sumitomo
 
Other Names: S-3153;
ET-751 2.5% EC Herbicide;
ET-751 Technical
 
Of special interest:
PAN Data 
August, 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Flufenpyr-ethyl  

2003 - US EPA 2003 work plan for registration of 19 conventional pesticides; 6 of the 19 are fluorinated. They are Butafenacil, Flonicamid, Flufenpyr-ethyl, Noviflumuron, Quinoxyfen, Trifloxysulfuron 

Chemical

Pesticide Type

Uses

Registrant Comments
Flufenpyr-ethyl Herbicide Corn, Soybean, Sugarcane Valent USDA vulnerable pest/crop 

US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Published Date Docket Identification Number Details

Sept 19, 2003

 

 

 

 

 

 

 

 

 

 

 

 

 

 

OPP-2003-0166

 

 

 

 

 

 

 

 

 

Valent - Flufenpyr-ethyl - Pesticide tolerances. FINAL RULE.
--
No tolerances have been previously established for the residues and the combined residues of flufenpyr-ethyl, in or on raw agricultural commodities.
-- C. Conditions
Confirmatory storage stability data for the metabolite S-3153 acid- 4-OH in field corn forage and stover and an
enforcement method for measuring both parent and metabolite are required.

Tolerances are established for residues of the herbicide, flufenpyr-ethyl; acetic acid
Commodity Parts per million

Corn, field, grain
Soybean, seed
Sugarcane, cane

0.01
Tolerances are established for residues of the herbicide flufenpyr-ethyl; acetic acid, and its metabolite, S-3153 acid-4-OH; [2-chloro-4-hydroxy-5-[5-methyl-6- oxo-4- (trifluoromethyl)-1-(6H)-pyridazinyl]-phenoxy]-acetic acid, free and conjugated, in or on the following commodities:
Corn, field, forage
Corn, field, stover
0.05

Some excerpts from Table 1.--Subchronic, Chronic, and Other Toxicity
Study type
[Guideline No.]
Results
Note: no results were identified from rat studies
90-Day oral toxicity rodents
(mouse) - [870.3100]
NOAEL = 395 mg/kg/day (M) LOAEL = 908 mg/kg/ day, based on increased absolute and relative liver weights and increased incidence of hepatic centrilobular vacuolation in male mice
28-Day oral toxicity rodents
(mouse) - [870.3100]
NOAEL = 448/629 mg/kg/ day M/F LOAEL = 1,009/1,213 M/ F mg/kg/day, based on increased incidence of hepatic centrilobular vacuolation
90-Day oral toxicity in non/ rodents
(dog) - [870.3150]
NOAEL = 300 mg/kg/day M/F LOAEL = 1,000 M/F mg/ kg/day, based on decreased body weight gains, food consumption, and food efficiency and increased incidence of vomiting
Prenatal developmental in nonrodents
(rabbit) - [870.3700]
Maternal NOAEL = 100 mg/kg/day LOAEL = 300 mg/kg/day, based on increased maternal mortality, clinical signs, decreased food consumption and necropsy findings Developmental NOAEL = 1,000 mg/kg/ day LOAEL not identified
Prenatal developmental in nonrodents
(rabbit) - [870.3700]
Maternal NOAEL = 100 mg/kg/day LOAEL = 200 mg/kg/day, based on increased mortality Developmental NOAEL = 1,000 mg/kg/ day HDT LOAEL not identified
Carcinogenicity rodents
(mouse) - [870.4200]
NOAEL = 39.9 - 43.7 mg/kg/day M/F LOAEL = 401.8 - 447.9 mg/kg/day M/F, based on liver toxicity in both sexes and mild anemia in males No evidence of carcinogenicity

Some excerpts from Table 2.-Summary of Toxicological Dose and Endpoints for Flufenpyr-ethyl for Use in Human Health Risk Assessment1
Note: no results were identified from rat studies

--Chronic dietary (all populations)
-- Short-term inhalation (1-30 days)
--Intermediate-term inhalation (1-6 months)
-- Long-term inhalation (>6 months)

Carcinogenicity study - mice.
NOAEL = 40 mg/kg/day
LOAEL = 401.8 mg/kg/day based on liver toxicity (hepatocyte necrosis) in both sexes and mild anemia in males
Short-term Incidental oral (1-30 days) and (1-6 months) Developmental toxicity study - rabbit
NOAEL = 100 mg/kg/day LOAEL = 300 mg/kg/day, based on clinical signs, decreased food consumption and necropsy findings
 
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