Isoxaflutole
CAS No. 141112-29-0
 
 

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Adverse Effects
Abstracts

ACTIVITY: Herbicide (cyclopropylisoxazole)

CAS Name: (5-cyclopropyl-4-isoxazolyl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]methanone

Structure:

Adverse Effects:

Amyloidosis - Systemic
Blood

Body Weight Decrease

Bone
Cancer: Probable Human Carcinogen - LIVER, THYROID
Cholesterol
Endocrine: Pituitary - disruption in the thyroid-pituitary hormonal feedback mechanisms
Endocrine: Thyroid
Eye
Liver
Lymph node
Sciatic nerve

Environmental Effects:

Very Phytotoxic

Expected to Persist and Accumulate in surface and groundwater

Highly toxic to Mysid shrimp

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 123000 
US Tolerances: CFR 180.537 
FDA LMS Code: B15 
Registered use in
(includes only a limited list of countries)

Australia, Canada, Germany, Hungary, Netherlands, Portugal, US
Africa: Burkina Faso, Cameroon, Cape Verde, Chad, Gambia, Guinea-Bissau, Mali, Mauritania, Niger, Senegal, South Africa

US Maximum Residue Levels permitted in food commodities

US and Canada:
Cattle, Corn, Egg, Goat, Hog,
Horse, Milk, Poultry, Sheep

US - permitted in or on 28 food commodities

US - As of 2003, Wisconsin, Minnesota, and Michigan have not agreed to allow use of isoxaflutole due to concerns of "possible water contamination and effects on non-target plants, including vegetable crops."

Other Information
Molecular Formula: C15H12 F3 NO4S  
Entry Year: 1993 
Inventing Company: Rhone-Poulenc  
Manufacturers: Bayer CropScience,
Rhone-Poulenc
 
Other Names: Balance
Balance WDG
Epic
Merlin
EXP-30953
RP-201772
264-EUP-99
264-EUP-110
264-EUP-123
264-EUP-129
 
Of special interest:
PAN BAD ACTOR - Carcinogen 
April 2003 - Review report for the active substance isoxaflutole. Isoxaflutole Sanco/3136/99-Final. 7 April 2003. Finalised in the Standing Committee on the Food Chain and Animal Health at its meeting on 15 April 2003 in view of the inclusion of isoxaflutole in Annex I of Directive 91/414/EEC. 
January 30, 2003 - Opinon of the Scientific Committee on Plants on additional questins from the Commission concerning the evaluation of Isoxaflutole. European Commission. SCP/ISOXAFLUTOLE-BIS/002 Final 
2003 - WISCONSIN: "Pesticides containing the active ingredient isoxaflutole will not be sold in Wisconsin in 2003.
The need to protect Wisconsin’s water resources led the Department of Agriculture, Trade and Consumer Protection to require special restrictions and conditions if the corn herbicide, Balance Pro, was to be used in Wisconsin. Because of the added environmental requirements, Bayer CropScience, the pesticide manufacturer, has decided not to distribute the product in Wisconsin in 2003" ...
Wisconsin, Minnesota, and Michigan have not agreed to allow use of isoxaflutole due to concerns of "possible water contamination and effects on non-target plants, including vegetable crops.""
Wisconsin Department of Agriculture, Trade and Consumer Protection.

February 18, 2002 - European Commission decision to extend provisional authorisation granted for new active substances: carfentrazone-ethyl, cinidon-ethyl, cyhalofop-butyl, ethoxysulfuron, famoxadone, flazasulfuron, flufenacet, flumioxazine, flurtamone, fosthiazate, isoxaflutole, metalaxyl-M, prosulfuron, Pseudomonas chlororaphis, quinoxyfen, Spodoptera exigua nuclear polyhedrosis virus and sulfosulfuron
-- organofluorine pesticides highlighted in red 

October 24, 2001 - Schedule No. 1219. Canada's Food and Drug Regulations approved Maximum Residue Limits for Corn; eggs; liver of cattle and poultry; meat and meat by-products of cattle, hogs, horses, poultry & sheep; and milk to cover residues in food derived from animals fed with treated crops.  
August 25, 2000 - CHEMICALS MEETING THE CRITERIA FOR LISTING AS CAUSING CANCER VIA THE AUTHORITATIVE BODIES MECHANISM PACKAGE. Reproductive and Cancer Hazard Assessment, Section Office of Environmental Health Hazard Assessment, California Environmental Protection Agency
September 1998 - Pesticide Fact Sheet - US EPA 
September 1998 - Q&A about Isoxaflutole - US EPA 
Classified by the State of California: "Known to Cause Cancer"
Abstracts 
August 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Isoxaflutole 
October 2001 - Glossary of Pesticide Chemials. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.
April 2000 - Food and Drug Administration Pesticide Residue Monitoring. - Table 3. Pesticides detectable by methods used in 1999 regulatory monitoring.  

US Federal Register

•• Note: Due to length, the following is a partial list. Click here to see full list of FR entries.

Published Date Docket Identification Number Details
August 3, 2005 OPP-2005-0201

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Section 24(c) Registrations canceled for non-payment of the 2005
maintenance fee are shown in the following Table 1:

Table 1.--Section 24(c) Registrations Canceled for Non-Payment of Maintenance Fee

SLN no. Product Name
000264 CO-99-0005 Epic DF Herbicide
000264 OR-02-0001 Axiom DF Herbicide

Section 3 registrations canceled for non-payment of the 2005
maintenance fee are shown in the following table 2:

Table 2.--Section 3 Registrations Canceled for Non-Payment of
Maintenance Fee

Registration no. Product Name
000264-00573 EXP 31340ATZ Herbicide
Aug 9, 2000 na

AVENTIS - Issuance of Experimental Use Permit 264-EUP-129. This experimental use permit allows the use of 280 pounds of the herbicide on 2,000 acres of field corn to evaluate the control of broadleaf and grass weeds under a range of environmental conditions. The program is authorized only in the States of Michigan and Pennsylvania. The experimental use permit is effective from April 6, 2000, to April 6, 2001.

March 31, 1999 na

RHONE-POULENC - Issuance of Experimental Use Permit: 264-EUP-123. This experimental use permit allows the use of 280 pounds of the herbicide isoxaflutole on 2,000 acres of field corn to evaluate the control of various weeds. The program is authorized only in the States of Alabama, Delaware, Georgia, Idaho, Louisiana, Maryland, Michigan, Minnesota, Mississippi, Oregon, Pennsylvania, Utah, Virginia, Washington, and Wisconsin. The experimental use permit is effective from March 1, 1999 to March 1, 2000.

July 27, 1998 PF-701A

RHONE-POULENC - Pesticide Petition Filing to establish a tolerance for the combined residues of the herbicide isoxaflutole in or on the raw agricultural commodities field corn at 0.20 ppm, field corn, fodder, at 0.50 ppm, field corn, forage at 1.0 ppm; and establishing a tolerance for combined residues of the herbicide isoxaflutole in or on the meat of cattle, goat, hogs, horses, and sheep at 0.20 ppm, liver of cattle, goat, hogs, horses and sheep at 0.50 ppm, meat byproducts (except liver) of cattle, goat, hogs, horses, and sheep at 0.1 ppm, fat of cattle, goat, hogs, horses, and sheep at 0.20 ppm, liver of poultry at 0.3 ppm, eggs at 0.1 ppm and milk at 0.02 ppm. Rhone Poulenc's is amending its February 26, 1997 petition.

 
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