At least 13 Nobel Prize winners in Chemistry and Medicine have either opposed fluoridation or expressed reservations about it. These include:

• Arvid Carlsson (2000, Medicine/Physiology)
• Giulio Natta (1963, Chemistry),
• Nikolai Semenov (Chemistry, 1956),
• Sir Cyril Norman Hinshelwood (Chemistry, 1956),
• Hugo Theorell (Medicine, 1955),
• Walter Rudolf Hess (Medicine, 1949),
• Sir Robert Robinson (Chemistry, 1947),
• James B. Sumner (Chemistry, 1946),
• Artturi Virtanen (Chemistry, 1945),
• Adolf Butenandt (Chemistry, 1939),
• Corneille Jean-François Heymans (Medicine, 1938),
• William P. Murphy (Medicine, 1934),
• Hans von Euler-Chelpin (Chemistry, 1929).