Fluoride Action Network

Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling.

Source: JBMR Plus - 4(4):e10344. | February 20th, 2020 | Authors: Ross RD, Anderson K, Davison R, El-Masri BM, et al.
Industry type: Pharmaceuticals


The example of sodium fluoride (NaF) clearly demonstrates an instance where increasing bone mass while altering maturation can negatively affect drug efficacy. NaF was a promising osteoporosis treatment because it increased BMD.5 However, it became evident that the treated patients were at increased risk of fracture,6, 7 which was later attributed to NaF-induced aberrant mineralization.8 Had there been a preclinical model to assess the effect of NaF on maturation, it is likely that these fractures could have been avoided.


*Full study online at https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbm4.10344