Fluoride Action Network

NTP and TSCA Trial: Comparison of Human Studies cited by each

The following are the majority of studies introduced into the TSCA trial or cited by the National Toxicology Program (NTP). Eventually, all the human studies introduced into the trial or into NTP’s documents on fluoride’s neurotoxicity will be listed here.

Codes

Date: Published in English

NTP-1 : Human Studies that were used in the National Toxicology Program 2019 draft Systematic Reviews of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.

NTP-2 : Human Studies identified but not used in the NTP’s 2019 draft report (see above).

NTP-3 : Human Studies that were used in the National Toxicology Program 2020 draft Systematic Reviews of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.

TSCA-1 : Human Studies submitted to US Environmental Protection Agency on November 22, 2016, in Citizens’ Petition under Section 21 of the Toxic Substances Control Act (TSCA) to ban the addition of fluoridation chemicals to drinking water due to fluoride’s neurotoxicity.

TSCA-2 : Human Studies submitted into the TSCA record after Nov 22, 2016.

Comparison of Human Studies cited by the NTP and by Petitioners in the TSCA Trial

Date Author Title Publication Topic Source
2020 Cui Y, Yu J, Zhang B, Guo B, Gao T, Liu H. The relationships between thyroid-stimulating hormone and/or dopamine levels in peripheral blood and IQ in children with different urinary iodine concentrations. Neurosci Lett IQ NTP-3
2020 Till C, Green R, Flora D, Hornung R, Martinez-Mier EA, Blazer M, Farmus L, Ayotte P, Muckle G, Lanphear B. Fluoride exposure from infant formula and child IQ in a Canadian birth cohort. Environment International

IQ lowered

NTP-3
TSCA-2
2020 Wang A, Duan L, Huang H, Ma J, Zhang Y, Ma Q, Guo Y, Li Z, Cheng X, Zhu J, Zhou G, Ba Y. Association between fluoride exposure and behavioural outcomes of school-age children: A pilot study in China. Int J Environ
Health Res
Behavioural outcomes NTP-3
2020 Wang M, Liu L, Li H, Li Y, Liu H, Hou C, Zeng Q, Li P, Zhao Q, Dong L, Zhou G, Yu X, Liu L, Guan Q, Zhang S, Wang A. Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children. Environment International

IQ lowered

NTP-3
2020 Zhao Q, Tian Z, Zhou G, Niu Q, Chen J, Li P, Dong L, Xia T, Zhang S, Wang A. SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride. Theranostics Cellular
effects in
neuro-
developmnt
NTP-3
2019 Green R, Lanphear B, Hornung R, Flora D, Martinez-Mier EA, Neufeld R, Ayotte P, Muckle G, Till C. 2019 Association between maternal fluoride exposure during pregnancy and IQ scores in offspring in Canada. JAMA
Pediatics

IQ lowered

Mother-
Offspring

NTP-1
NTP-3
TSCA-2
2019 Lu F, Zhang Y, Trivedi A, Jiang X, Chandra D, Zheng J, Nakano Y, Uyghurturk DA, Jalai R, Guner S, Mentes A, DenBesten PK. Fluoride related changes in behavioral outcomes may relate to increased serotonin. Physiol
Behav
Behaviour NTP-1
NTP-3
2019 Riddell JK, Malin AJ, Flora D, McCague H, Till C. Association of water fluoride and urinary fluoride concentrations with attention deficit hyperactivity disorder in Canadian youth. Environment International ADHD NTP-3
2019 Russ TC, Killin LOJ, Hannah J, Batty GD, Deary IJ, Starr JM. 2019 Aluminium and fluoride in drinking water in relation to later dementia risk. Brit J
Psychol
Dementia NTP-1
NTP-3
2019 Soto-Barreras U, Escalante-Villalobos KY, Holguin-Loya B, Perez-Aguirre B, Nevarez-Rascon A, Martinez-Martinez RE, Loyola-Rodriguez JP. Effect of fluoride in drinking water on dental caries and IQ in children. Fluoride IQ
no effect
NTP-3
2019 Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, Dong L, Xu C, Tian Z, Luo C, Liu L, Zhang S, Wang A. Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: Mechanisms of action in vitro and associations with cognition in rats and children. Arch
Toxicol
Neuro-
toxicity
NTP-1
NTP-3
2018 Bashash M, Marchand M, Hu H, Till C, Martinez-Mier EA, Sanchez BN, Basu N, Peterson KE, Green R, Schnaas L, Mercado-Garcia A, Hernandez-Avila M, Tellez-Rojo MM. Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years of age in Mexico City. Environment International

ADHD

Mother-
Offspring

NTP-1
NTP-3
TSCA-2
2018 Bellinger DC. Environmental chemical exposures and neurodevelopmental impairments in children. Pediatric Medicine Neuro-
develop-
mental
TSCA-2
2018 Cui Y, Zhang B, Ma J, Wang Y, Zhao L, Hou C, Yu J, Zhao Y, Zhang Z, Nie J, Gao T, Zhou G, Liu H. Dopamine receptor D2 gene polymorphism, urine fluoride, and intelligence impairment of children in China: A school-based cross-sectional study. Ecotox
& Env
Safety

IQ
lowered

NTP-1
NTP-3
TSCA-2
2018 Duan Q, Jiao J, Chen X, Wang X. Association between water fluoride and the level of children’s intelligence: A dose-response meta-analysis. Public Health IQ NTP-3
2018 El Sehmawy AAEW, Hammouda SM, Ibrahim GE, Barghash SS, Elamir RY. Relationship between Drinking Water Fluoride and Intelligence Quotient in Egyptian School Children. Occupational Medicine & Health Affairs

IQ
Lowered

TSCA-2
2018 Goschorska M, Baranowska-Bosiacka I, Gutowska I, Metryka E, Skórka-Majewicz M, Chlubek D. Potential Role of Fluoride in the Etiopathogenesis of Alzheimer’s Disease. Intl
J of Mol
Sc
Alzheimer’s TSCA-2
2018 Harriehausen CX, Dosani FZ, Chiquet BT, Barratt MS, Quock RL. Fluoride Intake of Infants from Formula. J of
Clinical
Pediatric Dentistry
Formula-
fed infant
TSCA-2
2018 Induswe B, Opinya G, Khasakhala LI, Owino R. The Auditory Working Memory of 13-15-Year-Old Adolescents Using Water with Varying Fluoride Concentrations from Selected Public Primary Schools in North Kajiado Sub County. American Journal of Medicine and Medical Sciences

IQ
Lowered

TSCA-2
2018 Kheradpisheh Z, Mahvi AH, Mirzaei M, Mokhtari M, Azizi R, Fallahzadeh H, Ehrampoush MH. Correlation between drinking water fluoride and TSH hormone by ANNs and ANFIS. J Environ
Health Sci
Eng
Thyroid NTP-1
NTP-3
2018 Kheradpisheh Z, Mirzaei M, Mahvi AH, Mokhtari M, Azizi R, Fallahzadeh H, Ehrampoush MH. Impact of drinking water fluoride on human thyroid hormones: A case-control study. Sci Rep Thyroid NTP-1
NTP-3
2018 Khandare AL, Validandi V, Gourineni SR, Gopalan V, Nagalla B. Dose-dependent effect of fluoride on clinical and subclinical indices of fluorosis in school going children and its mitigation by supply of safe drinking water for 5 years: An Indian study. Environ
Monit
Assess
*Classic fluorosis NTP-1
NTP-3
2018 Kumar V, Chahar P, Kajjari S, Rahman F, Bansal DK, Kapadia JM. 2018 Fluoride, thyroid hormone derangements and its correlation with tooth eruption pattern among the pediatric population from endemic and non-endemic fluorosis areas. J Contemp
Dent Pract
Thyroid NTP-1
NTP-3
2018 Malin AJ, Riddell J, McCague H, Till C. Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status. Envir
Intl
Thyroid NTP-1
NTP-3
TSCA-2
2018 Mustafa DE, Younis UM, Elhag SAA. The relationship between the fluoride levels in drinking water and the schooling performance of children in rural areas of Khartoum State, Sudan. Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-2
2018 Pang H, Yu L, Lai X, Chen Q. Relation Between Intelligence and COMT Gene Polymorphism in Children Aged 8-12 in the Endemic Fluorosis Area and Non-Endemic Fluorosis Area. Chinese
J of Control
of Endemic Diseases
Translated
by FAN

IQ
lowered

TSCA-2
2018 Rathore S, Meena C, Gonmei Z, Dwivedi S, Toteja GS, Bala K. Study of excess fluoride ingestion and thyroid hormone derangement in relation with different fluoride levels in drinking water among children of Jodhpur District, Rajasthan, India. Asian J
Microbiol Biotechnol Environ Sci
Thyroid NTP-2
2018 Till C, Green R, Grundy JG, Hornung R, Neufeld R, Martinez-Mier EA, Ayotte P, Muckle G, Lanphear B. Community water fluoridation and urinary fluoride concentrations in a national sample of pregnant women in  Canada. Env Health Persp Fluoride
Urine levels
NTP-3
2018 Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, Cui Y, Zhao L, Li P, Zhou Z, Pang S, Tang S, Tian K, Zhao Q, Dong L, Xu C, Zhang X, Zhang S, Liu L, Wang A. Threshold effects of moderately excessive fluoride exposure on children’s health: A potential association between dental fluorosis and loss of excellent intelligence. Environment International

IQ
lowered

NTP-1
NTP-3
TSCA-2
2017 Barberio AM, Hosein FS, Quinonez C, McLaren L. Fluoride exposure and indicators of thyroid functioning in the Canadian population: Implications for community water fluoridation. J Epidemiol
Community Health
Thyroid NTP-1
NTP-3
2017 Barberio AM, Hosein FS, Quinonez C, McLaren L. Fluoride exposure and reported learning disability diagnosis among Canadian children: Implications for community water fluoridation. Can J Public Health Learning disability NTP-1
NTP-3
TSCA-2
2017 Bashash M, Thomas D, Hu H, Martinez-Mier EA, Sanchez BN, Basu N, Peterson KE, Ettinger AS, Wright R, Zhang Z, Liu Y, Schnaas L, Mercado-Garcia A, Tellez-Rojo MM, Hernandez-Avila M. Prenatal fluoride exposure and cognitive outcomes in children at 4 and 6-12 years of age in Mexico. Environmental Health Perspectives

IQ
lowered

Mother-Offspring

NTP-1
NTP-3
TSCA-2
2017 Chang A, Shi Y, Sun H, Zhang L. Analysis on the Effect of Coal-Burning Fluorosis on the Physical Development and Intelligence Development of Newborns Delivered by Pregnant Women with Coal-Burning Fluorosis. Chinese Journal of Control of Endemic Diseases

IQ
Lowered

Mother-Offspring

TSCA-2
2017 Gais S, Schonauer M. Untangling a cholinergic pathway from wakefulness to memory. Neuron Acetylcholine (ACh),
Learning
Memory
Aa
2017 Jin T, Wang Z, Wei Y, Wu Y, Han T, Zhang H. Investigation of Intelligence Levels of Children of 8 to 12 Years of Age in Coal Burning-Related Endemic Fluorosis Areas.

Journal of Environment and Health

Translated
by FAN

IQ
Lowered

TSCA-2
2017 Khandare  AL, Gourineni SR, Validandi V. Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride- affected hilly areas of Doda District, Jammu and Kashmir, India. Environ
Monit
Assess
Thyroid NTP-1
NTP-3
2017 Ma Q, Huang H, Sun L, Zhou T, Zhu J, Cheng X, Duan L, Li Z, Cui L, Ba Y Gene-environment interaction: Does fluoride influence the reproductive hormones in male farmers modified by ER? gene polymorphisms? Chemosphere Reprod-
tive
Genes
NTP-3
2017 Pramanik S, Saha D. The genetic influence in fluorosis. Environ
Toxicol Pharmacol
.
*Classic fluorosis
Genetics
TSCA-2
2017 Razdan P, Patthi B, Kumar JK, Agnihotri N, Chaudhari P, Prasad M. Effect of fluoride concentration in drinking water on intelligence quotient of 12-14-year-old children in Mathura District: A cross- sectional study. J Int Soc
Prev
Community
Dent.

IQ
lowered

NTP-1
NTP-3
TSCA-2
2017 Valdez Jimenez L, Lopez Guzman OD, Cervantes Flores M, Costilla-Salazar R, Calderon Hernandez J, Alcaraz Contreras Y, Rocha-Amador DO. In utero exposure to fluoride and cognitive development delay in infants. Neuro
-toxicology

IQ
lowered

Mother-Offspring

NTP-1
NTP-3
TSCA-2
2017

Zigu Z, Xiaoyu W, Weiwei N, Qiuxia L, Rui Z, Wei O.

[Wrong authors referenced: Zhang Z et al.]

Effects of calcium on drinking fluorosis-induced hippocampal synaptic plasticity impairment in the offspring of rats. Transl
Neurosci
Hippo-
campus
TSCA-2
2016 Aravind A, Dhanya RS, Narayan A, Sam G, Adarsh VJ, Kiran M. Effect of fluoridated water on intelligence in 10-12-year-old school children. J Int Soc
Prev
Community
Dent.

IQ
lowered

NTP-1
NTP-3
2016 Centers for Disease Control and Prevention Water Fluoridation Data & Statistics. CDC
Govt
Report
Statistics TSCA-2
2016 Cheng H, Lynn R. The adverse effect of fluoride on children’s intelligence:  A systematic review. Mankind
Quarterly
IQ
Syste-
matic
review
TSCA-2
2016 Das K, Mondal NK. Dental fluorosis and urinary fluoride concentration as a reflection of fluoride exposure and its impact on IQ level and BMI of children of Laxmisagar, Simlapal Block of Bankura District, W.B., India. Environ
Monit
Assess.

IQ
lowered

 

NTP-1
NTP-3
TSCA-1
2016 Li  M, Gao Y, Cui J, Li Y, Li B, Liu Y, Sun J, Liu X, Liu H, Zhao L, Sun D. Cognitive impairment and risk factors in elderly people living in fluorosis areas in China. Biol Trace
Elem Res
Cognitive
-elderly
NTP-1
NTP-3
TSCA-1
2016 Mondal D, Dutta G, Gupta S. Inferring the fluoride hydrogeochemistry and effect of consuming fluoride-contaminated drinking water on human health in some endemic areas of Birbhum District, West Bengal. Environ
Geochem
Health 

IQ
lowered

NTP-1
NTP-3
TSCA-1
2016 Savchenkov MF, Efimova NV, Manueva RS, Nikolaeva LA, Shin NS. [Thyroid gland pathology in children population exposed to the combination of iodine deficiency and fluoride pollution of environment]. Gig Sanit Thyroid NTP-2
2015 Broadbent JM, Thomson WM, Moffitt TE, Poulton R. Community water fluoridation and intelligence response. Am J Pub
Health
IQ
no effect
NTP-1
NTP-3
TSCA-1
2015 Choi AL, Zhang Y, Sun G, Bellinger DC, Wang K, Yang XJ, Li JS, Zheng Q, Fu Y, Grandjean P. Association of lifetime exposure to fluoride and cognitive functions in Chinese children: A pilot study. Neurotoxicol Teratol

IQ
lowered

NTP-1
NTP-3
TSCA-1
2015 Khan SA, Singh RK, Navit S, Chadha D, Johri N, Navit P, Sharma A, Bahuguna R. Relationship between dental fluorosis and intelligence quotient of school going children in and around Lucknow District: A cross-sectional study. J Clin
Diagn Res

IQ
lowered

NTP-1
NTP-3
TSCA-1
2015 Kundu H, Basavaraj P, Singla A, Gupta R, Singh K, Jain S. Effect of fluoride in drinking water on children’s intelligence in high and low fluoride areas of Delhi. J Indian
Assoc Pub
Health Dent

IQ
lowered

NTP-1
NTP-3
TSCA-1
2015 Malin AJ, Till C. Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: An ecological association. Environ
Health
ADHD NTP-1
NTP-3
TSCA-1
2015 Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water. Epidemiol Community Health Thyroid NTP-1
NTP-3
TSCA-1
2015 Sebastian ST, Sunitha S.

A cross-sectional study to assess the intelligence quotient (IQ) of school going children aged 10-12 years in villages of Mys

ore District, India with different fluoride levels.

J Indian Soc Pedod Prev
Dent.

IQ
lowered

NTP-1
NTP-3
TSCA-1
2015 Zhang S, Zhang X, Liu H, Qu W, Guan Z, Zeng Q, Jiang C, Gao H, Zhang C, Lei R, Xia T, Wang Z, Yang L, Chen Y, Wu X, Cui Y, Yu L, Wang A. Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children’s intelligence in endemic fluorosis area in Tianjin, China. Toxicol
Sci

IQ
lowered

NTP-1
NTP-3
TSCA-1
2015 Zhang P, Cheng L. Effect of coal-burning endemic fluorosis on children’s physical development and intellectual level.

Chinese Journal of Control of Endemic Diseases

Translated
by FAN

IQ
lowered

TSCA-1
2014 Asawa K, Pujara P, Thakkar JP, Pandya BG, Sharma AR, Pareek S, Tak A, Tak M, Maniar R.

Assessment of intelligence quotient among schoolchildren of fishermen community of Kutch, Gujarat, India.

Note: This study is similar to one by Nagarajappa et al.  (2013) below.

International Maritime Health

IQ
lowered

TSCA-1
2014 Bai A, Li Y, Fan Z, Li X, Li P. [Intelligence and growth development of children in coal-burning-borne arsenism and fluorosis areas: An investigation study].
Also titled:
Investigation and analysis of the development of
intelligence levels and growth of children in areas suffering fluorine and arsenic toxicity
from pollution from burning coal.
Chinese J
Endemiology
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2014 Grandjean P, Landrigan PJ. Neurobehavioural effects of developmental toxicity. Lancet
Neurology
Develop-mental
toxicity
TSCA-1
2014 Karimzade S, Aghaei M, Mahvi AH. Investigation of intelligence quotient in 9-12 year-old children exposed to high- and low-drinking water fluoride in West Azerbaijan Province, Iran. Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
2014 Karimzade S, Aghaei M, Mahvi AH. Letter to the Editor: IQ of 9-12 year-old children in high and low-drinking water fluoride areas in West Axerbaijan Province, Iran: Further information on the two villages in the study and the confounding factors considered. Fluoride

IQ
lowered

TSCA-1
2014 Singh N, Verma KG, Verma P, Sidhu GK, Sachdeva S. A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from endemic and non-endemic fluorosis areas. Springerplus Thyroid NTP-1
NTP-3
2014 Singh VP, Chauhan DS, Tripathi S, Gaur V, Tomar A, Tiwari M. Acetylcholinesterase activity in fluorosis adversely affects mental well-being: an experimental study in rural Rajasthan. European Academic
Journal
AChE
activity
TSCA-1
2014 Wei  N, Li Y, Deng J, Xu S, Guan Z. [The effects of comprehensive control measures on intelligence of school-age children in coal-burning-borne endemic fluorosis areas].

Chinese J Endemiology

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2013 Cheng H, Lynn R, The adverse effect of fluoride on children’s intelligence: A systematic review. Mankind
Quarterly
IQ
Syste-
matic
review
TSCA-2
2013 Choi AL, Grandjean P, Sun G, Zhang Y. Developmental Fluoride Neurotoxicity: Choi et al. Respond. Environmental Health Perspectives IQ
Response
to review
NTP-3
TSCA-2
2013 Dai HX, Zeng P, Wang KY, Zhang XG, Ma ZJ, Zhou YG, Fan ZX, Guo SH. [Analysis of a survey results of patients with suspected high iodine goiter in Liuji Town Fuping County of Shaanxi Province.] Chinese J
Endemiology
Thyroid
Goiter
No
Abstract
NTP-2
2013 Kutlucan A, Kale Koroglu B, Numan Tamer M, Aydin Y, Baltaci D, Akdogan M, Ozturk M, Vural H, Ermis F. The investigation of effects of fluorosis on thyroid volume in school-age children. Med Glas Thyroid NTP-2
2013 Nagarajappa R, Pujara P, Sharda AJ, Asawa K, Tak M, Aapaliya P, Bhanushali N.

Comparative assessment of intelligence quotient among children living in high and low fluoride areas of Kutch, India: A pilot study.

Note: This study is similar to one by Asawa et al.  (2014) above.

Iranian J
Pub Health

IQ
lowered

NTP-1
NTP-3
TSCA-1
2013 Singh VP, Singh C, Sandeep T, Sandeep K, Vikas G, Mukesh T, Anurag T. A correlation between serum vitamin, acetylcholinesterase activity and IQ in children with excessive endemic fluoride exposure in Rajasthan, India. Int Res J
Med Sci

IQ
lowered

NTP-1
NTP-3
TSCA-1
2013 Arbuckle TE, Fraser WD, Fisher M, Davis K, Liang CL, et al. (53 authors in all)
Cohort profile: The maternal-infant research on environmental chemicals research platform. Paediatr Perinat Epidemiol  MIREC
Cohort
Study
NTP-3
2013 Centers for Disease Control and Prevention (CDC) Community water fluoridation: Fluoridation statistics. CDC Fluorida-
tion
stats
NTP-3
2013 Xiang Q, Wang Y, Yang M, Zhang M, Xu Y. Level of fluoride and arsenic in household shallow well water in Wamiao and Xinhuai villages in Jiangsu Province, China. Fluoride Background
to Xiang’s
2011
IQ study
NTP-3
TSCA-1
2013 Yasmin S, Ranjan S, D’Souza D. Effect of excess fluoride ingestion on human thyroid function in Gaya Region, Bihar, India. Toxicol
Environ
Chem
Thyroid NTP-1
NTP-3
2013 Zhang T, Shan KR, Tu X, He Y, Pei JJ, Guan ZZ. Myeloperoxidase activity and its corresponding mRNA expression as well as gene polymorphism in the population living in the coal-burning endemic fluorosis area in Guizhou of China. Biol Trace
Elem Res
Genes TSCA-2
2012 Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: a systematic review and meta-analysis. Environmental Health Perspectives IQ
Syste-
matic
review
NTP-1
NTP-3
TSCA-1
2012 Hosur MB, Puranik RS, Vanaki S, Puranik SR. Study of thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in subjects with dental fluorosis. Eur J Dent Thyroid NTP-1
NTP-3
2012 Saxena S, Sahay A, Goel P. Effect of fluoride exposure on the intelligence of school children in Madhya Pradesh, India. J Neurosci
Rural
Pract.

IQ
lowered

NTP-1
NTP-3
TSCA-1
2012 Seraj B, Shahrabi M, Shadfar M, Ahmadi R, Fallahzadeh M, Eslamlu HF, Kharazifard MJ. Effect of high water fluoride concentration on the intellectual development of children in Makoo, Iran. J Dent,
Tehran U
Med Sci

IQ
lowered

NTP-1
NTP-3
TSCA-1
2012 Trivedi M, Sangai N, Patel R, Payak M, Vyas S. Assessment of groundwater quality with special reference to fluoride and its impact on IQ of schoolchildren in six villages of the Mundra Region, Kachchh, Gujurat, India. Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
2012 Wang QJ, Gao MX, Zhang MF, Yang Ml, Xiang, QY.

Study on the correlation between daily total fluoride intake and children’s intelligence quotient.

Note: This was further study on the Xiang (2003) IQ study below.

J Southeast
Univ
(Med Sci Edi)
Translated
by FAN

IQ
lowered

NTP-3
TSCA-1
2012 Zhou T, Duan LJ, Ding Z, Yang RP, Li SH, Xi Y, Cheng XM, Hou JX, Wen SB, Chen J, Cui LX, Ba Y. Environmental fluoride exposure and reproductive hormones in male living in endemic fluorosis villages in China. Life Sci J Repro-
ductive
toxicity
NTP-3
2011 Ba Y, Zhang H, Wang G, Wen S, Yang Y, Zhu J, Ren L, Yang R, Zhu C, Li H, Cheng X, Cui L. Association of dental fluorosis with polymorphisms of estrogen receptor gene in Chinese children. Biol Trace
Elem Res
Genes &
dental
fluorosis
TSCA-1
2011 Ding Y, Sun H, Han H, Wang W, Ji X, Liu X, Sun D. The relationships  between low  levels of urine fluoride on children’s intelligence, dental fluorosis in endemic fluorosis areas in Hulunbuir, Inner Mongolia, China. J Hazard
Mater

IQ
lowered

NTP-1
NTP-3
TSCA-1
2011 Kang JQ, Cheng YB, Wu KG. [Effects of fluoride and arsenic in drinking water on children’s intelligence].
Title is slightly different between NTP and TSCA.
Chinese J
Sch Health
IQ
no effect
NTP-3
TSCA-1
2011 Eswar P, Nagesh L, Devaraj CG. Intelligent quotients of 12-14 year old school children in a high and low fluoride village in India. Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
2011 Poureslami HR, Horri A, Garrusi B. A comparative study of the IQ of children age 7-9 in a high and a low fluoride water city in Iran.
NOTE: This is the same study  published in  Journal of Dentistry and Oral Hygiene in 2011.
Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
2011 Shivaprakash PK, Ohri K, Noorani H. Relation between dental fluorosis and intelligence quotient in school children of Bagalkot District. J Indian Soc Pedod Prev
Dent

IQ
lowered

NTP-1
NTP-3
TSCA-1
2011 Xiang Q, Liang Y, Chen B, Chen L. Analysis of children’s serum fluoride levels in relation to intelligence scores in a high and low fluoride water village in China. Fluoride IQ NTP-1
NTP-3
TSCA-1
2011 Yazdi SM, Sharifian A, Dehghani-Beshne M, Momeni VR, Aminian O. Effects of fluroide on psychomotor performance and memory of aluminum potroom workers. Fluoride Memory
Psycho-
motor
NTP-1
NTP-3
TSCA-1
2010 Environmental Protection Agency Fluoride: Exposure and Relative Source Contribution Analysis. EPA-820-R-10-015. EPA
Office of
Water
Govt
report
NTP-3
TSCA-2
2010 Environmental Protection Agency Fluoride: Dose-Response Analysis For Non-cancer Effects.  EPA-820-R-10-019. EPA
Office of
Water
Govt
report
TSCA-2
2010 Environmental Protection Agency

Comment-Response Summary Report for the Peer Review of the Fluoride: Dose-Response Analysis for Non-Cancer Effects Document

EPA-820-R-10-016.

EPA
Office of
Water
Govt
report
TSCA-2
2010 He MX, Zhang CN [Investigation of children’s intelligence quotient and dental fluorosis in drinking water-type of endemic fluorosis area in Pucheng County, Shaanxi Province before and after drinking water change]. Chinese J
Endemiology
IQ
no effect
NTP-1
NTP-3
TSCA-1
2010 Li X, Hou G, Yu B, Yuan C, Liu Y, L Z. Investigation and analysis of children’s intelligence and dental fluorosis in high fluoride area. Chinese J
Pest Control
Translated
by FAN
IQ
no effect
NTP-1
NTP-3
TSCA-1
2010 McGlashan N, Chelkowska E, Sasananan S. A survey of goiter morbidity in Ban Mae Toen, northwest Thailand. Southeast
Asian J Trop
Med Public
Health
Goiter NTP-2
2010 U.S. Environmental Protection Agency Fluoride: Exposure and relative source contribution analysis. EPA # 820-R-10-015. Office of Water
EPA
Exposure
Sources
NTP-3
2010 Villa A, Anabalon M, Zohouri V, Maguire A, Franco AM, Rugg-Gunn A. Relationships between fluoride intake, urinary fluoride excretion and fluoride retention in children and adults: An analysis of available data. Caries
Research
Urinary
fluoride
NTP-3
2009 Li F, Chen X, Huang R, Xie Y. The impact of endemic fluorosis caused by the burning of coal on the development of intelligence in children. J Envir
Health
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2009 Rocha-Amador D, Navarro M, Trejo-Acevedo A, Carrizales L, Perez-Maldonado I, Diaz-Barriga F, Calderon J. Use of the Rey-Osterrieth Complex Figure Test for neurotoxicity evaluation of mixtures in children. Neurotox
30
Neuro-
toxicity
NTP-1
NTP-3
TSCA-1
2009 Sharma JD, Sohu D, Jain P. Prevalence of neurological manifestations in a human population exposed to fluoride in drinking water. Fluoride Neuro-
logical
NTP-1
NTP-3
TSCA-1
2009 Sudhir KM, Chandu GN, Prashant GM, Subba Reddy VV. Effect of fluoride exposure on intelligence quotient (IQ) among 13-15 year old school children of known endemic area of fluorosis, Nalgonda District, Andhra Pradesh. J Indian
Assoc
Public
Health
Dentistry

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Chen YX, Han FL, Zhoua ZL, Zhang HQ, Jiao XS, Zhang SC, Huang MC, Chang TQ, Dong YF.

Research on the intellectual development of children in high fluoride areas.

First published in Chinese in 1991

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Du L, Wan C, Cao X, Liu J. The effect of fluorine on the developing human brain.

Fluoride

Translated
by FAN

Fetal
brain
NTP-1
NTP-3
TSCA-1
2008 Guo XC, Wang RY, Cheng CF, Wei WS, Tang LM, Wang QS, Tang DX, Liu GW, He GD, Li SL.

A preliminary investigation of the IQs of 7-13 year-old children from an area with coal burning- related fluoride poisoning.

First published in Chinese in 1991

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Guo ZY, He YH, Zhu QX. Research on the neurobehavioral function of workers occupationally exposed to fluoride.

Fluoride

Translated
by FAN

Neuro-
behavior
NTP-1
NTP-3
TSCA-1
2008 He H, Cheng ZS, Liu WQ. Effects of fluorine on the human fetus.

Fluoride

Translated
by FAN

Fetal
brain
NTP-1
TSCA-1
2008 Hong FG, Cao YX, Yang D, Wang H.

Research on the effects of fluoride on child intellectual development under different environmental conditions.

First published in Chinese in 2001

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Huang H, Ba Y, Cui L, Cheng X, Zhu J, Zhang Y, Yan P, Zhu C, Kilfoy B, Zhang Y. COL1A2 gene polymorphisms (Pvu II and Rsa I), serum calciotropic hormone levels, and dental fluorosis. Community
Dent Oral Epidemiol
Genetics
Dental
fluorosis
TSCA-1
2008 Li J, Yao L, Shao QL, Wu CY. Effects of high fluoride level on neonatal neurobehavioral development.

Fluoride

Translated
by FAN

Neuro-behavioral

Mother-Offspring

NTP-1
NTP-3
TSCA-1
2008 Li Y, Li X, Wei S.

Effects of high fluoride intake on child mental work capacity: Preliminary investigation into the mechanisms involved.

First published in Chinese in 1996

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Li  YP, Jing XY, Chen D, Lin L, Wang ZJ.

Effects of endemic fluoride poisoning on the intellectual development of children in Baotou.

First published in Chinese in 2003

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Liu S Lu Y Sun Z, Wu LLu W Wang X, Yan S.

Report on the intellectual ability of children living in high-fluoride water areas.

Note: This is a duplicate study of Lu et al. (2000).

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
2008 Qin LS, Huo SY, Chen RL, Chang YZ, Zhao MY.

Using the Raven’s Standard Progressive Matrices to determine the effects of the level of fluoride in drinking water on the intellectual ability of school-age children.

First published in Chinese in 1990

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
NRC2006
2008 Ratan SK, Rattan KN, Pandey RM, Singhal S, Kharab S, Bala M, Singh V, Jhanwar A. Evaluation of the levels of folate, vitamin B12, homocysteine and fluoride in the parents and the affected neonates with neural tube defect and their matched controls. Pediatr Surg Int Mother-Offspring NTP-1
2008 Ren D, Li K, Liu D.

A  study of   the intellectual ability of   8-14  year-old  children in high fluoride, low iodine areas.

First published in Chinese in 1989

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Wang G, Yang D, Jia F, Wang H.

A study of the IQ levels of four- to seven-year-old children in high fluoride areas.

First published in Chinese in 1996

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Wang SY, Zhang HX, Fan W, Fang SJ, Kang PP, Chen XG, Yu MJ.

The effects of endemic fluoride poisoning caused by coal burning on the physical development and intelligence of children.

First published in Chinese in 2005

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Yang Y, Wang X, Guo X, Hu P.

The effects of high levels of fluoride and iodine on child intellectual ability and the metabolism of fluoride and iodine.

First published in Chinese in 1994

Fluoride

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2008 Yu YN, Yang WX, Dong Z, Wan CW, Zhang JT, Liu JL, Xiao KQ, Huang YS, Lu BF. Neurotransmitter and receptor changes in the brains of fetuses from areas of endemic fluorosis.

Fluoride

Translated
by FAN

Fetal
brain
NTP-1
NTP-3
TSCA-1
2007 Fan Z, Dai H, Bai A, Li P, Li T, Li G. The effect of high fluoride exposure on the level of intelligence in children. J
Environ
Health

IQ
lowered

NTP-1
NTP-3
TSCA-1
2007 Rocha-Amador D, Navarro ME, Carrizales L, Morales R, Calderon J. Decreased intelligence in children and exposure to fluoride and arsenic in drinking water. Cadernos
de Saude
Publica 

IQ
lowered

NTP-1
NTP-3
TSCA-1
2007 Tripathi P, Sultana N. Fluoride content of groundwater and prevalence of dental, skeletal and neurological stage of fluorosis in Tehsil Purwa of Unnao. Indian Journal of Environmental Protection *Classic fluorosis NTP-1
2007 Trivedi MH, Verma RJ, Chinoy NJ, Patel RS, Sathawara NG. Effect of high fluoride water on intelligence of school children in India. Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
2007 Wang SX, Wang ZH, Cheng XT, Li J, Sang ZP, Zhang XD, Han LL, Qiao XY, Wu ZM, Wang ZQ. Arsenic and fluoride exposure in drinking water: Children’s IQ and growth in Shanyin County, Shanxi Province, China. Environmental Health Perspectives

IQ
lowered

NTP-1
NTP-3
TSCA-1
2006 Bassin EB, Wypij D, Davis RB, Mittleman MA. Age-specific fluoride exposure in drinking water and osteosarcoma (United States). Cancer
Causes
Control
Age-
specific exposure
Bone
TSCA-2
2006 Seraj B, Shahrabi M, Falahzade M, Falahzade F, Akhondi N. Effect of high fluoride concentration in drinking water on children’s intelligence. J
Dental
Medicine

IQ
lowered

NTP-1
NTP-3
TSCA-1
2006 Wang Z, Wang S, Zhang X, Li J, Zheng X, Hu C. Investigation of children’s growth and development under long-term fluoride exposure. Chin J
Control
Endem Dis
Translated
by FAN
*Classic fluorosis NTP-1
NTP-3
TSCA-1
2006 Zohouri FV, Swinbank CM, Maguire A, Moynihan PJ. Is the fluoride/creatinine ratio of a spot urine sample indicative of 24-h urinary fluoride? Community
Dent Oral
Epidemiol
Urinary
fluoride
NTP-3
2005 Gas’kov AI, Savchenkov MF, Iushkov NN. [The specific features of the development of iodine deficiencies in children living under environmental pollution with fluorine compounds]. Gig Sanit Iodine deficiency NTP-2
2005 Jones S, Burt BA, Petersen PE, Lennon MA. The effective use of fluorides in public health. Bull World
Health
NTP-3
2005 Susheela AK, Bhatnagar M, Vig K, Mondal NK. Excess fluoride ingestion and thyroid hormone derangements in children living in Delhi, India. Fluoride Thyroid NTP-1
NTP-3
TSCA-2
2005 Wang SX, Wang ZH, Cheng XT, Li J, Sang ZP, Zhang XD, Han LL, Qiao XY, Wu ZM, Wang ZQ. [Investigation and evaluation on intelligence and growth of children in endemic fluorosis and arsenism areas]. Chinese J Endemiology

IQ
lowered

NTP-1
NTP-3
2003 Agency for Toxic Substances and Disease Registry Toxicological Profile for Fluorides, Hydrogen Fluoride, and Fluorine U.S. Depart
Health and
Human
Services,
Public
Health
Service
Govt
report
TSCA-2
2003 Díaz-Cadórniga FJ, Delgado E, Tartón T, Valdés MM, Méndez A, Fernández MT, Rojo C. Endemic goiter associated with high iodine intake in primary school children in the  Saharawi  Arab Democratic Republic. Endocrinol
Nutr
Thyroid
Goiter
NTP-2
2003 Shao Q. Study of cognitive function impairment caused by chronic fluorosis. Chinese J
Endemiology
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2003 Xiang Q, Liang Y, Chen L, Wang C, Chen B, Chen X, Zhou M. Effect of fluoride in drinking water on children’s intelligence Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
NRC2006
2003 Xiang Q, Liang Y, Zhou M, Zang H. Blood lead of children in Wamiao-Xinhuai intelligence study (Letter). Fluoride More
research on
Xiang IQ
study cited
above.
NTP-3
TSCA-1
2001 Alarcon-Herrera MT, Martin-Dominguez IR, Trejo-Vazquez R, Rodriguez-Dozal S. Well water fluoride, dental fluorosis, bone fractures in the Guadiana Valley of Mexico. Fluoride Dose-
response
Bone
Dental-
fluorosis
TSCA-2
2001 Centers for Disease Control and Prevention Recommendations for using fluoride to prevent and control dental caries in the United States. MMWR Govt
report
TSCA-2
2001 Choubisa SL. Endemic fluorosis in southern Rajasthan, India. Fluoride *Classic fluorosis
Thyroid
NTP-2
2001

Wang X, Wang L, Hu P, Guo X, Luo X.

Note: NTP used the wrong authors in 2019. They used: Wang S, Wang L, Hu P, Guo S, Law S..

[Effects of high iodine and high fluorine on children’s intelligence and thyroid function]. Chinese J
Endemiology
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
2000 Fomon SJ, Ekstrand J, Ziegler EE. Fluoride intake and prevalence of dental fluorosis:  Trends in fluoride intake with special attention to infants. J Pub
Health
Dentistry
Infants TSCA-2
2000 Lu Y, Sun ZR, Wu LN, Wang X, Lu W, Liu SS.

Effect of high-fluoride water on intelligence in children.

Note: This is a duplicate of Liu et al (2008).

Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
NRC2006
1999 Fomon SJ, Ekstrand J. Fluoride intake by infants. J Pub
Health
Dentistry
Infants TSCA-2
1999 Jooste PL, Weight MJ, Kriek JA, Louw AJ. Endemic goitre in the absence of iodine deficiency in schoolchildren of the Northern Cape Province of South Africa. Eur J
Clin Nutr
Iodine
Goiter
NTP-2
TSCA-2
1998 Morgan L, Allred E, Tavares M, Bellinger D, Needleman H. Investigation of the possible associations between fluorosis, fluoride exposure, and childhood behavior problems. Pediatr
Dent
Behavior NTP-1
NTP-3
TSCA-2
1998 Zhang J, Yao H, Chen Y. [Effect of high level of fluoride and arsenic on children’s intelligence]. Chinese Journal
of Public Health
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
1997 Lamberg M, Hausen H, Vartiainen T. Symptoms experienced during periods of actual and supposed water fluoridation. Community
Dent
Oral
Epidemiol
Skin
rashes
NTP-1
1997 Yao Y, Deng Y, Yang S, Zhou J, Wang X, Cui Z. Comparative assessment of the physical and mental development of children in endemic fluorosis area with water improvement and without water improvement.

Lit and Info Preventive Medicine 

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
1996 Michael M, Barot VV, Chinoy NJ. Investigations of soft tissue functions in fluorotic individuals of North Gujarat. Fluoride Thyroid NTP-1
NTP-3
1996 Yao L, Zhou J, Wang S, Cui K, Lin F. Analysis of TSH levels and intelligence of children residing in high fluorosis areas.

Lit and Info Preventive Medicine 

Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
1996 Zhao LB, Liang GH, Zhang DN, Wu XR. Effect of a high-fluoride water supply on children’s intelligence. Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
NRC2006
1995 Balabolkin MI, Mikhailets ND, Lobovskaia RN, Chernousova NV. [The interrelationship of the thyroid and immune statuses of workers with long-term fluorine exposure]. Ter Arkh Thyroid NTP-2
1995 Duan J, Zhao M, Wang L, Fang D, Wang Y, Wang W. A comparative analysis of the results of multiple tests in patients with chronic industrial fluorosis. Guizhou
Medical
Journal
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
1995 Li  XS, Zhi  JL, Gao RO. 1995 Effect of fluoride exposure on the intelligence of children. Fluoride

IQ
lowered

NTP-1
NTP-3
TSCA-1
NRC2006
1995 Shimonovitz S, Patz D, Ever-Hadani P, Singer L, Zacut D, Kidroni G, Ron M. Umbilical cord fluoride serum levels may not reflect fetal fluoride status. J
Perinatal
Medicine
Mother-Offspring serum
levels
TSCA-2
1995 Watanabe M, Kono K, Orita Y, Dote T, Usuda K, Takahashi Y, Yoshida Y. Influence of dietary fluoride intake on urinary fluoride concentration and evaluation of corrected levels in spot urine. Fluoride Urinary
fluoride
NTP-3
1994 Brambilla E, Belluomo G, Malerba A, Buscaglia M, Strohmenger L. Oral administration of fluoride in pregnant women, and the relation between concentration in maternal plasma and in amniotic fluid. Archives
of Oral
Biology
F levels
in blood of pregnant women & levels in amniotic
fluid
TSCA-2
1994 Jacqmin H, Commenges D, Letenneur L, Barberger-Gateau P, Dartigues JF. Components of drinking water and risk of cognitive impairment in the elderly. Am J
Epidemiol
Cognitive impair-
ment
in elderly
NTP-1
NTP-3
1994 Xu Y, Lu C, Zhang X. Effect of fluoride on children’s intelligence. Endemic
Diseases
Bulletin 
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
1993 Centers for Disease Control and Prevention Fluoridation Census 1992 . Govt report Names of
cities &
towns
that
fluoridate
TSCA-2
1993 Desai VK, Solanki DM, Bansal RK. Epidemiological study of goitre in endemic fluorosis district of Gujarat. Fluoride Thyroid
Goiter
NTP-2
TSCA-2
1993 Dong Z, Wan C, Liu J. Determination of the contents of amino acid and monoamine neurotransmitters in fetal brains from a fluorosis endemic area. Journal
of Guiyang
Medical
College
Translated
by FAN
Fetal
brain
TSCA-1
1993 Gupta S, Seth AK, Gupta A, Gavane AG. Transplacental passage of fluoride. The Journal of Pediatrics Fetus TSCA-2
1992 An J, Mei S, Liu A, Fu Y, Wang C. [Effect of high level of fluoride on children’s intelligence] Chinese J
Control of
Endemic
Diseases 
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
1992 Chinoy NJ, Narayana MV. Studies on fluorosis in Mehsana District of North Gujarat.
Proceedings
Zoological
Society
of Calcutta
*Classic fluorosis NTP-1
NTP-3
1991 Lin F, Ai H, Zhao H, Lin J, Jhiang J, Maimaiti. 1991 High fluoride and low iodine environment and subclinical cretinism in Xinjiang. Endemic
Diseases
Bulletin
Repub
in
Iodine
Def
Disorder

IQ
lowered

NTP-1
NTP-3
TSCA-1
1991 Sun M, Li S, Wang Y, Li F. Measurement of intelligence by drawing test among the children in the endemic area of Al-F combined toxicosis. Journal  Guiyang
Medical
College 
Translated
by FAN

IQ
lowered

NTP-1
NTP-3
TSCA-1
1989 Tokar VI, Voroshnin VV, Sherbakov SV. [Chronic effects of fluorides on the pituitary-thyroid system in industrial workers]. Gig Tr
Prof
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Thyroid NTP-2
1987 Environmental Protection Agency Fluorine (Soluble Fluoride) (CASRN 7782-41-4).  Integrated Risk Information System. (last updated January 31, 1987). EPA Non-
cancer
assess-
ment
TSCA-2
1987 Hasling C, Nielsen HE, Melsen F, Mosekilde L. Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D. Miner
Electrolyte
Metab
Safety of treatment
with NaF
NTP-2
1986 Ron M, Singer L, Menczel J, Kidroni G. Fluoride concentration in amniotic fluid and fetal cord and maternal plasma. Eur. J.
Obstet.
Gynecol.
Reprod.
Biol.
Mother-Offspring
blood
levels
TSCA-2
1986 Shannon FT, Fergusson DM, Horwood LJ. Exposure to fluoridated public water supplies and child health and behaviour. New Zeal
Med J
Behaviour NTP-1
NTP-3
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1985 Bachinskii PP, Gutsalenko OA, Naryzhniuk ND, Sidora VD, Shliakhta AI. [Action of the body fluorine of healthy persons and thyroidopathy patients on the function of hypophyseal-thyroid the system]. Probl
Endokrinol
Thyroid NTP-2
1985 Yu YN. [Effects of chronic fluorosis on the thyroid gland]. Chin Med J Thyroid
No
Abstract
NTP-2
1984 US Department of Health and Human Services: 1-3.
Washington, DC
Fluoride in urine. In: Manual of Analytical Methods Vol 11. Method 8308. NIOSH
National
Institute for
Occupational
Safety
and Health)
 NTP-3
1983 Sidora VD, Shliakhta AI, Iugov VK, Kas’ianenko AS, Piatenko VG. [Indices of the pituitary-thyroid system in residents of cities with various fluorine concentrations in drinking water]. Probl
Endo-
krinol
Thyroid NTP-2
1982 Rotton J, Tikofsky RS, Feldman HT. Behavioral effects of chemicals in drinking water. J Appl
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Behavioral reactions NTP-1
NTP-3
1981 Baum K, Boerner W, Reiners C, Moll E. [Bone density and thyroid function in adolescents in relation to fluoride content of drinking water]. Fortschr
Med
Thyroid NTP-2
1981 Eichner R, Borner W, Henschler D, Kohler W, Moll E. [Osteoporosis therapy and thyroid function. Influence of 6 months of sodium fluoride treatment on thyroid function and bone density]. Fortschr
Med
Thyroid NTP-2
1980 Erickson JD. Down syndrome, water fluoridation, and maternal age. Teratology Downs syndrome NTP-1
1980 Still CN, Kelley P. The incidence of primary degenerative dementia vs. water fluoride content in South Carolina, USA. Neurotox Dementia
No
Abstract
NTP-1
NTP-3
1980 Tamboli BL, Mathur GM, Mathur AP, Lalla SK, Goyal OP. Prevalence of fluorosis in Pratabpura and Surajpura villages, District Ajmer (Rajasthan). Indian J
Med Res
*Classic fluorosis NTP-1
1976 Erickson JD, Hay S. Water fluoridation and congenital malformations: No association Journal of the American
Dental
Association
Downs Syndrome NTP-1
1976 Romer TEZ, Kowalczyk B, Kacprzak M, Wiktorowski M. [Incidence of goitre in pubertal girls of the Piotrkow Region and iodide content in drinking water]. Endokrynol
Pol
Goiter NTP-2
1974 Shen YW, Taves DR. Fluoride concentrations in the human placenta and maternal and cord blood. Am J
Obstetrics
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Gynecol
F levels
in
placenta
& blood
TSCA-2
1973 Grimm H. [The physical development of schoolchildren under the influence of drinking water fluoridation in Karl Marx Stadt]. Dtsch
Gesund-
heitsw
No
Abstract
NTP-2
1973 Sung FC, Chen KP, Chen CY, Tai PW, Yang CF. Studies of the effect of salt iodization on endemic goiter in Taiwan. IV. A survey of drinking water in relation to endemic goiter. J
Fomosan
Med
Assoc
Goiiter
Salt F
No
Abstract
NTP-2
1972 Day T, Powell-Jackson P. Fluoride, water hardness, and endemic goitre. Lancet Thyroid
Goiter
NTP-2
1969 Siddiqui AH. Incidence of simple goiter in areas of endemic fluorosis in Nalgonda District, Andhra Pradesh, India. Fluoride Thyroid
Goiter
NTP-2
1967 Latham MC, Grech P. The effects of excessive fluoride intake. Am J
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NTP-2
1964 Chuka A, Zhukovskil V, Mirku I, Postel’Niku D.
[Premature aging of the population in the zone of endemic goiter.] Vestnik
Akademii
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sinskikh
Nauk
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Thyroid
Goiter
 NTP-2
1964 Geeraerts F, Gijs G, Finné E, Crokaert R. Kenetics of fluoride penetration in liver and brain. Fluoride Blood-
Brain
Barrier
TSCA-2
1964 Leone NC, Leatherwood EC, Petrie IM, Lieberman L. Effect of fluoride on thyroid gland: Clinical study. Journal of the American
Dental
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1963 Berry WTC, Whittles JH. Absence of effect of fluoride upon the incidence of thyroid enlargements in Wiltshire schoolgirls. Mon Bull
Minist
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Health
Lab Serv
Thyroid NTP-2
1963 Gedalia I, Brand N. The relationship of fluoride and iodine in drinking water in the occurrence of goiter. Arch Int Pharma
codyn
Ther
Thyroid
Goiter
NTP-2
1962 Shtifanova AK. [The fluorine content in water, soil and vegetal products of the Alma-Atinsk District areas and its role in the etiology of dental caries and endemic goiter]. Zdravook-hranenie Kazakhstana Goiter
No
Abstract
NTP-2
1962 Singh A, Jolly SS, Devi P, Bansal BC, Singh SS. Endemic fluorosis: An epidemiological, biochemical and clinical study in the Bhatinda District of Panjab. Indian
J Med
Res
*Classic fluorosis NTP-1
1961 Feltman R, Kosel G. Prenatal and postnatal ingestion of fluorides: fourteen years of investigation — final report. J
Dental Medicine
Prenatal & postnatal ingestion
of F
TSCA-2
1961 Kolomiitseva MG. [The content of fluorine in the external environment of the Upper Altai autonomous region and its role in the etiology of endemic goiter]. Gig Sanit Goiter
No
Abstract
NTP-2
1961 Reisenauer R, Rezler D, Kremenová J, Preininger Q. [Fluorization of the waters in Czechoslovakia. IV. Endocrinological control of results of two years’ fluorization of drinking-water in school children]. Cesk Stomatol No
Abstract
NTP-2
1958 Gabovich RD, Verzhikovskaia NV. [Effect of fluoride compounds on absorption of radioactive iodine by the thyroid gland in humans and in experimental conditions]. Probl
Endo-
krinol Gormo-
noter
Thyroid
No
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NTP-2
1958 Galletti PM, Joyet G. Effect of fluorine on thyroidal iodine metabolism in hyperthyroidism. J Clin
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crinol
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1958 Hidehiko T. On the relation between the distribution of endemic goiter and the fluorine content of natural water in Hidaka Province, Hokkaido. Folia
Pharm
Jpn
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No
Abstract
NTP-2
1957 Galletti PM, Joyet G, Jallut O. [Effect of sodium fluoride on thyroid function in Basedow’s Disease]. Helv Med Acta Thyroid
No
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NTP-2
1956 Cherkinskii SN, Zaslavskaia RM. [Significance of fluorides in potable water in the development of endemic goiter]. Probl
Endo-
krinol Gormo-
noter
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No
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NTP-2
1956 Galletti P, Held HR, Korrodi H, Wegmann T. [Investigations on the possible damaging effect of fluorine on the thyroid gland]. Helv
Med
Acta
Thyroid NTP-2
1956 Jentzer A. [Effect of fluorine on the iodine content of the human thyroid gland]. Bull
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No
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NTP-2
1955 Korrodi H, Wegmann T, Galleti P, Held HR. [Caries prophylaxis and the untoward effects of fluor on the thyroid gland]. Schweiz Med Wochen-schr Thyroid
No
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NTP-2
1955 Levi JE, Silberstein HE. Lack of effect of fluorine ingestion on uptake of iodine 131 by the thyroid gland. J Lab
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No
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NTP-2
1954 Wespi HJ. [Iodized-fluoridized salt for the prevention of goiter and caries]. Schweiz Med Wochen-
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F salt
No
Abstract
NTP-2
1953 Hoffmann-Axthelm W. [Observations on the influence of fluorine on dental enamel and thyroid gland]. Dtsch Zahnarztl
Z
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No
Abstract
NTP-2
1950 Hodge HC. The concentration of fluorides in drinking water to give the point of minimum caries with maximum safety. J Am
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TSCA-2
1947 Fiorentini S, Galeazzi M, Visintin B.

Google Translation:

II fluorine in nature as a morbigenous agent II. Campagnano fluorosis in Rome. III. An outbreak of human fluorosis in Campagnano di Roma. IV. Radiological observations on the alveolar processes, on the maxillary bones, and on the appearance of the inhabitants of Campagnano. V. Fluorotic zone around Campagnano di Roma. V1. Frequency and clinical features of dental caries in fluorotic subjects.

Rend
Ist
Super-
iore
Sanita
Fluorosis
Bone
No
Abstract
NTP-2
1942 Dean HT. The investigation of physiological effects by the epidemiological method. In:
Fluorine
and
Dental
Health
,
Pub of
the Am Assoc
for
the
Advanc
of Sci,
No. 19 (Moulton, F.R.,
editor)
Physiology
No
Abstract
TSCA-2

*Classic Fluorosis: A crippling disease resulting from deposition of fluorides in the hard and soft tissues of body. Includes dental fluorosis, skeletal fluorosis, and non-skeletal fluorosis: Gastrointestinal symptoms, Neurological and Allergic manifestation, Harm to the Fetus (foetus), Low haemoglobin levels, and more.

Studies Translated by FAN (Fluoride Action Network) – see all translations

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