A new study shows that fluoride disrupts mitochondria by affecting a protein called MRPL15, which is controlled by another protein, C/EBPa. This disruption causes mitochondria to produce too many harmful molecules (mtROS), which trigger inflammation and cell death in the brain, leading to memory issues.

The study also found that curcumin, a natural substance, can help reduce these harmful effects by improving mitochondrial function and calming inflammation.

Study Highlights:

• Upregulation of C/EBPa and MRPL15 induces neuronal pyroptosis by mtROS accumulation from translational defects.
• Fluoride-induced cognitive deficits involve neuroinflammation from mitochondrial translation dysfunction.
• Curcumin reduces fluoride neuroinflammation by targeting pyroptosis through C/EBP? and MRPL15 downregulation.