Abstract
Based on evidence that fluoride ion (F) increases the production of reactive oxygen species, inhibits antioxidant enzyme activity, and enhances lipid peroxidation, a study of these effects was conducted on 52 patients with chronic renal failure (CRF), of whom 33 were under going chronic haemodialysis (HD) with the use of polysulphone membrane dialysers, while 19 with less advanced CRF, who were not undergoing HD, were treated conservatively with angiotensin-converting enzyme inhibitors and diuretics. Serum concentrations of F, Cu, Zn, Se, and thiobarbituric acid reactive substances (TBARS), along with serum activity levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx), were measured. Although serum F levels were higher both before (p<0.001) and after (p<0.002) HD than in the conservatively treated group, HD resulted in a statistically significant (p<0.005) decrease of the F level. In both patient groups, a positive correlation was found between the levels of serum F and TBARS. In patients undergoing HD, a negative correlation was observed between the serum F level before HD and SOD activity (p<0.01) on the one hand and copper levels (p<0.0004) on the other. In the conservatively treated patients not undergoing HD, the GPx activity level in the serum was positively correlated with the F level. Thus an oxidation promoting action of F in patients with CRF was confirmed
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High fluoride exposure in hemodialysis patients
The observation of higher plasma flouride levels in our hemodialysis (HD) patients than our continuous ambulatory peritoneal dialysis (CAPD) patients (4.0 +/- 0.5 mumol/L [n = 17] v 2.5 +/- 0.3 mumol/L [n = 17], P less than 0.005) prompted an evaluation of fluoride metabolism during HD. We found that
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Association between fluoride, magnesium, aluminum and bone quality in renal osteodystrophy
INTRODUCTION: Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number of studies have linked
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Inorganic fluoride kinetics and renal tubular function after sevoflurane anesthesia in chronic renal failure patients receiving hemodialysis
Although sevoflurane is used in clinical anesthesia, its effects on renal function and inorganic fluoride (F-) kinetics in patients with chronic renal failure (CRF) have not been determined. We investigated F- kinetics and renal tubular function in sevoflurane anesthesia in CRF patients having hemodialysis. Five patients dialyzed and five with
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Bone fluoride in patients with uremia maintained by chronic hemodialysis
Bone specimens from 42 patients with end-stage renal disease and from 9 patients without renal or bone disease have been analyzed for the content of fluoride, calcium, and phosphorus. Thirty-one patients were treated with chronic hemodialysis for periods ranging up to 56 months by employing dialysate made up with tap
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Comparison of renal osteodystrophy in patients dialyzed with deionized and non-deionized water
Discussion There are 2 major types of osteodystrophy which occur in various combinations in dialysis patients. The first and most commonly predominant is secondary hyperparathyroidism. This appears to be preventable, or at least controllable, with a bath calcium concentration above 6 mg%. The second type is osteomalacia. In certain centers it
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Fluoride & Osteomalacia
One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid content of bone. Osteoid is unmineralized bone tissue. When bones have too much of it, they become soft and prone to fracture -- a condition known as osteomalacia. As shown below, fluoride has repeatedly been
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Fluoridation, Dialysis & Osteomalacia
In the 1960s and 1970s, doctors discovered that patients receiving kidney dialysis were accumulating very high levels of fluoride in their bones and blood, and that this exposure was associated with severe forms of osteomalacia, a bone-softening disease that leads to weak bones and often excruciating bone pain. Based on
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Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients
Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,
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Dental Fluorosis & Enamel Hypoplasia in Children with Kidney Disease
Children with kidney disease are known to have high levels of fluoride in their blood and to be at risk for disfiguring tooth defects. Research suggests that high levels of fluoride in blood, which can cause the tooth defect known as dental fluorosis, can contribute to the defects that occur
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Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.
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