Prioritization: Chemicals for Consultation by the Carcinogen Identification Committee

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). OEHHA has screened candidate chemicals in a cancer tracking data base for evidence of cancer hazard as well as human exposure in California. The screening follows the procedure established in December 2004 and described in the OEHHA document “Process for Prioritizing Chemicals for Consideration under Proposition 65 by the State’s Qualified Experts.”

OEHHA has applied two data screens to roughly half the chemicals in a tracking database: a human data screen and an animal data screen. This screening approach was discussed at the November 17, 2007 and November 5, 2008 meetings of the Carcinogen Identification Committee (CIC). The CIC is comprised of the state’s qualified experts for carcinogenicity for implementing Proposition 65.

OEHHA subjected the chemicals passing the screens to a preliminary toxicological evaluation, as described in the 2004 OEHHA document. As a result of this preliminary evaluation, OEHHA identified the 38 chemicals listed below for possible preparation of hazard identification materials. At its next meeting – on Friday, May 29, 2009 – the CIC will provide OEHHA with advice on the prioritization of these chemicals for possible preparation of hazard identification materials. Based on the CIC’s advice, OEHHA will select chemicals for preparation of Hazard Identification Materials. These materials will be used by the CIC at future meetings to decide which chemicals to add to the Proposition 65 list. No listing decisions will be made concerning these chemicals at the May 29 meeting.

This notice marks the start of a 60-day public comment period. The comment period ends May 5, 2009. Interested parties may provide comment on the extent of the scientific evidence pertaining to the selection of any of these chemicals for possible preparation of hazard identification materials. OEHHA will forward the comments to the CIC members prior to their meeting.

The CIC meeting will be held in the Sierra Hearing Room of the California Environmental Protection Agency headquarters building located at 1001 I Street, Sacramento. The meeting will begin at 10:00 a.m. and will last until all business is conducted. The agenda for the meeting will be provided in a future public notice published in advance of the meeting.

  • 2-Amino-5-nitrothiazole
  • 11-Aminoundecanoic acid
  • Amphetamine and its salts
  • Anthanthrene
  • Aspartame
  • Benoxacor
  • 2-Chloro-1,1,1-trifluoroethane
  • D & C Yellow #11
  • 1,3-Dichloro-2-propanol
  • Dicofol
  • Diethanolamine (DEA)
  • N,N-Diethylthiourea
  • Diisononyl phthalate (DINP)
  • 2,6-Dimethyl-n-nitrosomorpholine
  • 1,3-Dinitropyrene
  • Ethynodiol diacetate
  • Fluoride and its salts
  • Haloperidol
  • Hydroquinone
  • Methoxychlor
  • Methyl ethyl ketoxime
  • Molybdenum trioxide
  • 3-Monochloropropane-1,2-diol (3-MCPD)
  • 3-Nitrofluoranthene
  • Nitrofurantoin
  • N-Nitrosoanabasine
  • N-Nitrosohexamethyleneimine
  • 5-Nitro-o-toluidine
  • Perfluorooctanoic acid and its salts and transformation and degradation precursors
  • Permethrin
  • Rock wool
  • Tetrachlorvinphos
  • Thiamethoxam
  • Triamterene
  • Triclosan
  • Tris(1,3-dichloro-2-propyl) phosphate
  • Triethanolamine (TEA)
  • Vinylidene chloride

Copies of the summaries of available scientific information on the chemicals and related attachments will be available on OEHHA’s web site above on March 9th, or may be requested by calling (916) 445-6900.* It is requested, but not required, that written comments and supporting documentation be transmitted via email addressed to

Comments may also be delivered in triplicate in person or by courier to:

Cynthia Oshita
Office of Environmental Health Hazard Assessment
Proposition 65 Implementation
P.O. Box 4010 1001 I Street, 19th floor
Sacramento, California 95812-4010
FAX (916) 323-8803

In order to be considered by the CIC Members, written comments must be received at OEHHA by 5:00 p.m. on Tuesday, May 5, 2009.

*NOTE: Copies will be provided by OEHHA in the format available. Hard copies are subject to our photocopying fee of $0.25 per page, minimum $2.50.


Proposition 65, the Safe Drinking Water and Toxic Enforcement Act of 1986, was enacted as a ballot initiative in November 1986. The Proposition was intended by its authors to protect California citizens and the State’s drinking water sources from chemicals known to cause cancer, birth defects or other reproductive harm, and to inform citizens about exposures to such chemicals.