Hydramethylnon
CAS No. 67485-29-4
US Federal Register
 
 

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Adverse Effects
Abstracts

ACTIVITY: Insecticide (unclassified)

CAS Name: tetrahydro-5,5-dimethyl-2(1H)-pyrimidinone [3-[4-(trifluoromethyl)phenyl]-1-[2-[4-
(trifluoromethyl)phenyl]ethenyl]-2-propenylidene]hydrazone

Structure:

US Federal Register

Published date Docket Identification Number Details
August 1, 2007 EPA-HQ-OPP-2004-0154

Proposal to Increase tolerances. Hydramethylnon (Pyrimidinone). EPA is increasing the following commodity tolerances in 40 CFR 180.395(a):

``grass (pasture and rangeland)'' from 0.05 ppm to 2.0 ppm

and revising the terminology to ``grass, forage'' and ``grass, hay;'' based on available field trial data which show residues of hydramethylnon above the current tolerance level and label amendments which reflect parameters of use patterns for which field trials are available; (i.e., reflect a 0 day post harvest interval) since the Agency no longer allows a PHI (post harvest interval) restriction on grass. The tolerance for ``grass hay (pasture and rangeland)'' was recommended to be increased from 0.05 ppm to 0.1 ppm, based on available field trial data previously discussed and label amendments which reflect a 0 day post harvest interval. However, because the terminology should be revised to ``grass, hay,'' that tolerance at 0.1 ppm is no longer needed since it would be a duplicate covered by the proposed tolerance at 2.0 ppm. Therefore, EPA is removing the tolerance in 40 CFR 180.395(a) for grass hay (pasture and rangeland).
After the hydramethylnon RED was completed in 1998, a permanent tolerance was established in 40 CFR 180.395(a) on pineapple (68 FR 48302, August 13, 2003)(FRL-7319-5). Since the proposal of August 4, 2004 (69 FR 47051), the time-limited tolerance for hydramethylnon residues on pineapple in 40 CFR 180.395(b), for section 18 emergency exemptions, expired on June 30, 2005. The Agency did not propose in a notice for comment to remove the text and table with the expired tolerance and reserve 40 CFR 180.395(b). However, section 553(b)(3)(B) of the Administrative Procedure Act provides that notice and comment is not necessary ``when the agency for good cause finds (and incorporates the finding and a brief statement of reasons therefore in the rules issued) that notice and public procedure thereon are impracticable, unnecessary, or contrary to the public interest.'' Consequently, for good cause, EPA is removing the text and table from 40 CFR 180.395(b) and reserving that section for emergency exemptions in this document. The reason for taking this action is because such action has no practical impact on the use of or exposure to the pesticide active ingredient, hydramethylnon, since the sole time-limited tolerance in 40 CFR 180.395(b) had expired and, as it no longer needs to be codified in that section, should be removed for the sake of clarity.
•• Document made available with this notice:

Nov 14, 1996: Pyrimidinone. Case 2585. Chemical 118401. Product and Residue Chemistry Chapters for the Reregistration Eligibility Decision (RED). From K. Dockter, USEPA Chemistry Branch II to Jane Smith, USEPA Risk Characterization & Analysis Branch. August 1, 2007, Docket EPA-HQ-OPP-2004-0154-0013.

August 3, 2005 OPP-2005-0201

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Section 24(c) Registrations canceled for non-payment of the 2005
maintenance fee are shown in the following Table 1:

Table 1.--Section 24(c) Registrations Canceled for Non-Payment of Maintenance Fee

SLN no. Product Name
000241 TX-01-0016 Amdro Fire Ant Insecticide
Oct 27, 2004 OPP-2004-0338 Cancellation of Pesticides for Non-payment of Year 2004 Registration Maintenance Fees.
Table 1.--Section 24(c) Registrations Canceled for Non-Payment of
Maintenance Fee
Name of Pesticide Product Name Registrant SLN No.
Hydramethylnon

Amdro Fire Ant Insecticide

BASF Corporation 000241 HI-02-0003
Hydramethylnon Amdro Fire Ant Insecticide BASF Corporation 000241 HI-02-0009.
August 4, 2004 OPP-
2004-0154

Tolerances increased and terminology modified. EPA is proposing to increase the tolerance in 40 CFR 180.395(a) on ``grass (pasture and rangeland)''
from 0.05 to 2.0 ppm and revise the terminology to ``grass, forage''
and ``grass, hay;'' based on available field trial data which show
residues of hydramethylnon above the current tolerance level and label
amendments which reflect parameters of use patterns for which field
trials are available; i.e., reflect a zero day post harvest interval
since that the Agency no longer allows a PHI restriction on grass.

Section 180.395 is amended by revising the table in paragraph (a) to read as follows:
Commodity
Parts per million
Grass, forage
2.0
Grass, hay
2.0
Pineapple
0.05
Nov 26, 2003 OPP-2003-0358 Pesticide Emergency Exemption. A ``specific exemption'' authorizes use of a pesticide against specific pests on a limited acreage in a particular State.
-- Hawaii Department of Agriculture. Specific. EPA authorized the use of hydramethylnon on pineapple to control big-headed and Argentine ants; June 6, 2003 to June 24, 2004.
Aug 13, 2003 OPP-2003-0251 BASF. Pesticide Tolerance for Pineapple at 0.05 ppm. FINAL RULE.
The US EPA Cancer Peer Review Committee classified hydramethylnon as a Group C-possible human carcinogen, and recommended that, for the purpose of risk characterization, the Reference Dose approach should be used for quantification of human risk. This classification was based upon statistically significant increases in lung adenomas and combined lung adenomas/carcinomas in female mice.
Subchronic, Chronic, and Other Toxicity (from Table 1.)
Study Type Results
Rat -
Subchronic Feeding
NOAEL = 2.5 mg/kg/ - Rat day LOAEL = 5.0 mg/kg/ day - decreased testicular weights (34%), and testicular atrophy.
Dog - Subchronic Gavage NOAEL = 3 mg/kg/ day - LDT; decreased food consumption (11%/ 20%, males/ females) and body weight gain (11%/ 9%, males/ females). LOAEL = not defined Lethal Dose = 6 mg/kg/day - decreased food consumption and body weight gain, SGPT, cachexia, wasting of muscle and subcutaneous fat, testicular atrophy, and death.
Rabbit -
21-Day Dermal
NOAEL = 250 mg/kg/day (HDT) Food consumption was depressed as much as 38% and 45% in the high- dose males and females, compared to controls. The high-dose males and females weighed as much as 8% and 9% less than the controls. The platelet count in the high-dose females at termination was 54% less than controls, but was not considered adverse because it is a common finding following skin abrasion.
Rat - Developmental Toxicity Maternal NOEL = 3 mg/kg/day Maternal NOAEL = 10 mg/kg/day - 8% decrease in body weight and yellowish discoloration of the fat. Maternal LOAEL = 30 mg/kg/day - 16% decrease in body weight; increased incidence of nasal mucus, alopecia, soft stools, staining of the anogenital fur, yellowish discoloration of the fat, and small thymus. Developmental NOEL = 10 mg/kg/ day Developmental LOAEL = 30 mg/kg/ day - decreased mean fetal weights and increased incidence of rudimentary structures and incompletely ossified supraoccipitals. At 30 mg/kg/day, a 16% decrease in maternal body weight, increased incidence of clinical signs (nasal mucus, alopecia, soft stool, staining of anogenital fur), yellowish discoloration of the fat, and small thymus were observed.
Rabbit - Developmental Toxicity ... Developmental NOAEL = 5 mg/kg/ day - decreased fetal weight (8%). Developmental LOAEL = 10 mg/kg/ day - abortions, decreased fetal weight (16%).
Rat -
2-Generation Reproductive Toxicity
Reproductive/ Systemic NOAEL = 25 ppm (1.66/2.01 mg/kg/day, male/ female) Reproductive/ Systemic LOAEL = 50 ppm (3.32 / 4.13 mg/kg/day, male/female) (degeneration of the germinal epithelium (1/29) and aspermia (1/ 29)
Mouse -
Carcinogenicity Feeding (18 months)
NOAEL = 25 ppm (3.57 mg/kg/day) in males NOAEL = not defined in females. LOAEL = 50 ppm (6.93 mg/kg/day) in males (testicular lesions) LOAEL = 25 ppm (4.45 mg/kg/day) in females (LDT; combined lung adenomas and carcinomas) The high-dose females were sacrificed after 5 weeks due to high mortality.
Rat -
Chronic Feeding Toxicity/ Carcinogenicity
NOAEL = 50 ppm (2.4 mg/kg/day in males, 3.0 mg/kg/ day in females) LOAEL = 100 ppm (4.9 mg/kg/day in males, 6.2 mg/kg/ day in females) (small, soft testes, decreased testicular weights, and testicular atrophy in males; decreased body weight gain in females)

Conditions The following studies are required to further characterize the environmental effects of hydramethylnon:
-- Estuarine/marine fish LC
50 (72-1),
-- Estuarine/marine invertebrate EC50 (72-2), and
-- Sediment Toxicity Testing (Harmonized guidelines 850.1735 and 850.1740).

In addition, the following studies are required for any future expansion of hydramethylnon uses:
-- Aquatic Photodegradation (161- 2),
-- Aerobic Aquatic Metabolism (162-4), and
-- Terrestrial Field Dissipation (164-1).
June 25, 2003 OPP-2003-0179 Extension of tolerances for Emergency Exemptions. FINAL RULE. EPA has authorized under FIFRA section 18 the use of hydramethylnon on pineapple for control of big-headed and Argentine ants in Hawaii. This regulation extends a time-limited tolerance for residues of the insecticide hydramethylnon; in or on pineapple at 0.05 ppm for an additional 2-year period. This tolerance will expire and is revoked on June 30, 2005. A time-limited tolerance was originally published in the Federal Register of March 4, 1998 (63 FR 10537) (FR -5767-1).
Aug 7, 2002 OPP-2002-0164

Emergency Exemptions for pesticide use.

  • Hawaii Department of Agriculture - Specific: EPA authorized the use of hydramethylnon on pineapple to control big-headed and Argentine ants; May 31, 2002 to May 31, 2003.
Nov 14, 2001 OPP-181082 Pesticide Emergency Exemptions. In Hawaii EPA authorized use on pineapples to control big-headed and Argentine ants; May 15, 2001 to May 15, 2002.
May 24, 2001 OPP-301125 Extension of Tolerances for Emergency Exemptions. FINAL RULE. EPA has authorized under FIFRA section 18 the use of hydramethynon on pineapple for control of big-headed and Argentine ants in Hawaii. This regulation extends a time-limited tolerance for residues of the insecticide in or on pineapple at 0.05 ppm for an additional 2-year, 1-month period. This tolerance will expire and is revoked on June 30, 2003.
Oct 6, 1999 PF-835

AMERICAN CYANAMID - Pesticide Tolerance Petition for residues of in or on the raw agricultural commodity [pineapples] at 0.05 ppm.

July 14, 1999 na
  • Requests to voluntarily cancel FIVE pesticide product registrations.
  • American Cyanamid. Amdro Insecticide Roach Control Stations. EPA Reg. No. 000241--00293
  • American Cyanamid. Amdro Ant Control Stations. EPA Reg. No. 000241--00304
  • American Cyanamid. Amdro Insecticide Pharaoh Ant Control PCO Stations. EPA Reg. No. 000241--00320
  • Combat Insect Control Systems. Combat Ant Killer Granular Bait 0.65%. EPA Reg. No. 064240--00028
  • Maxforce Insect Control Systems. Maxforce Ant Killer Granular Bait 0.65%. EPA Reg. No. 064248--00007
March 10, 1999 OPP-34179 Availability of Reregistration Eligibility Decision (RED) Document for Comment.
Nov 25, 1998 OPP-300752 Extension of Tolerance for Emergency Exemptions. - FINAL RULE. This rule extends a time-limited tolerance for residues of the insecticide hydramethylnon in or on pineapples at 0.05 ppm for an additional one and one-half-year period, to May 30, 2001.
August 14, 1998 PF-824

AMERICAN CYANAMID - Pesticide Tolerance Petition; for residues of in or on the raw agricultural commodity pineapples at 0.05 ppm.

March 4, 1998 OPP-300606 Pesticide Tolerances for Emergency Exemptions. - FINAL RULE. This regulation establishes a time-limited tolerance for residues of hydramethylnon in or on pineapple at 0.05 ppm. The tolerance will expire and is revoked on January 31, 1999.
August 4, 1997 OPP-300523 Pesticides Subject to Tolerance Reassessment.
Jan 12, 1994 OPPTS-400082 EPA's proposal to add 41 fluorine and organofluorine chemicals to the Toxics Release Inventory (TRI). See excerpt in top box above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm
 
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