Abstract
The present study was carried out to study the effect of acute doses of sodium fluoride on the collagen content of the rat kidneys. Five groups of rats were studied: (i) control rats and (ii) rats divided into four subgroups according to the dose of NaF. Results showed that higher doses of sodium fluoride 10, 20 and 30 mg of NaF/kg body weight caused a significant decrease in the collagen content of the kidneys when compared to the control rats. Electron microscope studies supported these results and showed the sodium fluoride doses 10, 20 and 30 mg of NaF/kg body weight caused disruption of ordered collagen fibrils of the rat kidneys.
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Deterioration of renal function in ICR-derived glomerulonephritis (ICGN) mice by subacute administration of fluoride in drinking water.
Sodium fluoride was administered at 0, 25, 50, 100, and 150 ppm F in drinking water for 4 weeks to Institute of Cancer Research (ICR) derived glomerulonephritis (ICGN) mice. Fluoride was also administered to ICR mice at 0 and 150 ppm. Blood was sampled from the tail artery of each
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Chronic kidney diseases of uncertain etiology (CKDue) in Sri Lanka: geographic distribution and environmental implications
The increase in the number of chronic kidney disease (CKD) patients from the north central region of Sri Lanka has become a environmental health issue of national concern. Unlike in other countries where long-standing diabetes and hypertension are the leading causes of renal diseases, the majority of CKD patients from
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Induction of oxidative stress on reproductive and metabolic organs in sodium fluoride-treated male albino rats: protective effect of testosterone and vitamin E coadministration
The present study was undertaken to search out the effect of sodium fluoride, a water pollutant noted throughout the world, including India, on oxidative stress induction in reproductive tissues, sperm pellet, and metabolic tissues like the liver and kidney. The protective effects of testosterone or vitamin-E coadministration were also observed
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Free radical-induced nephrotoxicity following repeated oral exposure to chlorpyrifos alone and in conjunction with fluoride in rats
BACKGROUND/AIM: Chronic renal disorder is becoming a major health problem worldwide. The purpose of the present study was to investigate alterations in the renal antioxidant system in rats induced by repeated exposure to chlorpyrifos (CPF) alone and in conjunction with fluoride. MATERIALS AND METHODS: Wistar rats were randomly allocated to seven
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Studies on effects of fluoride in 36 villages of Mehsana District, North Gujurat"
A survey was carried out in 36 fluoride endemic villages of Mehsana District of North Gujarat. Urine and blood samples of fluoride-afflicted human population and their drinking water were analysed for fluoride content and compared with samples from different parts of Ahmedabad city (control). The fluoride content in water samples
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Fluoride Gels & Kidney Function
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Fluoride as a Cause of Kidney Disease in Humans
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Fluoride as a Cause of Kidney Disease in Animals
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Kidney: A potential target for fluoride toxicity
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