Flumiclorac-pentyl
CAS No. 87546-18-7
 
 

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ACTIVITY: Herbicide (n-phenylphthalimide or dicarboximide)

CAS Name for Flumiclorac: [2-chloro-4-fluoro-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenoxy]acetic acid

Structure for Flumiclorac:

Adverse Effects:

Blood
Kidney
Liver
Phototoxic

Environmental Effects:

Highly toxic to Zooplankton

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 128724 
California Chemical Code 5090 
US Tolerances: CFR 180.477
CFR 186.3325
 
Registered use in
(includes only a limited list of countries)

US
Australia (pending as of June 2005)
US Maximum Residue Levels permitted in food commodities
Corn, field, forage
Corn, field, grain
Corn, field, stover
Soybean, hulls
Soybean, seed
Other Information
Entry Year: 1989 
Inventing Company: Sumitomo / Valent  
Manufacturers: Valent 
Pesticide imported from: Sumitomo Chemical Company, Ltd.
Tokyo, Japan
Other Names: Resource
S-23031
Stellar
Sumivere
V-23031
 
Of special interest:
PAN Data 
Material Safety Data Sheets & Labels
December 2, 2005 - Comments submitted to US EPA on new pesticide petition.
June 7, 2005 - AUSTRALIA: Notice published by the Australian Pesticides and Veterinary Medicines Authority (APVMA) soliciting comments relating to the approval of flumiclorac-pentyl, "a new active constituent for use in agricultural chemical products... Initially, it is to be used in Australia as a pre-harvest cotton defoliant... Comments must be received byAPVMA within 28 days of the date of this Gazette."
Ref: Commonwealth of Australia Gazette no. 6, 7 June 2005.

US EPA identifies Flumiclorac-pentyl in the category of a "Reduced-Risk Pesticide"

June 4, 2002 - A letter from Valent to US Congressional Committee on Ways & Means to support duty suspension on flumiclorac-pentyl. Includes details on amount Valent imports each year (In 1995 = 56,129 kgs.) and the Duty paid by Valent.
March 7, 2001 - Phototoxic Pesticides: US EPA Memo Requesting Phototoxicity Study Protocol for Light-Dependent Peroxidizing Herbicides
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. 

US Federal Register
Date Docket No. Details

March 8, 2006.

EPA-HQ-OPP-2005-0311 VALENT U.S.A. Corporation. Pesticide Tolerance. FINAL RULE.
Commodity
Parts per million
Corn, field, forage
0.01
Corn, field, grain
0.01
Corn, field, stover
0.01
Cotton gin by products
3.0
Cotton, undelinted seed
0.2
Soybean, hulls
0.02
Soybean, seed
0.01

90-Day oral toxicity-- nonrodents (dog) - increased clotting time in females

Reproduction and fertility effects (rat) - increased kidney weight in males and females and nephropathy in males; decreased body weight/body weight in F2 pups

Chronic toxicity-- dogs - decreased body weight gain in male; increased clotting time, increased globulin levels, and increased alpha-2 fraction of the serum protein electrophoresis in females

Cytogenetics - weak, positive response without activation

Nov 30 , 2005 OPP-2005-0311

VALENT U.S.A. Corporation. Pesticide petition PP 3F6767. Proposal to establish a tolerance for residues of the herbicide flumiclorac pentyl ester, pentyl [2-chloro-4-
fluoro-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenoxy]-
acetate in or on

Commodity Parts Per Million
cotton, undelinted seed 0.1 ppm
cotton, gin by products 2.0 ppm

The residue analytical method for enforcement purposes uses gas-liquid chromatography with a thermionic-specific detector. The enforcement method has been validated at an independent laboratory and by EPA. The method has been submitted to the Food and Drug Administration for publication in the Pesticide Analytical Manual, Vol. II (PAM II).

Note: see Comments submitted to US EPA on this pesticide petition.

Oct 19, 2005 OPP-2005-0229

This notice announces the availability of EPA's Tolerance Reassessment Decision (TRED) for the pesticide flumiclorac pentyl, and opens a public comment period on this document, related risk assessments, and other support documents. EPA has reviewed the low risk
pesticide flumiclorac pentyl through a modified, streamlined version of the public participation process that the Agency uses to involve the public in developing pesticide tolerance reassessment and reregistration decisions.

Flumiclorac pentyl is a post-emergence herbicide used on field corn, soybeans and non-crop areas, such as: industrial sites, airports, military installations, roadsides and associated rights-of-way, and other similar areas to control a selected group of broadleaf weeds, specifically morning-glory and velvet leaf. Although there are no labeled residential homeowner uses, there is potential risk for non-occupational exposure from other treated areas, such as golf courses, athletic fields, recreational areas, schools, apartment buildings, etc.

Documents made available for public comment:
Title of Report Docket No.
8-23-2005: Report of the Food Quality Protection Act (FQPA) Tolerance Assessment Progress and Risk Management Decision (TRED) - 7 pages OPP-2005-0229-0002 
6-28-2005: HED [Health Effects Division] Chapter of the TRED 
- 53 pages
OPP-2005-0229-0003 
6-24-2005: Flumiclorac Pentyl. Residue Chem for the TRED 
- 153 pages
OPP-2005-0229-0005 
6-24-2005: Flumiclorac Pentyl TRED Product Chem Considerations - 8 pages OPP-2005-0229-0006
3-17-2005: Flumiclorac pentyl Tier 1 Drinking Water Assessment  - 13 pages
OPP-2005-0229-0007
3-17-2005… Flumiclorac pentyl EFED Addendum No.1 to MRID#42169844   - 5 pages OPP-2005-0229-0008 
May 24, 2000 OPP-300756

Consolidation of Certain Food and Feed Additive Tolerance Regulations. FINAL RULE. This final rule transfers certain of the pesticide food and feed additive regulations that are now in 40 CFR parts 185 and 186 to part 180. EPA is consolidating these regulations because as a matter of law all of pesticide tolerances are now considered to be regulated under section 408 of the Federal Food, Drug, and Cosmetic Act as amended by the Food Quality Protection Act (Pub. L. 104-17) and they no longer need to be separate. EPA is also amending 40 CFR 180.1 by adding a definition for the term ``food commodity.'' 

Commodity Parts per million
Corn, field, grain 0.01
Corn, field, fodder 0.01
Corn, field, forage 0.01
Soybean, hulls 0.02
Soybean, seed 0.01
August 4, 1997 OPP-300523 Pesticides Subject to Tolerance Reassessment.
Nov 30, 1994 PP 3F4234 and
FAP 3H5682/R2091

VALENT - Pesticide Tolerances and Feed Additive Regulation.. - FINAL RULE. These rules establish tolerances for residues of the herbicide flumiclorac pentyl in or on the raw agricultural commodities field corn, grain; field corn, fodder; field corn, forage; and soybean, seed at 0.01 ppm, and in or on the feed additive commodity soybean hulls at 0.02 ppm.

1993  

VALENT - Pesticide Petition Tolerance for a feed additive regulation to permit residues of Resource Herbicide in or on soybean hulls at 0.02 ppm. [Note from EC: The FR is not online for 1993. This comes from a USDA bulletin on the PMEP website.


RESOURCE TM HERBICIDE
COMPOSITION/INFORMATION ON INGREDIENTS
Ref: Material Safety Data Sheet
Ingredient Name (CAS #)
[Chemical Name]
Weight PercentExposure Limit Ref.
FLUMICLORAC PENTYL ESTER*
(87546-18-7)
[Pentyl [2-chloro-4-fluoro-5-(1,3,4,5,6,7- hexahydro-1,3-dioxo-2H-isoindol-2- yl)phenoxy]acetate]
10.600 None -
INERT INGREDIENTS** 89.400 None -
*Active Ingredient
**Inert ingredients, which are maintained as trade secrets, are any substance other than an active ingredient contained in this product. Some of these may be hazardous, but their identity is withheld because they are considered trade secrets. The hazards associated with the inert ingredients are addressed in this document. Specific information on inert ingredients for the management of exposures, spills, or safety assessments can be obtained by a treating physician or nurse by calling 1-800-892-0099 at any time.


Stellar (R) Herbicide
COMPOSITION/INFORMATION ON INGREDIENTS
Ref: Material Safety Data Sheet
Ingredient Name (CAS #)
[Chemical Name]
Weight
Percent
Exposure Limit Ref.
Flumiclorac Pentyl (7.6%) and Lactofen (26.6%)* ( ) [-] 34.230 None -
INERT INGREDIENTS** 65.770 None -
*Active ingredient.
**Inert Ingredients, which are maintained as trade secrets, are any substance other than an active ingredient contained in this product. Some of these may be hazardous, but their identity is withheld because they are considered trade secrets. The hazards associated with the inert ingredients are addressed in this document. Specific information on inert ingredients for the management of exposures, spills, or safety assessments can be obtained by a treating physician or nurse by calling 1-800-892-0099 at any time.
     
 
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