Pregnant women with higher levels of fluoride in their urine may be more likely to have school-age children with certain symptoms of attention-deficit/hyperactivity disorder (ADHD), such as inattentiveness and cognitive problems, according to a new Canadian study led by researchers at the University of Toronto and York University.

The findings are published in the journal Environment International.

“Our findings are consistent with a growing body of evidence suggesting that the growing fetal nervous system may be negatively affected by higher levels of fluoride exposure,” said Dr. Morteza Bashash, the study’s lead author and researcher at the Dalla Lana School of Public Health at the University of Toronto.

The study analyzed data from 213 mother-child pairs in Mexico City who are enrolled in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project. The project recruited pregnant women from 1994 to 2005 and has continued to follow the women and their children ever since.

Tap water and dental products have been fluoridated in communities in Canada and the United States (as well as milk and table salt in some other countries) by varying amounts for more than 60 years with the goal of preventing cavities.

In recent years, fierce debate over the safety of water fluoridation — particularly for children’s developing brains — has led researchers to investigate the issue and provide evidence to inform national drinking water standards.

The research team included experts from the University of Toronto, York University, the National Institute of Public Health of Mexico, University of Michigan, Indiana University, the University of Washington and Harvard School of Public Health. The team analyzed urine samples that had been obtained from mothers during pregnancy and from their children between six and 12 years of age to reconstruct personal measures of fluoride exposure for both mother and child.

The team then looked at how urinary fluoride levels related to the child’s performance on a variety of tests and questionnaires that measure inattention and hyperactivity, and provide overall scores related to ADHD.

The researchers adjusted for other factors known to impact neurodevelopment, such as gestational age at birth, birth weight, birth order, sex, maternal marital status, smoking history, age at delivery, education, socioeconomic status and lead exposure.

“Our findings show that children with elevated prenatal exposure to fluoride were more likely to show symptoms of ADHD as reported by parents. Prenatal fluoride exposure was more strongly associated with inattentive behaviors and cognitive problems, but not with hyperactivity,” said Bashash.

This work adds to previous research the team published on this population demonstrating that higher levels of urine fluoride during pregnancy are associated with lower scores on tests of IQ and cognition in the school-age children.

ADHD is the most common psychiatric disorder diagnosed in childhood, affecting between five and nine per cent of all school-aged children.

“The symptoms of ADHD often persist into adulthood and can be impairing in daily life,” said Dr. Christine Till, associate professor of psychology at York University and co-author on the study.

“If we can understand the reasons behind this association, we can then begin to develop preventive strategies to mitigate the risk,” said Till, who is also the principal investigator of another National Institutes of Health-funded grant examining fluoride exposure in a large Canadian sample of pregnant women.

Source: University of Toronto

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*Original article online at https://psychcentral.com/news/2018/10/15/fluoride-exposure-in-pregnancy-tied-to-adhd-symptoms-in-kids/139525.html

* Following the Media: The three studies and the news articles generated here