Reports
available from The National Technical Information Service
(NTIS) -
see http://www.ntis.gov/ |
Order
No. |
Title |
Keywords |
CAS
Nos. |
NTIS/OTS0559049
EPA/OTS;
Doc #88970000062 |
1996
- INITIAL
SUBMISSION: UNTERSUCHUNG AUF SENSIBILISIERENDE WIRKUNG
BEI MEERSCHWEINCHEN, WITH TSCA HEALTH & SAFETY STUDY
COVER SHEET DATED 11-19-1996
BAYER
AG |
BAYER CORP
TOLYFLUANID(PREVENTOL A5)
HEALTH EFFECTS
PRIMARY DERMAL SENSITIZATION
MAMMALS
GUINEA PIGS
DERMAL |
731-27-1
|
NTIS/OTS0559050
EPA/OTS;
Doc #88970000063 |
1996
- INITIAL
SUBMISSION: KUE 13183b, EUPAREN M - WIRKSTOFF, GENERATIONSVERSUCH
AN RATTEN, WITH TSCA HEALTH AND SAFETY STUDY COVER SHEET
DATED 11-19-1996 |
BAYER
CORP
TOLYFLUANID(PREVENTOL A5)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
COMBINED TERATOGENICITY/REPRODUCTIVE EFFECTS
MAMMALS
RATS
ORAL
DIET |
731-27-1
|
NTIS/OTS0545057
EPA/OTS;
Doc #88-920006458 |
1992
- INITIAL
SUBMISSION: TOXICITY STUDIES WITH DICHLOFLUANID & TOLYLFLUANID
IN RATS, MICE, AND DOGS WITH COVER LETTER DATED 09-21-92
|
MILES
INC
DICHLOFLUANID & TOLYLFLUANID
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
DOGS
RATS
MICE
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
RABBITS |
731-27-1
1085-98-9
|
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16545431&query_hl=1&itool=pubmed_docsum
Sci Total Environ. 2006 Mar 15;
[Epub ahead of print]
Comparative toxicity of alternative antifouling
biocides on embryos and larvae of marine invertebrates.
Bellas J.
Departamento de Ecoloxia e Bioloxia Animal, Universidade de Vigo,
Estrada, Colexio Universitario s/n, 36310 Vigo, Galicia, Spain.
This study evaluates the impact of commonly used "booster"
biocides (chlorothalonil, Sea-Nine 211, dichlofluanid, tolylfluanid
and Irgarol 1051) on early developmental stages of marine invertebrates
of commercial and ecological relevance. Toxicity tests were conducted
with embryos and larvae of the bivalve Mytilus edulis, the sea-urchin
Paracentrotus lividus and the ascidian Ciona intestinalis. Toxicity
was quantified in terms of the EC(50) (median effective concentration)
and EC(10) reducing embryogenesis success, larval growth and larval
settlement by 50% and 10% respectively. The EC(10) and EC(50)
for chlorothalonil ranged from 2 to 108 and from 25 to 159 nM;
for Sea-Nine 211 values were 6-204 and 38-372 nM; for dichlofluanid
effective concentrations were 95-830 and 244-4311 nM; tolylfluanid
yielded values between 99-631 and 213-2839 nM; and Irgarol
1051 was the least toxic compound showing values from 3145 to
>25600 and from 6076 to >25600 nM. Those biocides may be
ranked in the following order from highest to lowest toxicity
to embryos and larvae of M. edulis, P. lividus and C. intestinalis:
chlorothalonil>Sea-Nine 211>dichlofluanid=tolylfluanid>Irgarol
1051. The registered effective concentrations were compared to
worst-case environmental concentrations reported in literature
in order to evaluate the risk posed by these biocides to those
invertebrate species. Our data support that chlorothalonil, Sea-Nine
211 and dichlofluanid predicted levels in marinas represent a
threat to M. edulis, P. lividus, and C. intestinalis populations,
whilst Irgarol 1051 showed no toxic effects on the biological
responses tested here at worst-case environmental concentrations.
Excerpts:
• This is, in our knowledge the first
report of tolylfluanid and dichlofluanid toxicity to marine organisms.
• Reported maximum concentrations in marinas and polluted
estuaries are shown in Table 3, except for
tolylfluanid, since no data was found in literature.
• the embryonic development of P. lividus and M.
edulis was more sensitive to chlorothalonil and Sea-Nine 211 than
the embryogenesis and larval settlement of C. intestinalis, the
settlement of C. intestinalis larvae was more sensitive to tolylfluanid
and dichlofluanid.
PMID: 16545431 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16449059&query_hl=1&itool=pubmed_docsum
Food Addit Contam. 2006 Feb;23(2):164-73.
Monitoring of pesticide residues in apples,
lettuce and potato of the Slovene origin, 2001-04.
Cesnik HB, Gregorcic A, Bolta SV, Kmecl
V.
Agricultural Institute of Slovenia, Central Laboratories, Ljubljana,
Slovenia. helena.basa@kis.si
Apples, lettuce and potatoes (404 samples) produced in the Republic
of Slovenia were analysed for pesticide residues at the Agricultural
Institute of Slovenia, Ljubljana, in 2001-04. Sampling from eight
agricultural production areas was performed at market producers
at the harvesting of products or in storehouses after the pre-harvest
interval of plant protection products used. Samples
exceeding the maximum residue levels were the following: three
apple samples (2.0%) containing 0.33-2.24 mg kg(-1) (phosalone
and tolylfluanid), three lettuce samples (3.1%) containing
0.14-6.36 mg kg(-1) (dimethoate, dithiocarbamates and metalaxyl)
and 36 potato samples (23.1%) containing 0.06-0.51 mg kg(-1) (dithiocarbamates).
Residues of two or more active substances were found in 73 apple
samples (48.3%), of which the maximum residue limit (MRL) was
exceeded by three samples (2.0%) with the values ranging from
0.33 to 2.24 mg kg(-1), and nine lettuce samples (9.3%), for which
the MRL was exceeded by three samples (3.1%) with values from
0.14 to 6.36 mg kg(-1). In potato samples, only residues of dithiocarbamates
or no residues at all were found. Residues of the dithiocarbamate
group were the most frequently found, i.e. in 66 apple samples
(43.7%), 30 lettuce samples (30.9%) and 38 potato samples (24.4%).
PMID: 16449059 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16356887&query_hl=1&itool=pubmed_docsum
Food Addit Contam. 2005 Dec;22(12):1231-42.
Baby food production chain: pesticide residues
in fresh apples and products.
Stepan R, Ticha J, Hajslova J, Kovalczuk
T, Kocourek V.
Department of Food Chemistry and Analysis, Institute of Chemical
Technology (ICT) Prague, Technicka 5, Prague 6, 16628, Czech Republic.
During 3 years of a monitoring programme, 522 samples of fresh
apples, six brands of fruit purees and various types of fruit
baby food prepared from these materials were analysed. Each sample
was examined for the presence of 86 GC amenable pesticide residues.
The reporting limits of the procedure employed for sample analyses
were in the range 0.003-0.01 mg kg(-1). Pesticide residues were
detected in 59.5% of the samples of fresh apples. However, maximum
residue levels (European Union MRLs) were exceeded only in 1.4%
of samples. The levels of residues in 'positive' fruit purees
were substantially lower, overall with residues detected in 33%
of samples. Fruit baby food represented the commodity with the
lowest incidence of residues being detected in only 16% of samples.
The 0.01 mg kg(-1) MRL was exceeded in 9% of these products. Multiple
residues were found in 25% of fresh apples and in 10% of fruit
purees. None of fruit baby food samples contained more than a
single residue. Organophosphorus insecticides and fungicides representing
phtalimides, sulphamides and dicarboximides were the most frequently
found residues. To obtain more knowledge on the fate of residues
during fruit baby food production, processing experiments employing
apples with incurred residues (fenitrothion, phosalone and tolylfluanid)
were conducted. Washing of apples did not significantly reduce
the content of pesticides. Steam boiling followed by removal of
peels/stems was identified as the most efficient steps in terms
of residues decrease (phosalone) or complete elimination (fenitrothion
and tolylfluanid).
PMID: 16356887 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15941588&query_hl=1
Ecotoxicol Environ Saf. 2005 Jun
4; [Epub ahead of print]
Chromosomal aberrations and frequency of
micronuclei in sheep subchronically exposed to the fungicide Euparen
Multi (tolylfluanid).
Sutiakova I, Kovalkovicova N, Pistl J,
Novotny J, Legath J, Kovac G, Hlincikova S, Sutiak V.
University of Veterinary Medicine, Komenskeho 73, 041 81 Kosice,
Slovak Republic.
We analyzed chromosome aberrations, micronucleus frequency, mitotic
index (MI), and nuclear division index (NDI) in peripheral lymphocytes
of sheep subchronically exposed to the fungicide Euparen Multi
(containing 50% tolylfluanid). Euparen Multi was administered
by rumen sonde to group of Merino sheep (seven sheep/group) at
93mg/kg body weight (1/20 LD(50)) daily for 28 days to assess
its genotoxic effects. The frequencies of aberrant cells (ABC)
in the experimental and control groups were 5.50+/-1.38% and 2.40+/-1.14%,
respectively, and the increase in ABC in the treated group was
significant (P=0.003). Significantly increased
numbers of chromatid breaks (5.67+/-1.21% against 2.40+/-1.14%;
P=0.001), chromatid gaps (10.33+/-2.73% against 4.00+/-1.23%;
P=0.001), and chromosome gaps (1.83+/-0.75% against 0.80+/-0.45%;
P=0.025) and exchanges (3.17+/-1.94% against 0.20+/-0.45%; P=0.009)
were observed in exposed animals in comparison to control animals.
The frequency of micronuclei (MN) was 29.40+/-5.86 per
1000 binucleated cells in peripheral lymphocytes of sheep in the
control group and 49.57+/-19.12 per 1000 binucleated cells in
the treated group. A significant increase in the frequency of
MN in peripheral lymphocytes also was observed between the two
groups (P=0.0477). No statistical differences in MI and NDI values
were found in the groups (P=0.181 and 0.761, respectively). Thus,
our results suggest that exposure to Euparen Multi may cause genome
damage in somatic cells.
PMID: 15941588
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15755314&query_hl=1
Basic Clin Pharmacol Toxicol. 2005
Apr;96(4):309-15.
Xenobiotics and the glucocorticoid receptor:
additive antagonistic effects on tyrosine aminotransferase activity
in rat hepatoma cells.
Johansson M, Johansson N, Lund BO.
Department of Environmental Toxicology, Uppsala University, Norbyvagen
18A, SE-752 36 Uppsala, Sweden. maria.k.johansson@astra.zeneca.com
Methylsulfonyl-PCBs (MeSO2-PCBs) and some fungicides were studied
for their functional effects on the glucocorticoid signal transduction
in the Reuber rat hepatoma H-II-E-C3 cell line. 4-Substituted
MeSO2-PCBs, tolylfluanid and ketoconazole displayed antagonistic
effects on dexamethasone-induced tyrosine aminotransferase specific
activity (IC50 ranging from 0.7-5.1 microM), but no agonist activity.
These substances also had affinity to the mouse glucocorticoid
receptor in competition binding studies, indicating that the inhibition
of the middle cerebral artery occlusion-activity is indeed mediated
by receptor binding. Thus, substances with
a structural resemblance with a methyl sulfonyl group, such as
the fungicide tolylfluanid, may inhibit glucocorticoid receptor-regulated
gene transcription. In co-exposure experiments with three
substances, multivariate modelling showed that the inhibitory
effect of 4-MeSO2-2,5,6,2',4'-pentachlorobiphenyl (4-MeSO2-CB91),
4-MeSO2-2,3,6,2',4',5'-hexachlorobiphenyl (4-MeSO2-CB149) and
tolylfluanid on tyrosine aminotransferase activity was close to
additive. Thus, co-exposure to such
different chemicals as persistent organic pollutants and pesticides
may affect cells additively. Chemical interference with
the glucocorticoid hormone system therefore deserves further attention
in vivo.
PMID: 15755314 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14668155
Food Addit
Contam. 2003 Nov;20(11):1044-63.
Distribution of multiple pesticide residues in apple segments
after home processing.
Rasmusssen
RR, Poulsen ME, Hansen HC.
Danish Veterinary
and Food Administration, Morkhoj Bygade 19, DK-2860 Soborg, Denmark.
riro@fdir.dk
The effects
of washing, storing, boiling, peeling, coring and juicing on pesticide
residue were investigated for field-sprayed Discovery and Jonagold
apples. Residues of chlorpyrifos, cypermethrin, deltamethrin,
diazinon, endosulfan, endosulfan sulfate, fenitrothion, fenpropathrin,
iprodione, kresoxim-methyl, lambda-cyhalothrin, quinalphos, tolylfluanid
and vinclozolin in the processed apples were analysed by
gas chromatography. Statistical analysis showed that reductions
of 18-38% were required to obtain significant effects of processing
practices, depending on pesticide and apple variety. Juicing and
peeling the apples significantly reduced all pesticide residues.
In the case of detectable pesticide residues, 1-24% were distributed
in the juice and in the peeled apple. None
of the pesticide residues was significantly reduced when the apples
were subject to simple washing or coring. Storing significantly
reduced five of the pesticide residues: diazinon, chlorpyrifos,
fenitrothion, kresoxim-methyl and tolylfluanid,
by 25-69%. Residues of the metabolite endosulfan sulfate were
increased by 34% during storage. Boiling
significantly reduced residues of fenitrothion and tolylfluanid
by 32 and 81%, respectively. Only a few of the observed
effects of processing could be explained by the physical or chemical
characteristics of the pesticides. No differences in effect of
processing due to apple variety were identified.
PMID: 14668155
[PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13129790
Food Addit
Contam. 2003 Aug;20(8):728-41.
Processing
factors and variability of pyrimethanil, fenhexamid and tolylfluanid
in strawberries.
Christensen HB, Granby K, Rabolle M.
Danish Veterinary and Food Administration, Soborg, Denmark. hbc@fdir.dk
An HPLC-MS/MS method for the analysis of three pesticides in strawberries
was developed and validated. Recoveries were measured at three
spiking levels and ranged from 85 to 99% (mean recoveries). The
effects of processing of strawberries ranging from rinsing to
jam production were investigated for the three fungicides tolylfluanid,
fenhexamid and pyrimethanil, which were applied under field conditions.
Kresoxim-methyl was also applied in the field, but was not found
in any of the samples investigated. The effect of parameters such
as preharvest interval, dose, harvest time and observed pesticide
concentration after harvest (initial concentration, mg kg(-1)),
were examined with respect to possible reduction of the pesticides.
The results from rinsing showed that all
three pesticides were reduced on average by 37% for tolylfluanid,
by 34% for fenhexamid and by 19% for pyrimethanil.
For tolylfluanid and fenhexamid, the initial concentration significantly
affected the reduction. For fenhexamid, dose could also
have a minor influence on reduction. For pyrimethanil, none of
the parameters significantly influenced the reduction.
For jam production, cooking significantly reduced tolylfluanid
by an average of 91%. For fenhexamid and pyrimethanil,
a smaller reduction was seen, 25% and 33%, respectively. The
reduction of tolylfluanid and pyrimethanil was affected by the
preharvest interval, while fenhexamid was affected by the
initial concentration. The unit-to-unit variability of fungicide
contents was also investigated and the variability factors for
the three fungicides were from 1.9 to 2.8.
PMID: 13129790
[PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11804510&dopt=Abstract
J Agric Food
Chem 2002 Jan 30;50(3):441-8
Assessment
of the stability of pesticides during cryogenic sample processing.
1. Apples.
Fussell RJ, Jackson Addie K, Reynolds
SL, Wilson MF.
Central Science Laboratory, Sand Hutton, York
YO41 1LZ, United Kingdom.
An assessment of the stability of a large number
(106) of pesticides and related compounds during the cryogenic
sample processing of apples has been undertaken. For the first
time the procedure included an assessment of the losses during
the freezing of the fruits, prior to processing. The stability
of each pesticide during processing was assessed by comparing
the mean recovery for the laboratory-spiked samples with the mean
"survival" of the pesticides in cryogenically processed samples.
The results clearly demonstrate that the vast majority, 94 of
106, of pesticides were stable during cryogenic processing.
Of particular importance was that losses of several pesticides
[bitertanol (95%), heptenophos (50%), isofephos (40%), and tolylfluanid
(48%)] reported to occur during ambient
processing of apples did not occur during cryogenic processing.
Losses of dichlofluanid (54%), chlozolinate (22%), and etridiazole
(40%), previously reported to occur during ambient processing
of apples, were reduced to barely significant levels (10, 17,
and 14%, respectively) by cryogenic processing. Small apparent
losses for a few of the compounds were attributable to analytical
and sample handling difficulties, rather than to losses during
processing, and need further investigation.
PMID: 11804510 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10725174&dopt=Abstract
J Agric Food
Chem 2000 Mar;48(3):917-20
Investigation
on fungicide residues in greenhouse-grown strawberries.
Stensvand A, Christiansen A.
The Norwegian Crop Research Institute, Pesticide
Laboratory, Osloveien 1, 1430 As, Norway.
Maximum residue limits (MRL's) for different agricultural food
products in Norway are harmonized with EU standards. In field-grown
strawberries in Norway, tolylfluanid has a 7 day quarantine from
last application to harvest, while other approved fungicides have
14 days quarantine. Greenhouse production of strawberries is newly
introduced to the country. Residue levels in strawberries of the
cultivar Korona grown in a commercial greenhouse were investigated
4, 7, and 14 days after application of eight different fungicides
at rates recommended by the manufacturers and at half rates. Iprodione,
tolylfluanid, and vinclozolin were
tested in two experiments, while chinomethionat, chlorothalonil,
imazalil, penconazole, and triadimefon were tested once. For chinomethionat,
imazalil, iprodione, penconazole, and vinclozolin, the residue
levels were below MRL 2 weeks after application. Application of
triadimefon in normal rate gave residues below MRL 14 days after
application. However, its metabolite, triadimenol, was above MRL
at the same time. Tolylfluanid gave very
high residue levels, and except from half concentration in the
second experiment, all other residue levels were above MRL. Seven
days after application, residues in both experiments were approximately
3 times higher than MRL when normal rate of tolylfluanid was applied.
For chlorothalonil at the recommended rate, the residue
level was above MRL at any sampling time, while half rate gave
residues below MRL 14 days after treatment.
In view of the present results, tolylfluanid, chlorothalonil,
and triadimefon will need longer time from last application to
harvest and/or reduced application rates in greenhouse-grown compared
to field-grown strawberries. In addition or as an alternative,
recommended rates could be lowered.
PMID: 10725174 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10635545&dopt=Abstract
Am Ind Hyg
Assoc J 1999 Nov-Dec;60(6):789-93
Exposure
to fungicides in fruit growing: re-entry time as a predictor for
dermal exposure.
Tielemans E, Louwerse E, de Cock
J, Brouwer D, Zielhuis G, Heederik D.
Department of Environmental Sciences, University
of Wageningen, The Netherlands.
As part of a European Concerted Action on Male
Reproduction Capability an exposure assessment survey was conducted
among seasonal workers in the fruit growing sector in the Netherlands.
Dermal exposure to the fungicides captan and tolylfluanid
was measured using cotton gloves (12 persons) and skin pads on
several body parts (12 persons). In addition, a set of exposure
data was used from a study conducted recently among Dutch fruit
growers. For harvesting activities, re-entry
time appeared to be an important determinant of dermal exposure
to captan and tolyfluanid. Explained variance of regression
models was moderate to high (range 0.30-0.87). For captan, calculated
half-life times from the most recent exposure survey were lower
(glove data: 5 days; pad data: 6 days) compared with half-life
times based on the previously conducted study (11 days). Possible
explanations for the discrepancy are discussed.
For tolylfluanid, estimated half-life times during harvesting
were 2 and 3 days, based on pad and glove data, respectively.
Prediction of captan exposure during other crop activities
appeared to be far more difficult (explained variance equal to
0.06), although the estimated half-life time was comparable with
that for harvesting. The data suggest that re-entry time gives
useful information to group workers in broad exposure categories.
Nonetheless, it
was concluded that large studies are needed to evaluate the importance
of re-entry time in more detail.
Publication Types:
PMID: 10635545
[PubMed - indexed for MEDLINE]
From Toxline at Toxnet
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY; 37 (3).
1999. 415-423.
Human semen quality in relation to dietary
pesticide exposure and organic diet.
JUHLER RK, LARSEN SB, MEYER O, JENSEN ND,
SPANO M, GIWERCMAN A, BONDE JP
Department of Geochemistry, Geological Survey of Denmark and
Greenland, GEUS, Thoravej 8, 2400, Copenhagen NV, Denmark.
BIOSIS COPYRIGHT: BIOL ABS. The objective of the study was to
corroborate or refute the hypothesis that farmers having a high
intake of organic grown commodities have a high semen quality
due to their expected lower level of dietary pesticides intake.
Food frequency data and semen were collected from 256 farmers
(171 traditional farmers and 85 organic farmers, overall participation
rate: 32%) who were selected from central registers. Each farmer
delivered one semen sample before the spraying season started.
The farmers wer ual mean intake of single commodities, such as
rice, potato, and pork meat. The current individual dietary intake
of 40 pesticides was estimated using food frequencies and generalized
serving size data in combination with data on pesticide concentrations
in food commodities as obtained from the National Danish Food
Monitoring Program. The estimated pesticide
intake was significantly lower among farmers of group H, but for
all three groups of farmers the average dietary intake of 40 pesticides
wa The group of men without
organic food intake had a significant lower proportion of morphologically
normal spermatozoa, but in relation to 14 other semen parameters
no significant differences werefound between the groups. Intake
of 40 individual pesticides was correlated with four semen parameters
(concentration, percentage dead spermatozoa, percentage normal
sperm heads, and motility (VCL)).
Five significant correlations (p value 0.01) were found among
the 160 comparisons in relation to percent sion, the estimated
dietary intake of 40 pesticides did not entail a risk of impaired
semen quality, but precautions should be taken when generalizing
this negative result to populations with a higher dietary exposure
level or an intake of other groups of pesticides.
CAS Registry Numbers:
50471-44-8 - Vinclozolin
32809-16-8 - procymidone
2595-54-2 - mecarbam
731-27-1 - Tefluthrin
36734-19-7 - iprodione
10605-21-7 - carbendazim
1825-21-4
10265-92-6 - methamidophos
13457-18-6 - pyrazophos
2597-03-7 - phenthoate
1897-45-6 - chlorothalonil
80-33-1 - chlorfenson
29232-93-7 - pirimiphos-methyl
13593-03-8 - quinalphos
18181-80-1 - bromopropylate
2310-17-0 - phosalone
148-79-8 - thiabendazole
30560-19-1 - acephate
2921-88-2 - chlorpyrifos
950-37-8 - methidathion
732-11-6 - phosmet
563-12-2 - ethion
333-41-5 - diazinon
298-00-0 - parathion-methyl
133-06-2 - captan
122-39-4 - diphenylamine
122-14-5 - fenitrothion
116-29-0 - tetradifon
115-32-2 - dicofol
115-29-7 - endosulfan
99-30-9 - dicloran
92-52-4 - biphenyl
90-43-7 - 2-phenylphenol
87-86-5 - pentachlorophenol
86-50-0 - azinphos-methyl
63-25-2 - carbaryl
60-51-5 - dimethoate
58-89-9 - lindane
56-38-2 - parathion
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1854993&dopt=Abstract
Bull Environ
Contam Toxicol 1991 Apr;46(4):499-506
No
Abstract available
Fate
of the fungicide tolylfluanid in the pear cold stored in controlled
or non controlled
atmosphere.
Rouchaud
J, Gustin F, Creemers P, Goffings G, Herregods M.
Laboratory
of Phytopathology, Catholic University of Louvain, Belgium.
PMID: 1854993
[PubMed - indexed for MEDLINE]
From Toxline at Toxnet
FAO Plant production and protection paper Vol:93/2 (1988)
pp 61-73
Tolylfluanid
FAO and WHO working groups
Level causing no toxicological effect
Rat: 300 ppm in the diet, equal to
15 mg/day bw/day
Dog: 12.5 mg/kg bw/day
Human: Estimate of acceptable daily intake for man 0-0.1 mg/kg
bw
Studies which will provide information valuable for the continued
evaluation of the compound Observations in man.
Return
to Tolyfluanid Index page