Fluoride Action Network

The National Toxicology Program

This section is dedicated to the National Toxicology Program’s (NTP) long involvement with the issue of fluoride's toxicity. The NTP is the scientific research arm for U.S. regulatory agencies. It comes under the aegis of the National Institute of Environmental Health Sciences (NIEHS). The NIEHS, in turn, comes under the umbrella of the National Institutes of Health (NIH).

NTP 2021: The 2nd NASEM Peer Review

Released February 9, 2021:

The second peer-review by the National Academies of Sciences, Engineering, and Medicine (NASEM) of NTP’s second draft is titled: Revised Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Letter Report.

NASEM also released a News Release concurrently with the release of its peer-review.

In its peer-review, the NASEM committee wrote:

… It is important to note that the committee did not conduct its own independent evaluation of the evidence, nor did it conduct a data audit; both were outside its scope.

… The monograph needs to emphasize that much of the evidence presented comes from studies that involve relatively high fluoride concentrations, and to make clear that the monograph cannot be used to draw conclusions about low fluoride exposure concentrations (less than 1.5 mg/mL), including those in fluoridated drinking water systems…

Chris Neurath, the Science Director of the Fluoride Action Network, presented a poster in 2020 titled, Fluoride Developmental Neurotoxicity: Dose-Response  Analyses of Recent High Quality Studies, at a conference of the International Society for Environmental Epidemiology (ISEE). Neurath noted:

Of the 29 human fluoride studies that the NTP classified as higher quality, 27 found neurotoxic effects.

Of those finding adverse effects: 18 were at fluoride levels below 1.5 mg/L and 13 at levels below 0.7 mg/L.

Neurath has demonstrated that with NTP’s own data, the high-quality studies finding loss of IQ at exposures below 1.5 mg/L are just as consistent and numerous as those above 1.5 mg/L.  Over 90% of the low-dose studies found loss of IQ.

See the NTP’s immediate reaction to NASEM’s peer review here

Documents and News Reports leading up to, and including, 2021

Date Agency Report
Sept 6, 2019 NTP The NTP’s first Draft NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.
http://fluoridealert.org/wp-content/uploads/2019.ntp_.draft-fluoride-systematic-review.online-Oct-22.pdf
March 5, 2020 NAS The NASEM’s first peer review of the Draft NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.
http://fluoridealert.org/wp-content/uploads/nas-review-of-ntp-review.march-5-2020.pdf
Sept 16, 2020 NTP The NTP’s revised (second) Draft Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.
http://fluoridealert.org/wp-content/uploads/ntp.revised-monograph.9-16-2020.pdf
2020-
2021
Neurath
– FAN
NEURATH: DOSE RESPONSE DOCUMENTS:
FAN dose-response assessment of Nov. 30, 2020
Appendix which provides the computer code used to generate the meta-analyses and meta-regressions
Data file in Excel format.xlsx”
Updated ISEE 2020 Conference poster
Supporting details for dose-response analysis summaries shown in ISEE 2020 Conference poster
and a
A zip file for:
Dose response analysis
Meta-analysis data high quality NTP studies
Feb 9, 2021 NAS The NASEM’s second peer-review of the revised (second) Draft NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Letter Report.
http://fluoridealert.org/wp-content/uploads/2021.nas-review-of-ntp-second-draft.feb-9.pdf
Feb 9 2021 NAS News Release from the National Academies of Sciences, Engineering and Medicine.
https://www.nationalacademies.org/news/2021/02/national-academies-complete-review-of-national-toxicology-programs-second-draft-monograph-on-fluoride-exposure-and-neurodevelopmental-and-cognitive-effects
Feb 11, 2021 ADA By Jennifer Garvin. National Academies ’strongly recommends’ third revision to fluoride monograph. ADA News (American Dental Association).
https://www.ada.org/en/publications/ada-news/2021-archive/february/national-academies-strongly-recommends-third-revision-to-fluoride-monograph
Feb 11, 2021 AFS Press Release. National Academies rejects the NTP draft report about fluoride. American Fluoridation Society.
https://www.prnewswire.com/news-releases/national-academies-rejects-the-ntp-draft-report-about-fluoride-301226659.html
Feb 16, 2021 FAN Press Release. According to Fluoride Action Network, the NAS strengthens findings on fluoride’s neurotoxicity. Fluoride Action Network.
https://www.prnewswire.com/news-releases/according-to-fluoride-action-network-the-nas-strengthens-findings-on-fluorides-neurotoxicity-301228676.html?tc=eml_cleartime

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