Abstract
Objective: To study the effects after six months of exposure of mice to increasing concentrations of fluoride in drinking water (tap water, 10, 50, and 100 mg F/L) on their cerebral functions.
Methods: Learning and memory abilities of high-fluoride exposed and control groups of mice were measured by a behavior-toxicological test (Shuttle-box Test), and the cholinesterase (ChE) activity in brain tissue homogenates of the mice was determined.
Results: Learning and memory abilities of the fluoride-exposed groups were significantly lower than those of the control group, and the brain ChE activities of the fluoride-exposed groups were significantly higher.
Conclusions: Elevated fluoride concentration in drinking water can decrease the cerebral functions of mice. Fluoride is a neurotoxicant.
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Acetylcholinesterase activity in fluorosis adversely affects mental well-being: an experimental study in rural Rajasthan
Fluoride toxicity is a burgeoning problem worldwide and also in Rajasthan in India. In the state of Rajasthan, almost all districts have high fluoride (up to 18.0 ppm) in their drinking/ground water sources and about 11 million of the population [is] at risk. Several clinical and experimental studies have reported
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Effects of fluoride on learning and memory and cholinesterase activity in rat brains.
Objective: To study the role of fluorosis on learning and memory in rat and its possible mechanisms; to explore the correlation between cholinesterase activity and the level of intelligence. Methods: SD rats divides into 3 group of stochastically according to the sex and the body weight, control group treated with
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Changes in learning and memory ability and brain cholinesterase activity in the rats with coal burning fluorosis.
Objective: To observe the influence of coal burning fluorosis on learning and memory ability in rats and reveal its possible mechanisms. Methods: Healthy 48 SD rats were divided into control, low-fluoride and high-fluoride group. All rats in fluoride exposed groups were fed with the eom polluted by drying processes with
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Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats
Nine-six Wistar rats were randomly divided into four groups of 24 rats in each group (female:male = 1:1). Over a period up to 90 days, with one untreated group as controls, the other three groups were administered, respectively, high fluoride (100 mg NaF/L), high arsenic (50 mg As2O3/L), or both
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[Effects of high fluoride and low Iodine on learning-memory and TchE of brain in offspring rats].
Objective To study the effect of high level fluoride and low level iodine on learning-memory in offspring rats and possible mechanism. Methods Thirty-two Wistar rats were randomly divided into four groups each of eight (female:male=(3:1).) The rats were treated with high fluoride (100 and 150 mg NaF/L), low iodine (0.0855 mg/kg),
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