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Adverse Effects
Abstracts
NTIS
Reports
ACTIVITY: Former
Insecticide (Organophosphate)
Structure:
Diisopropyl
fluorophosphate (DFP) is an organophosphate compound used
as an insecticide, a substrate for the production of organophosphate
military "nerve" gases and formerly as a topical miotic
medication in ophthalmology.
DFP
has been used as an experimental agent in neuroscience because
of its ability to inhibit cholinesterase and cause delayed
peripheral neuropathy. It has been also used as a miotic
agent in the treatment of glaucoma. Although DFP has caused
experimental distal anoxopathy, no cases of peripheral neuropathy
have been reported in patients treated with this agent for
glaucoma.
For
Diisopropyl Fluorophosphate (USEPA/OPP PC Code: 356100)
Not registered for current use in
the U.S.
Insecticide
(former use)
[Hawley, G.G. The Condensed Chemical Dictionary. 10th ed.
New York: Van Nostrand Reinhold Co., 1981. 360]
Ref:
TOXNET Hazardous Substances Data Base for DIISOPROPYL FLUOROPHOSPHATE.
http://www.fluoridealert.org/pesticides/Isofluorphate-TOXNET.htm
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