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Adverse Effects
Abstracts
ACTIVITY:
Herbicide (phenylurea)
CAS Name:
N,N-dimethyl-N?-[3-(trifluoromethyl)phenyl]urea
Structure:
| Adverse
Effects:
Adverse
Effects:
Ataxia
Blood
Body Weight Decrease
Bone
Brain
Cancer: Possible Human Carcinogen:
Lung, Lymphocytic
lymphomas, (Liver?)
CNS
Endocrine: Pituitary
Endocrine: Testicular
Eye
Kidney
Leukemia
Liver
Lung
Reproductiv/Developmental
Spleen
Environmental |
Contamination
Incident:
July
2, 2004. Australia. Crash
kills crops. Herbicide scattered over field of canola. |
| Environmental
Effects:
Groundwater
pollutant. The
significant cancer risk contributors have been identified
as drinking water (direct and indirect, all sources), and
several rotational crops with wheat (flour), soybean (oil),
and rice (white) having the highest contributions.
Acute
risks to birds, mammals, and endangered species.
In
its March 2005 reassessment, EPA noted that several key studies
regarding risks to animals and fish have not been submitted
by the registrant, Makhteshim-Agan. |
Regulatory
Information
(only comprehensive for the US) |
| US
EPA Registered: |
Yes |
| US
EPA PC Code: |
035503 |
| California
Chemical Code |
166 |
| US
Tolerances: |
CFR
180.229
CFR 186.3350 |
| FDA
LMS Code: |
701 |
Registered
use in
(includes only a limited list of countries)
|
Australia,
India, US
Africa: Burkina
Faso, Cape Verde, Chad, Gambia, Guinea-Bissau, Mali, Mauritania,
Niger, Senegal, South Africa, Tanzania |
US
Maximum Residue Levels permitted
in food commodities
|
Cotton,
undelinted seed |
| Other
Information |
| Molecular
Formula: |
C10H11
F3 N2O |
| Entry
Year: |
1960
Marketed
in the US in 1960 (NTP,
page 1)
First registered in the US in May 1974 by Ciba |
| Inventing
Company: |
Ciba |
| Manufacturers: |
2005:
Agan Chemical Manufactures, Ltd.
The
US Agent for Agan is
Makhteshim-Agan of North America, Inc.
Previous
manufacturer : Novartis |
| Other
Names: |
Approved
for use in the US as of February 2005:
Meturon 4L, Meturon SODF, Cotoran@ 4L, Cotoran@ 80 DF, Fluometuron
SOW, Fluometuron 80DF, Fluometuron 4L, Fluometuron + MSMA, Drexel
CroakTMFluometuron + MSMA, Flo-Met 4L, Flo-Met 80DF, Cotoran@
+ MSMA with Surfactant, Cotoran@ SOW, Cotoran@ SOW, Cotoran@
4L, Cotoran@ DF, Cotoran@ Accu-Pak
See Herbicide
Products |
| Manufacture
site: |
CHINA:
Wenzhou Zhenan Medicine Factory, No. 26 Tutian Road, Yangfushan
Industry Zone, Wenzhou, Zhejiang 325003
ISRAEL: Agan Chemical, Ashdod
SWITZERLAND: formerly: Novartis,
Monthey
SWITZERLAND:
As of April 2003: Syngenta Crop Protection Monthey AG, Monthey
FRANCE: Rhone Poulenc, Le Pont
de Claix
AUSTRIA: Nufarm, Linz
ITALY: Industria Prodotti Chemici,
Novate Milanese
HUNGARY: EMV North-Hungarian
Chemical Works Co., Sajobabony |
| Of
special interest: |
| PAN
Data |
| Material
Safety Data Sheets & Labels |
2005
- Schedule for Reregistration & Tolerance Reassessment (RED)
is expected to be September 2005. Contact at EPA: Kylie Rothwell
(703) 308-8055; rothwell.kylie@epa.gov . According to EPA:
Through the pesticide reregistration and tolerance reassessment
programs, EPA is assessing risks and making risk management
decisions for older pesticides. These decisions are summarized
in documents known as REDs, IREDs, and TREDs. By making decisions
according to the schedule below, EPA will meet its statutory
deadlines for completing reregistration and tolerance reassessment.
Some of the decision dates presented in the schedule may change
due to the dynamic nature of the review process. Any pesticide
decisions that are not completed during the current fiscal year
will be rescheduled for the following year. EPA is committed
to meeting its reregistration and tolerance reassessment deadlines.
http://www.epa.gov/pesticides/reregistration/decision_schedule.htm
|
July
2, 2004. Crash
kills crops. Herbicide scattered over field of canola.
By Sam Edmund, regional reporter. Herald
Sun Melbourne (Australia). |
| TOXNET
profile from Hazardous Substances Data Bank |
| 1994
Pesticide Information Profile. EXTOXNET. |
| Abstracts |
| 1989
-
Summary of Toxicology
Data. California Department of Food
and Agriculure, Medical Toxicology Branch. |
| 1983
- Summary
of Data Reported and Evaluation -
International Agency for Research on Cancer |
| 1980
- National
Toxicology Program (NTP) Bioassay |
| US
Map of Pesticide use - 1992 - 1995 |
| 1990-1993
-
Cotton
pesticide usage in the US, 1990-1993 - USGS.
Trifluralin (# 2); Fluometuron (#3); Norflurazon (# 9) |
| See 3-(Trifluoromethyl)phenyl
urea,
a breakdown product |
| Occurrence
of Cotton Pesticides in Surface Water
- The major herbicides and their metabolites
that have been detected in surface water of the Mississippi
Embayment. The most-detected compound was fluometuron (see
table). The demethyl metabolites, demethylfluo-meturon and
demethylnorflurazon, were also commonly detected. |
| February
2000 - Hungary's
Pesticide Industry produces the fluorinated pesticides:
Benefin (BENFLURALIN); Flufenzin; Fluometuron;
Trifluralin. Hungary's pesticide industry includes partnerships
with DuPont, Rhone Poulenc, and the American CEDAR group. Hungary's
Ministry of Economic Affairs. |
| 2000
Toxic Release Inventory: Brief Summary. |
| See also: 3-Trifluoromethyl
aniline - used as an intermediate in the production of Fluometuron |
| Herbicide
Products - partial list |
EPA DOCUMENTS.
The following documents were made available in the Federal Register
docket:
0024-0029:
January
31, 2007
all the rest: April
6, 2005 |
| Docket
No. |
Title |
Date |
| EPA-HQ-OPP-2004-0372-0024 |
Revised
drinking water assessment and EFED’s Response to Exponent,
Inc. “SCI-GROW Modeling for Fluometuron and Its Primary
Metabolite, Desmethyl Fluometuron; and NAWQA Monitoring Data
on Fluometuron
- 18 pages |
Sept 27, 2005 |
| EPA-HQ-OPP-2004-0372-0025 |
Impacts
Assessment for Fluometuron
- 20 pages |
Sept 26, 2005 |
| EPA-HQ-OPP-2004-0372-0026 |
Refined
Fluometuron Percent Crop Treated and Percentage of National
Soybean, Corn, and Wheat Crops Rotated with Fluometuron-Treated
Cotton (62 pages)
- 62 pages |
Aug 9, 2005 |
| EPA-HQ-OPP-2004-0372-0027 |
Addendum
to Refined Fluometuron Percent Crop Treated
- 17 pages |
Sept 21, 2005 |
| EPA-HQ-OPP-2004-0372-0028 |
Usage
report in Support of Reregistration for the herbicide Fluometuron
|
Sept 14, 2005 |
| EPA-HQ-OPP-2004-0372-0029 |
Fluometuron:
Revised acute, chronic, and cancer dietary exposure assessments
for the Reregistration Eligibility Decision (RED) document
- 41 pages |
Sept 27, 2005 |
| OPP-2004-0372-0002 |
Overview
of Fluometuron Risk Assessment
- 16 pages |
March 30,
2005 |
| OPP-2004-0372-0003 |
Reader's
Guide to Fluometuron
- 3 pages |
March 29,
2005 |
| OPP-2004-0372-0004 |
Fluometuron
Use Closure Memorandum.
- 2 pages |
July 9,
2004 |
| OPP-2004-0372-0005 |
Table
1. Maximum Fluometuron Use Rates and Management Practices
by Crop Based on Current Labels
- 2 pages |
April 6,
2004 |
| OPP-2004-0372-0006 |
Table
A2. Food/Feed Use Patterns Summary for Fluometuron
- 4 pages |
April 6,
2004 |
| OPP-2004-0372-0007 |
Screening
Level Estimates of Agricultural Uses of Fluometuron (SLUA)
- 2 pages
|
March 16,
2004 |
| OPP-2004-0372-0008 |
Fluometuron:
Revised HED Risk Assessment for Phase III of the Reregistration
Eligibility Decision
- 66 pages
|
Feb 1,
2005 |
| OPP-2004-0372-0009 |
Revised
Environmental Fate and Ecological Risk Assessment of Fluometuron
- 224 pages
|
Feb 22,
2005 |
| OPP-2004-0372-0010 |
Fluometuron
Drinking Water Assessment for the Human Effects Division (HED)
Reregistration Eligibility Decision Document
- 28 pages
|
Dec 3,
2004 |
| OPP-2004-0372-0011 |
Phase
2 Response to Error Comments for Fluometuron RED (HED Risk Assessment)
- 3 pages
|
Feb 1,
2005 |
| OPP-2004-0372-0012 |
Makhteshim's
Review of the Health Effects Division Fluometuron Draft Science
Chapter
- 2 pages
|
Jan 13,
2004 |
| OPP-2004-0372-0013 |
Makhteshim's
Review of the Fluometuron Environmental Fate and Effects Science
Chapter - 4 pages
|
Dec 2,
2004 |
| OPP-2004-0372-0014 |
EFED
response to Registrant's 30 day Error Correction Comments on
Fluometuron RED
- 6 pages
|
Feb 22,
2005 |
| OPP-2004-0372-0015 |
Cotton
Council Meeting notes
- 1 page
|
Aug 21,
2004 |
| OPP-2004-0372-0016 |
Fluometuron.
Acute, Chronic, and Cancer Dietary Exposure Assessments for
the Reregistration Eligibility Decision (RED) Document
- 34 pages
|
Nov 30,
2004 |
| OPP-2004-0372-0017 |
Fluometuron:
Occupational Exposure Assessment for the Reregistration Eligibility
Decision Document
- 38 pages
|
Dec 7,
2004 |
| OPP-2004-0372-0018 |
Fluometuron.
Summary of Product Chemistry for the Reregistration Eligibility
Decision (RED) Document.
- 12 pages
|
Nov 3,
2004 |
| OPP-2004-0372-0019 |
Fluometuron.
Summary of Analytical Chemistry and Residue Data for the Reregistration
Eligibility Decision (RED) Document
- 38 pages |
Nov 30,
2004 |
| OPP-2004-0372-0020 |
Fluometuron
Request for Information and Mitigation Proposals Phase 3 of
4-Phase Process
- 3 pages
|
March 30,
2005 |
Pesticide
use rates
estimated from the past 10 years indicate that the fluometuron
use rates are dropping considerably. This reduction in use
of fluometuron is likely due to available glyphosate resistant
cotton (Roundup Ready@).
Pesticide use rates compiled by the National Center for
Food and Agricultural Policy from pesticide use information
from 1990-1993 and 1995 indicated
a total of 4,500.857 pounds of fluometuron use in the U.S.
A more recent screening level estimate conducted by the
EPA for the agricultural uses of fluometuron
from 1998 to 2002 indicate 2.400.000
pounds with a 20% average percent crop treated on cotton
in the U.S.
Additionally, the registrant indicated that by their records,
the annual usage of fluometuron has dropped dramatically
in the last 4 years from approximately
3.7 million pounds in 2000 to approximately 1 million pounds
in 2003. (Page 2)
Ref.
February 1, 2005. US EPA: Fluometuron: Revised HED Risk
Assessment for Phase III of the Reregistration Eligibility
Decision. Docket Identification Number: OPP-2004-0372-0008.
http://www.fluorideaction.org/pesticides/fluometuron.opp-2004-0372-0008.pdf
Twelve
of the 26 most widely used pesticides in the U.S. are classified
as possible or probable carcinogens by the EPA based on
studies of laboratory animals,
with an annual use that totals 380 million pounds. (atrazine
(C=possible), metolachlor (C), metarn sodium (B2=probable),
dichloropropene (B2), cyanazine (C), pendimethalin (C),
trifluralin (C), acetochlor (B2), chlorothalonil (likely),
mancozeb (B2), fluometuron
(C), and parathion (C)...
[Journal of Pesticide Reform, Summer 1999, at 5]
Ref:
Testimony
of the Maine Organic Farmers and Gardeners Association
in support of L.D. 1540: "An Act to
Ensure that the State Board of Pesticides Control has Sufficient
Resources to Provide Accurate Information About the Use
of Pesticides in the State"
--
Note from FAN: Trifluralin, cited above, is another fluorinated
pesticide.
|
US
Federal Register
••
Note: Due to length, the following is a partial list. Click
here to see full list of FR entries.
|
| Date
Published |
Docket
Identification Number |
Details |
| January 31, 2007 |
EPA-HQ-OPP-2004-0372 |
Fluometuron
Reregistration Eligibility Decision. This notice announces
the availability of EPA's Reregistration Eligibility Decision
(RED) for the pesticide fluometuron. The Agency's risk assessments
and other related documents also are available in the fluometuron
Docket. Fluometuron is a phenylurea herbicide that is used
only on cotton. "Opportunities for public comment were
offered at the initial docket opening in April 2005 and as
this decision was being developed. Further, issues related
to fluometuron were resolved through consultations with stakeholders.
The Agency therefore is issuing
the fluometuron RED without a comment period."
| Docket
No. |
Title |
Date |
| EPA-HQ-OPP-2004-0372-0024 |
Revised
drinking water assessment and EFED’s Response to
Exponent, Inc. “SCI-GROW Modeling for Fluometuron
and Its Primary Metabolite, Desmethyl Fluometuron; and
NAWQA Monitoring Data on Fluometuron
- 18 pages |
Sept 27, 2005 |
| EPA-HQ-OPP-2004-0372-0025 |
Impacts
Assessment for Fluometuron
- 20 pages |
Sept 26, 2005 |
| EPA-HQ-OPP-2004-0372-0026 |
Refined
Fluometuron Percent Crop Treated and Percentage of
National Soybean, Corn, and Wheat Crops Rotated with Fluometuron-Treated
Cotton (62 pages)
- 62 pages |
Aug 9, 2005 |
| EPA-HQ-OPP-2004-0372-0027 |
Addendum
to Refined Fluometuron Percent Crop Treated
- 17 pages |
Sept 21, 2005 |
| EPA-HQ-OPP-2004-0372-0028 |
Usage
report in Support of Reregistration for the herbicide
Fluometuron |
Sept 14, 2005 |
| EPA-HQ-OPP-2004-0372-0029 |
Fluometuron:
Revised acute, chronic, and cancer dietary exposure assessments
for the Reregistration Eligibility Decision (RED) document
- 41 pages |
Sept 27, 2005 |
|
| August
3, 2005 |
OPP-2005-0201 |
Cancellation
of Pesticides for Non-payment of Year 2005 Registration Maintenance
Fees.
|
Section 3 registrations canceled for non-payment of
the 2005
maintenance fee are shown in the following table 2:
Table
2.--Section 3 Registrations Canceled for Non-Payment
of
Maintenance Fee |
|
Registration no. |
Product
Name |
| 066222-00031 |
Cotoran
80w Herbicide |
|
|
