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Trifluralin. Hazard Summary prepared by the Office of Air Quality Planning & Standards. US EPA.


From:  http://www.epa.gov/ttn/uatw/hlthef/trifural.html

TRIFLURALIN

1582-09-8

Hazard Summary

CAUTION: Unless otherwise noted, the quantitative information on these fact sheets are from "EPA Health Effects Notebook for Hazardous Air Pollutants-Draft", EPA-452/D-95-00, PB95-503579, December 1994." Please conduct a current literature search and check the appropriate current online database for the most recent quantitative information.


a Milligrams per kilogram per day is one way to measure the amount of the contaminant that is consumed in food.
b The RfD is not a direct estimator of risk but rather a reference point to gauge the potential effects. Exceedance of the RfD does not imply that an adverse health effect would necessarily occur. As the amount and frequency of exposures exceeding the RfD increase, the probability of adverse health effects also increases.
c The 1/ED10 value is a measure of the carcinogenic potency of a chemical. The value reported here has been proposed in the hazard ranking of hazardous air pollutants in EPA's proposed rulemaking (Section 112(g) of the Clean Air Act, April 1994).

Please Note: The main sources of information for this fact sheet are EPA's Integrated Risk Information System (IRIS), which contains information on oral chronic toxicity and the RfD, and the carcinogenic effects of trifluralin including the unit cancer risk for oral exposure, and EPA's Health and Environmental Effects Profile for Trifluralin. Other secondary sources include the Hazardous Substances Data Bank (HSDB), a database of summaries of peer-reviewed literature, and the Registry of Toxic Effects of Chemical Substances (RTECS), a database of toxic effects that are not peer reviewed.

Environmental/Occupational Exposure

Assessing Personal Exposure

Health Hazard Information


Acute Effects:


Chronic Effects (Noncancer):


Reproductive/Developmental Effects:


Cancer Risk:

Physical Properties

Uses



Conversion Factors:
To convert from ppm to mg/m3: mg/m3 = (ppm) × (molecular weight of the compound)/(24.45). For trifluralin: 1 ppm = 13.71 mg/m3.

Health Data from Oral Exposure

Concentration (mg/kg/d)
Health numbersa
Regulatory, advisory numbersb
Reference
10,000.0
  • LD50 (rats)
    (>10,000 mg/kg)

2
--
--
--
--
1,000.0
  • LD50 (mice)
    (3,197 mg/kg)
  • LD50 (rabbits)
    (>2,000 mg/kg)

2
2
--
--
--
--
100.0



--
--
--
--
10.0



--
--
--
--
1.0
  • LOAELc (dogs)
    (3.75 mg/kg/d)

3
--
--
--
--
0.1
  • NOAELc (dogs)
    (0.75 mg/kg/d)

3
--
--
--
--
0.01



--
--
--
--
0.001
  • RfD (0.0075 mg/kg/d)

3

LD50 (Lethal Dose50)--A calculated dose of a chemical in water to which exposure for a specific length of time is expected to cause death in 50% of a defined experimental animal population.
LOAEL--Lowest-observed-adverse-effect level.
NOAEL--No-observed-adverse-effect level.
RfD--Reference dose.

a Health numbers are toxicological numbers from animal testing or risk assessment values developed by EPA.
b Regulatory numbers are values that have been incorporated in Government regulations, while advisory numbers are nonregulatory values provided by the Government or other groups as advice.
c The LOAEL and NOAEL are from the critical study used as the basis for the EPA RfD.

References

  1. U.S. Department of Health and Human Services. Hazardous Substances Data Bank (HSDB, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.
  2. U.S. Department of Health and Human Services. Registry of Toxic Effects of Chemical Substances (RTECS, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.
  3. U.S. Environmental Protection Agency. Integrated Risk Information System (IRIS) on Trifluraline. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1993.
  4. U.S. Environmental Protection Agency. Health and Environmental Effects Profile for Trifluraline. EPA/600/x-84/234. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1984.
  5. U.S. Environmental Protection Agency. Technical Background Document to Support Rulemaking Pursuant to the Clean Air Act--Section 112(g). Ranking of Pollutants with Respect to Hazard to Human Health. EPA­450/3-92-010. Emissions Standards Division, Office of Air Quality Planning and Standards, Research Triangle Park, NC. 1994.
  6. The Merck Index. An Encyclopedia of Chemicals, Drugs, and Biologicals. 11th ed. Ed. S. Budavari. Merck and Co. Inc., Rahway, NJ. 1989.
  7. M. Sittig. Handbook of Toxic and Hazardous Chemicals and Carcinogens. 2nd ed. Noyes Publications, Park Ridge, NJ. 1985.


1. *Micrograms per liter is the unit of measurement for chemicals in water.


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May 17, 2001