Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride Transport and Inhibition Across CLC Transporters.

August 31, 2022 | Handbook of Experimental Pharmacology | Asgharpour S, Chi LA, Spehr M, Carloni P, Alfonso-Prieto M. | pp 1-20. [Epub ahead of print]
Notes 1. Fluoride is isosteric with hydroxide and can compete with phosphate and carboxylate groups, thus acting as a substrate- or transition state-like inhibitor of several enzymatic reactions (Strunecka and Strunecky 2020). 2. Higher organisms can avoid fluoride’s harmful effects, thanks to the exquisite selectivity of most of their anion channels and transporters, which limits fluoride resorption in the gastrointestinal tract (Johnston and Strobel 2020). 3. Larger anions, su

[RETRACTED] Fluoride Exposure Suppresses Proliferation and Enhances Endoplasmic Reticulum Stress and Apoptosis Pathways in Hepatocytes by Downregulating Sirtuin-1.

August 21, 2022 | BioMed Research International | Yu Y, Li L, Yu W, Guan Z. | 2022:7380324.
1. Introduction Fluorine exists in the environment in the form of fluoride [1]. And fluorine is a vital trace element present in humans and animals, mainly in bones and teeth [2, 3]. While long-term exposure to fluoride in the air, food, and water can lead to fluorosis, it can also cause dental fluorosis and fluorosis bone disease [4]. It has also been confirmed that chronic fluorosis can result in extensive pathological damage to the body [5]. Excessive intake of fluorine will cause morphologi

The environmental impact of community caries prevention – part 3: water fluoridation.

August 26, 2022 | British Dental Journal | Duane B, Lyne A, Parle R, Ashley P. | 233:303–307
Authors and Affiliations Dental Public Health, Dublin Dental Hospital, Trinity College Dublin, D02 F859, Ireland Brett Duane Paediatric Dentistry, Eastman Dental Institute, Rockefeller, 21 University Street, London, WC1E 6DE, UK Alexandra Lyne & Paul Ashley Environmental Health Service National Water Operational Unit, Health Service Executive, Community Services Centre, Western Road, Clonmel, County Tipperary, E91 HT96, Ireland References UK Governm

Role of oxidative stress-mediated cell death and signaling pathways in experimental fluorosis.

August 17, 2022 | Chemico-Biological Interactions | Babu S, Manoharan S, Ottappilakkil H, Perumal E. | [Epub ahead of print]
Introduction Fluorine is one of the most reactive elements with high electronegativity and the second-highest electron affinity. It has an oxidation number of -1 and exists as either inorganic fluorides or organofluorine compounds [1,2]. F- exposure in humans occurs majorly from consuming water contaminated by F- from various natural and anthropogenic sources such as volcanic eruptions, mining residues, industrial effluents, phosphorus fertilizers, and certain domestic activities [3,4]. F