Return to Adverse
Effects
ACTIVITY: Insecticide,
Wood preservative, US
EPA List 3 Inert (Inorganic)
Structure:
The
major use is as a fluoridation agent for drinking water.
|
Adverse
Effects:
Anemia
Apoptosis
Ataxia
Bladder
Blood
Body Weight Decrease (including
Cachexia, Wasting, Anorexia)
Bone
Dermal
Heart
Kidney
Liver
Lung
Spleen
Poisoning
Incident |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes
US
EPA List 3 Inert |
US
EPA PC Code: |
075306 |
California
Chemical Code |
538 |
Registered
use in
(includes only a limited list of countries)
|
Australia,
Canada, India, South Africa, Tanzania, US, Vietnam |
European
Commission: |
Not
allowed to be used as an active ingredient after July 25, 2003. |
Other
Information |
Molecular
Formula: |
F6
Na2Si
INORGANIC |
Manufacturers: |
Panorama |
Other
Names: |
Sodium
fluorosilicate
Sodium hexafluorosilicate
Sodium silicofluoride
SFS
Sodium silica fluoride
Nox-All Earwig Bait Brand
--
see more synonymns in box at bottom of page |
Of
special interest: |
PAN
Data |
October
2001 - Toxicological
Summary for Sodium Hexafluorosilicate [CASRN 16893-85-9] and
Fluorosilicic Acid [CASRN 16961-83-4]. Review
of Toxicological Literature. Prepared for Scott Masten, Ph.D.,
National Institute of Environmental Health Sciences. |
TOXNET
profile from Hazardous Substances Data Bank |
November
26, 2002 - European
Commission: Sodium Fluosilicate
is one of 320 pesticides to be withdrawn
in July 2003. Some 320 substances
used in plant protection products (PPPs) - including insecticides,
fungicides and herbicides - are to be withdrawn from the market
by 25 July 2003 as part of the European Commission's new approach
to the evaluation of active substances in plant protection products.
This aims to improve safeguards to ensure that all such products
in use are safe for the environment and human health. Users,
wholesalers and retailers of plant protection products will
need to be aware of whether the products they use or sell are
likely to be withdrawn, so as to prevent them being left with
stocks of unusable material. Those concerned should contact
their national authority to check the authorisation status for
any particular product. The Regulation (n¡ 2076/2002 of 20 November
2002), with the list of the 320 substances, has now been published
in the Offical Journal. Ref: MIDDAY EXPRESS. News from the Press
and Communication Service's midday briefing. |
April
9, 2001. Australia. Exemptions Listing
TECHNICAL GRADE ACTIVE
CONSTITUENTS EXCLUDED FROM THE REQUIREMENTS OF NRA APPROVAL
The list generally includes chemicals
which have not been primarily developed as agricultural chemicals
and thus for which an extensive package of data would not be
readily available. Approval by the National Registration Authority
for these TGACs is currently not required. Fluoride
compounds exempted
include: Cupro-ammonium
Fluoroborate complex, Sodium fluoride, Sodium fluoroacetate,
Sodium fluorosilicate. |
July
11, 2001 - Material
Safety Data Sheet. GM Foam Gelling Agent. GM Foam, Inc.
DOT Shipping Name: Latex Intermediate. |
August
1999 -
Hazardous Substance
Fact Sheet - New Jersey Dept. of Health
& Senior Services |
Product
Data and Uses - PELCHEM |
June
21, 2001 - Hazardous
Materials Regulations for
Fluoride/fluorinated substances, Federal Register on Harmonization
of international shipment of Dangerous Goods. Final Rule.
|
Online
as of December 2, 2001 -
Listed
as a "Deleterious Substance" under the "Poisonous
and and Deleterious Substances Control Law" by
the National Institute of Health Sciences in Japan. |
Insecticide
products - partial list |
US
EPA List of Inerts. This
substance is on List
3.
Note:
US EPA allows so-called "Inert" ingredients to be commonly
mixed with the "active" pesticidal ingredient
to create a formulated pesticide product. According
to EPA, "The term `inert' is not intended to imply
nontoxicity; the ingredient may or may not be chemically
active." "Inert" ingredients include solvents,
emulsifiers, spreaders, and other substances mixed into
pesticide products to increase the effectiveness of the
active ingredients, make the product easier to apply, or
to allow several active ingredients to mix in one solution.
Both US EPA and California Department of Pesticide Regulation
require pesticide manufacturers to identify inert ingredients
in their products but do not disclose this information to
the general public because the pesticide industry considers
product formulations trade secrets, protected by law and
by the US EPA. The US EPA category of Inerts (as of September
2003):
List 1 - Of Toxicological
Concern
List 2 - Potentially
Toxic / High Priority for Testing
List
3 - Of Unknown Toxicity
List 4A - Generally Regarded as Safe
List 4B - EPA states it has Sufficient Information to Reasonably
Conclude that the Current Use Pattern in Pesticide Products
will not Adversely Affect Public Health or the Environment
List
4 (all)
See
good report: Toxic
Secrets": "Inert" Ingredients in Pesticides
1987-1997, published by Northwest
Coalition for Alternatives to Pesticides.
|
Full
free report available at: http://www.fluoride-journal.com/03-36-4/364-231.pdf
Fluoride
Vol. 36 No. 4 231-240 2003
- Research Report 231
THE INFLUENCE
OF SODIUM FLUORIDE AND SODIUM HEXAFLUOROSILICATE ON HUMAN
LEUKEMIC CELL LINES
Boguslaw
Machalinski (a), Magdalena Baskiewicz-Masiuk (a), Bogna
Sadowska (a), Anna Machalinska (b), Mariola Marchlewicz
(b), Barbara Wiszniewska (b), Iwona Stecewicz (a)
For Correspondence: Boguslaw Machalinski, MD, PhD., D.Sci.
(a) Department of General Pathology, Pomeranian Academy
of Medicine (PAM), Al. Powstancow Wlkp. 72, 70-111 Szczecin,
Poland. E-mail: machalin@sci.pam.szczecin.pl
(b) Department of Histology and Embryology, PAM, Al. Powstancow
Wlkp. 72, 70-111 Szczecin, Poland.
SUMMARY:
Although potential toxic effects of sodium fluoride on early
progenitor and stem cells have been reported previously,
surprisingly few investigations have examined the effects
of fluoride on human leukemic cells. To address this need,
four different human leukemic cell lines (HL-60, HEL, TF-1,
and K562) were exposed to increasing levels (0, 0.24, and
1.19 mM F) of two forms of fluoride: sodium fluoride (NaF)
and sodium hexafluorosilicate (Na2SiF6). Because of its
widespread use in water fluoridation, Na2SiF6 was investigated
in addition to NaF. The early response
effect of Na2SiF6 was greater, and in several cases significantly
greater, than NaF on clonogenic growth
and the induction of apoptosis in
all four cell lines. These findings show that human
leukemic cells can be influenced and damaged by fluorine
compounds.
|
"Sodium
fluosilicate (sodium silico fluoride) has been used to control
ectoparasites on livestock, as well as crawling insects
in homes and work buildings. It is approximately as toxic
as sodium fluoride [highly toxic to all plant and animal
life]. All uses in the U.S. have been cancelled."
-- Note from FAN: Unfortunately,
this is not correct. Sodium fluosilicate is permitted to
be used in pesticides
as a List 3
Inert.
Ref: Recognition and
Management of Pesticide Poisonings, 5th Edition, Chapter
8.
The Office of Pesticide Programs, US EPA
http://www.epa.gov/oppfead1/safety/healthcare/handbook/Chap08.pdf
The
major use of sodium hexafluorosilicate [sodium
fluosilicate] and fluorosilicic acid is as fluoridation
agents for drinking water. Sodium
hexafluorosilicate has also been used for caries control
as part of a silicophosphate cement, an acidic gel in combination
with monocalcium phosphate monohydrate, and a two-solution
fluoride mouth rinse. Both chemicals are also used as a
chemical intermediate (raw material) for aluminum trifluoride,
cryolite (Na3AlF6), silicon tetrafluoride, and other fluorosilicates
and have found applications in commercial laundry. Other
applications for sodium hexafluorosilicate include its use
in enamels/enamel frits for china and porcelain, in opalescent
glass, metallurgy (aluminum and beryllium), glue, ore flotation,
leather and wood preservatives,
and in insecticides and rodenticides.
It has been used in the manufacture of pure silicon, as
a gelling agent in the production of molded latex foam,
and as a fluorinating agent in organic synthesis to convert
organodichlorophosphorus compounds to the corresponding
organodifluorophosphorus compound. In veterinary practice,
external application of sodium hexafluorosilicate
combats lice and mosquitoes on cattle, sheep, swine, and
poultry, and oral administration combats roundworms and
possibly whipworms in swine and
prevents dental caries in rats.
Apparently, all pesticidal products had their registrations
cancelled or they were discontinued by the early 1990s...
Exposure to sodium hexafluorosilicate is possible from its
use to control crawling insects in
homes and work buildings. The chemical has "high
inherent toxicity," and children may ingest the material
from crawling on the floors of treated houses (U.S. EPA,
1999).
Ref:
Toxicological Summary for Sodium Hexafluorosilicate [CASRN
16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4]. Review
of Toxicological Literature. October 2001. Prepared for
Scott Masten, Ph.D. National Institute of Environmental
Health Sciences.
http://ntp-server.niehs.nih.gov/htdocs/Chem_Background/ExSumPDF/Fluorosilicates.pdf
|
Sodium
hexafluorosilicate ([Na2SiF6] is also called: |
Destruxol
applex
Disodium hexafluorosilicate
Disodium silicofluoride
Ens-zem weevil bait
ENT 1,501
Fluorosilicate
de sodium
Fluosilicate de sodium
Ortho earwig bait
Ortho weevil bait
Prodan
Prodan (pesticide)
|
PSC
Co-Op weevil bait
Safsan
Salufer
Silicate (2 - ), hexafluoro-, disodium (8CI, 9CI)
Silicon sodium fluoride
Sodium
fluoride silicate
Sodium fluorosilicate
Sodium fluosilicate
Sodium silicofluoride
Sodium silicon fluoride
Super prodan UN2674 (DOT) |
Related
Chemicals:
Ref: Pesticide Action Network (PAN)
|
CAS No. |
Relation |
Chemical Name |
PAN
& FAN data |
Some
Notes from FAN: |
16893-85-9 |
Parent
* |
Sodium
fluosilicate |
PAN |
US
EPA List 3 inert
Registered
in:
Australia, Canada, India, South Africa, Tanzania, Vietnam
UK:
Cancelled
|
16919-19-0 |
Related
(1) |
Ammonium
fluosilicate |
PAN
FAN |
US
EPA List 3 inert
SYN:
Ammonium
silicofluoride |
62449-69-8 |
Related
(1) |
Ammonium
fluosilicate on silica gel |
PAN
FAN |
SYN:
Barium hexafluorosilicate |
17125-80-3 |
Related
(1) |
Barium
fluosilicate |
PAN
FAN |
Registered
in: India
EU:
Not allowed to be used as an active ingredient after July
25, 2003
SYN:
Barium hexafluorosilicate |
12062-24-7 |
Related
(1) |
Cupric
fluosilicate |
PAN
FAN |
SYN:
Copper silicofluoride,
Cupric hexafluorosilicate |
1327-43-1 |
Related
(1) |
Magnesium
aluminum fluosilicate |
PAN
FAN |
US
EPA List 3 inert |
16949-65-8 |
Related
(1) |
Magnesium
fluosilicate |
PAN
FAN |
- |
53404-77-6 |
Related
(1) |
Sodium
aluminum fluosilicate |
PAN
FAN |
- |
16871-71-9 |
Related
(1) |
Zinc
fluosilicate |
PAN
FAN |
PAN
Bad Actor Chemical:
Developmental or Reproductive Toxin
SYN:
Zinc silicofluoride |
Explanation
from PAN: |
*
Parent: Compounds labeled with a "P" are the parent
compound of the group. The parent chemical was chosen on the
basis of available toxicity information, where chemicals with
the maximum amount of toxicity information assigned to parent
status. Where no toxicity information was available for any
member of a group, we assigned parent status to the least
derivatized member of the group for organic compounds (e.g.,
benzoic acid would be the parent instead of methyl benzoate),
the sodium salt (for compounds with a common anion), or the
chloride salt (for compounds with a common cation). These
are general guidelines and not hard and fast rules, because
the groups are rarely so easy to categorize. For some groups
with no obvious parent, assignment of parent status was arbitrary. |
Group
1: Salts, esters and/or complexes of the parent chemical,
e.g., glyphosate and glyphosate, isopropylamine salt; 2,4-D
and 2,4-D, butoxyethyl ester. Alternatively, the parent
compound itself is an ester or salt, and related compounds
are other esters or salts.
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