Abstract
Fluorine, a toxic and reactive element, is widely prevalent throughout the environment and can induce toxicity when absorbed into the body. This study was to explore the possible mechanisms of developmental neurotoxicity in rats treated with different levels of sodium fluoride (NaF). The rats’ intelligence, as well as changes in neuronal morphology, glucose absorption, and functional gene expression within the brain were determined using the Morris water maze test, transmission electron microscopy, small-animal magnetic resonance imaging and Positron emission tomography and computed tomography, and Western blotting techniques. We found that NaF treatment-impaired learning and memory in these rats. Furthermore, NaF caused neuronal degeneration, decreased brain glucose utilization, decreased the protein expression of glucose transporter 1 and glial fibrillary acidic protein, and increased levels of brain-derived neurotrophic factor in the rat brains. The developmental neurotoxicity of fluoride may be closely associated with low glucose utilization and neurodegenerative changes.
-
-
Changes of learning and memory ability and brain nicotinic receptors of rat offspring with coal burning fluorosis.
The purpose of the investigation is to reveal the mechanism of the decreased ability of learning and memory induced by coal burning fluorosis. Ten offspring SD rats aged 30days, who were born from the mothers with chronic coal burning fluorosis, and ten offspring with same age from the normal mothers
-
Effects of fluoride on learning and memory and cholinesterase activity in rat brains.
Objective: To study the role of fluorosis on learning and memory in rat and its possible mechanisms; to explore the correlation between cholinesterase activity and the level of intelligence. Methods: SD rats divides into 3 group of stochastically according to the sex and the body weight, control group treated with
-
Behavioral teratology in rats exposed to fluoride.
A study was conducted of behavioral differences in Wistar rat pups born of dams drinking water containing 1.0, 5.0, and 25 mg F/L from the day of conception. A control group drank tap water containing 0.6 mg F/L. Among 18 litters in the 25 mg/L group, four of the dams
-
Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels.
Previous studies suggest that sodium fluoride (NaF) can impair performance in some memory tasks, such as open-field habituation and two-way active avoidance. In the present study, we evaluated the effect of NaF intake (100 ppm in drinking water for 30 days) and its short-term (15 days) withdrawal on open-field habituation and brain monoamine
-
Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice.
SUMMARY: Learning-memory behavior was tested in mice on a Y-maze after they drank water containing different concentrations of sodium fluoride. Impairment of the structure of the Gray I synaptic interface in the CA3 area of the hippocampus was analyzed quantitatively by electron microscopy and a computer imaging processor. The main
Related Studies :
-
-
-
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
-
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
-
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
-
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
-
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
Related FAN Content :
-