latest news: Pharmaceuticals
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Fluorination via porphyrin
The proposed mechanism relies on the oxomanganese to selectively cleave C-H bonds © Science/AAAS Despite fluorine’s popularity with medicinal chemists, reliable activation of aliphatic C–H bonds for fluorination has remained tantalisingly out of reach. Now, a manganese porphyrin has been used to selectively fluorinate sp3 carbon–hydrogen bonds using silver fluoride as a source of fluorine. […]
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WMIS Launches Clinical Trials for Sodium Fluoride (F-18) for CMS
With the success of the World Molecular Imaging Society’s (WMIS) initiative in helping obtain the FDA approval for Sodium Fluoride F18 injection, WMIS is now launching critical clinical trials to secure fair and meaningful reimbursement for this procedure. Successful clinical trials for reimbursement are necessary to ensure the feasibility and market acceptance for this diagnostic […]
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Voriconazole : Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy
Full paper available online in html or pdf Abstract: Background. We describe a heart transplant patient with painful periostitis and exostoses who was receiving long-term therapy with voriconazole, which is a fluoride-containing medication. Elevated plasma and bone fluoride levels were identified. Discontinuation of voriconazole therapy led to improvement in pain and reduced fluoride and alkaline […]
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Some medicinal chemists can’t get enough fluorines in their molecules
Column: In the pipeline Some medicinal chemists can’t get enough fluorines in their molecules. Derek Lowe explains the love-hate relationship Fluorine is a nasty element. That may be an unfair judgment, but I’m prepared to defend it, at least as long as we’re talking about the zero-oxidation-state pure element. I have never used fluorine gas, […]
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Europe: SonoVue containing Sulphur hexafluoride, for use in ultrasound imaging
Excerpts: ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT SonoVue 8 microlitres / ml powder and solvent for dispersion for injection 2. QUALITATIVE AND QUANTITATIVE COMPOSITION One ml contains 8 ?l of sulphur hexafluoride microbubbles On reconstitution as directed, 1 ml of the resulting dispersion contains 8 ?l sulphur hexafluoride in […]
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Bone Fractures: Symptoms or Side Effects?
Bone fractures are often a symptom of conditions or diseases such as osteoporosis, but could also be side effects associated with certain medications. Below is a list of diseases and conditions associated with symptoms like bone fractures, as well as a list of medications related to similar side effects. We are not medical professionals, and […]
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Fluorines make hydrogen bonds
Scientists in the US have shown that fluorine compounds can form hydrogen bonds, a finding that could have implications for the pharmaceutical industry, they say Fluorine is often used in drug development as its presence in organic compounds can affect properties such as absorption, distribution and stability. However, exactly how it interacts with biological molecules […]
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New Way To Prepare Fluorinated Pharmaceuticals
A team of MIT chemists has devised a new way to add fluorine to a variety of compounds used in many drugs and agricultural chemicals, an advance that could offer more flexibility and potential cost-savings in designing new drugs. Drug developers commonly add fluorine atoms to drugs, such as the cholesterol-lowering rosuvastatin, to keep the […]
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Loans help Palm Beach County vitamin maker add 25 jobs
RIVIERA BEACH — Vitamin maker Sancilio & Co. will add 25 jobs over the next 18 months and landed loans of $350,000 each from Jupiter and Riviera Beach, the Business Development Board of Palm Beach County said Tuesday. Sancilio & Co., headed by pharmaceutical researcher Frederick Sancilio, has 25 employees. They’re divided between its headquarters […]
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New facility in Omaha, Neb., to produce fluorine-18 (F-18)
Title of press release: Cardinal Health Extends Radiopharmaceutical Manufacturing Network to Nebraska New Omaha facility to help advance the early diagnosis and treatment of disease DUBLIN, Ohio, March 16 /PRNewswire-FirstCall/ — Cardinal Health, a global provider of products and services that improve the safety and productivity of health care, today announced that it has opened […]
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